Thiago Carvalho @cyrilpedia@social.cleverlibre.org

STING is a channel?

'On the basis of structural analysis, we hypothesized that human STING is a proton channel. Indeed, we found that STING activation induced a pH increase in the Golgi and that STING reconstituted in liposomes enabled transmembrane proton transport.'

https://www.science.org/doi/10.1126/science.adf8974

'I was a cub reporter, with limited insight, for the public broadcaster.Following HIV during a controversial time when the government refused to provide antiretroviral drugs to people infected with the virus, quickly taught me an important thing – a pandemic isn’t simply a disease gone viral. It’s a political, social, economic and human rights crisis, because the germ that causes the outbreak travels through a society ravaged by inequality.'
#PublicHealth #Pandemic

https://www.theguardian.com/global-development/commentisfree/2023/aug/07/a-pandemic-is-not-just-a-disease-its-a-political-social-and-economic-crisis-fuelled-by-inequality

It's summer in Portugal, so we are required by law to grill sardines.

The 988 hotline is for anybody experiencing distress, anywhere in the United States.

You can call for yourself, for someone in your family or a friend. It’s available 24/7, and it’s free and confidential.

#health #mentalhealth #stress #PSA
https://theconversation.com/as-suicides-rise-in-the-us-the-988-hotline-offers-hope-but-most-americans-arent-aware-of-it-210356

People are getting paid for #publishing #AI-written #books, in an #author's name, when in fact the author did not, and knew nothing about this happening.

Then, when the author tries to do something about it to stop this obvious #abuse, they are told no.

Paul Dirac (1902, discovered the relativistic equation for the wave function of fermions), Ernest Lawrence (1901, invented the cyclotron), and Roger Penrose (1931, developed the global view of spacetime and much of what we know about singularities in GR) were all born #OTD. Pretty good day for physics.

“If they don’t give you a seat at the table, bring a folding chair.”

—Shirley Chisholm

#Montgomery #montgomerybrawl #BlackMastodon #Mastodon

Early disease-outbreak warnings matter. So why is the major alert system ProMED being hollowed out? https://www.theglobeandmail.com/opinion/article-early-disease-outbreak-warnings-matter-so-why-is-a-major-alert-system/?utm_medium=Referrer:+Social+Network+/+Media&utm_campaign=Shared+Web+Article+Links

Once again Ted Chiang has it exactly right. The immediate danger from #AI is not that it will become sentient and do whatever it wants. The danger is that it will do exactly what it’s being designed to do: help rich corporations destroy the working class in pursuit of ever-greater profits and thus concentrate wealth in fewer and fewer hands.

https://www.newyorker.com/science/annals-of-artificial-intelligence/will-ai-become-the-new-mckinsey

We keep updating this collection of heat records that were broken this summer with new heat records that were broken this summer https://scientificamerican.com/article/here-are-the-stunning-heat-records-set-so-far-this-summer1/

I made the terrible mistake of dimly remembering that the Portuguese man-o-war is not a jellyfish so trying to find out what they actually *are*

Anyway turns out they are floating colonies of at least 4 specialised organisms and science doesn't actually know anything about the early stages of their development, and there's at least one bit on the sex module (which they have, and it fucking swims off) that science no idea what it does.

#Florida schools get OK for climate-denial videos. https://www.eenews.net/articles/in-desantis-fla-schools-get-ok-for-climate-denial-videos/

New article! Read Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery https://www.nature.com/articles/s41541-023-00707-w?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines

Be prepared with numbers & facts to tell the story of your library's usage patterns. We've developed resources to help libraries in better leveraging data in negotiations with publishers.

https://sparcopen.org/our-work/negotiation-resources/data-analysis/ )"

@cyrilpedia in my lab we have so much single-use plastic equipment… and all the packaging…. If not contaminated it’s supposedly recycled but still, it makes me really sad. At least we have reusable gowns- in another lab I was they were also single use! 😱

A guide to where the world is on AI regulation, focusing on the different approaches in EU/US/China, from Matt Hutson.
The EU: regulate by risk; the US: ‘the appearance of activity’; China: keeping societal control.
https://www.nature.com/articles/d41586-023-02491-y