Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'As a child, I was taken to see an animated film version of George Orwell’s novel “Animal Farm.” Much too young to understand that I was watching an allegory about Stalinism, I assumed that Orwell was a sort of downbeat Disney, making scary kids’ cartoons featuring brutal, dictatorial pigs and overworked horses sent to slaughter.'

https://www.washingtonpost.com/books/2023/08/16/orwell-animal-farm-wife-biography/

'Prof Danny Altmann, an immunologist at Imperial College London, said: “JCVI have done their calculation in favour of a very limited vaccine offer for the elderly and immunosuppressed, leaving the bulk of the population way out from their last dose and poorly protected.”

https://www.theguardian.com/world/2023/aug/17/covid-vaccines-should-be-available-privately-uk-scientists-say?CMP=Share_iOSApp_Other

"But when Damon is asked if he would have approved Oppenheimer’s clearance again in 1954, he said no, but that he also wouldn’t approve clearances for any of the other scientists on the project. He had figured out from hanging around with these characters for three years that scientists couldn’t keep scientific findings to themselves."
@holden

https://holdenthorp.substack.com/p/oppenheimer-shows-scientists-humanity?r=nm6fe&utm_medium=ios&utm_campaign=post

First in human trials of a CART cell using a llama single domain ab construct targeting mesothelin in solid tumors.

#Immunology #Immunotherapy

https://www.nature.com/articles/s41591-023-02452-y

"Ventura divulgou factos falsos com o conhecimento de o serem e fê-lo de forma deliberada e apta a enganar as pessoas e - desta vez - com a agravante de ter feito passar os conteúdos que divulgou por notícias da Renascença e do PÚBLICO. E a divulgação que fez foi massiva. Isto merece tutela penal."

https://www.publico.pt/2023/08/16/opiniao/opiniao/andre-ventura-politico-mentiroso-2060310

"(...) the sole surviving manuscript of the Ethics was deposited in the archives of the Roman Inquisition by Steno, who also submitted an indictment of his former friend to the Inquisitors. They did their work well: their subsequent investigation provides one of the main sources for Spinoza’s life. "

https://thecritic.co.uk/issues/august-september-2023/a-brilliant-biography-of-an-elusive-genius/

The preclinical work on CD47, which binds SIRPα to deliver a 'don't eat me signal', was very compelling. But as a druggable target it's had a bumpy ride in clinical development.

'Pfizer executives were bullish during a second quarter earnings call Thursday that its two CD47 meds would not face the same setbacks seen from rivals Gilead and others. As a result, the New York pharma is staying the course.'
(HT Michael Tomasson)
#Immunology #immunotherapy #InnateImmunity

https://www.fiercebiotech.com/biotech/pfizer-undeterred-cd47-plans-competitors-face-pitfalls

We are delighted to welcome Renata Basto, Kairbaan Hodivala-Dilke and Megan King as new Editors at Journal of Cell Science.

Read more in the Editorial from our Editor-in-Chief Michael Way, including the importance of journal reputation: https://journals.biologists.com/jcs/article/136/16/jcs261519/325896/Say-hello-wave-goodbye

Thanks to Maria Carmo-Fonseca, David Glover and Arnoud Sonnenberg, who are stepping down as Editors, for their many years of service for the journal.

Health care CEOs hauled in $4 billion last year as inflation pinched workers

https://www.statnews.com/2023/08/17/health-ceo-salaries-compensation/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic

Hi #ScienceMastodon, I'm happy to share with you the last Research Highlight from JCS Issue 15. Paul Gleeson and colleagues from the University of Melbourne and Rheinische Friedrich-Wilhelms-Universität Bonn use blood outgrowth endothelial cells to map out the intracellular trafficking route of human serum albumin.
#CellBiology #vascularbiology #endocytosis

A rapid recycling route rescues HSA from degradation

https://journals.biologists.com/jcs/article/136/15/e136_e1504/325864/A-rapid-recycling-route-rescues-HSA-from

Feeling like a newborn here, trying to locate fellow scientists interested in #octopus #killifish #developmentalBiology #evodevo #neuroscience #sciencefunding

Two brands suspending advertising on X (#Twitter) after their ads appeared next to pro-Nazi content. https://www.cnn.com/2023/08/16/tech/x-ads-pro-nazi-account-brand-safety/index.html

#SanFrancisco, #Calif. Apr. 1942. Early comers, part of the #first contingent of 664 residents of #Japanese ancestry to be evacuated from #SanFrancisco, who will later be housed in #War relocation authority centers for the duration of the war

https://www.loc.gov/pictures/item/2001705945/

“..CNS symptoms occur between 0 days and 4 weeks after SARS-CoV-2 infection.” Most common CNS symptoms: Memory deficits, unresponsiveness, mental and behavioural disorders. “Seven of 12 cases can be categorized as probable SARS-CoV-2 encephalitis, and 5 cases can be described as brainstem encephalitis, acute disseminated encephalomyelitis, optic neuritis, multiple sclerosis or tremor probably associated with SARS-CoV-2 infection” https://link.springer.com/article/10.1007/s00415-023-11912-x

'Una nueva investigación, llevada a cabo por expertos del Memorial Sloan Kettering Cancer Center de Nueva York y de la Universidad de Zurich ha encontrado un obstáculo añadido a esta difícil ecuación: “el sobreprecio” o “la prima” del cáncer (”the cancer premium”, en inglés).“'

https://elpais.com/sociedad/2023-08-16/la-prima-del-cancer-por-que-los-tratamientos-oncologicos-cuestan-hasta-el-triple-que-los-demas-medicamentos.html