Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'When exposed to stress, mRNAs released after translational arrest condense with RNA binding proteins, resulting in the formation of membraneless RNA protein (RNP) condensates known as processing bodies (P-bodies) and stress granules (SGs). However, the impact of the assembly of these condensates on the biophysical properties of the crowded cytoplasmic environment remains unclear.'
#preprint

https://www.biorxiv.org/content/10.1101/2023.05.30.542963v2

'At a public-safety hearing on Long Island in May 2011, while teams of rescue workers and police officers were still searching the bramble of Gilgo Beach, Dominick Varrone, the chief of detectives of the Suffolk County Police Department, suggested that the public could be at ease because the killer was selecting only a certain sort of victim. The subtext was clear: If the victims had been successful and well-educated, like the victims of David Berkowitz, the serial killer known as Son of Sam, all of Long Island might need to be in a panic. But everyone could relax. Sex workers didn’t seem to deserve the same consideration.'

https://www.nytimes.com/2023/07/15/nyregion/gilgo-beach-serial-killer-rex-heuermann.html?smid=nytcore-ios-share&referringSource=articleShare

'With the financial backing of medical device manufacturers, he has become a leader of a booming cottage industry that peddles risky procedures to millions of Americans — enriching doctors and device companies and sometimes costing patients their limbs.'

https://www.nytimes.com/2023/07/15/health/atherectomy-peripheral-artery-disease.html

"The Blues is personal catastrophe lyrically expressed."
- Cornel West

https://aeon.co/videos/cornel-west-navigates-the-messy-business-of-meaning-making-on-a-whirlwind-drive

'In this Review, we present current knowledge on the role of MDSCs in the immunotherapy of melanoma. We describe the accumulation, infiltration, and immunosuppressive functions of MDSCs in the tumor microenvironment (TME) as well as existing therapeutic strategies to target them in melanoma-bearing hosts. A special focus is placed on preclinical studies and clinical trials applying MDSC inhibition to overcome resistance to ICIs.'

#immunology #immunotherapy #immunooncology

https://www.jci.org/articles/view/170762

'She also points out that some viruses such as Ebola and Zika don’t have a known latent phase, yet “we know people where, six months after recovery, you get transmission of #Zika, or #Ebola, or reactivation of problems . . . That means that full length RNA is there and can resume production.”
#Virology

https://www.bmj.com/content/382/bmj.p1156

'Using a high throughput compatible assay that measures real-time translocation of the glucose transporter glucose transporter 4 (GLUT4), we identified small molecules that potentiate insulin action. In vivo, these insulin sensitizers improve insulin-stimulated GLUT4 translocation, glucose tolerance, and glucose uptake in a model of IR'

#metabolism #insulin

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00190-3