Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Online Now: Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00690-1?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Just a note that AlphaMissense is not the "Alphafold for point mutants" that some seem to be saying it is.

"Notably, AlphaMissense does not predict the structural changes of the mutated amino acid sequences but instead predicts pathogenicity as scalar values."
#StructuralBiology @strucbio

Accurate proteome-wide missense variant effect prediction with AlphaMissense | Science https://www.science.org/doi/10.1126/science.adg7492

@proteomicsnews blog post | It's September 21st! There is a mass spec symposium all day in Rockville today! | https://proteomicsnews.blogspot.com/2023/09/its-september-21st-there-is-mass-spec.html #proteomics

'Son los retrovirus endógenos humanos (HERV, por sus siglas en inglés), reliquias virales sin capacidad infectiva que se quedaron en el organismo tras infecciones que sufrieron nuestros ancestros hace millones de años.'

https://elpais.com/salud-y-bienestar/2023-09-20/el-misterioso-rol-de-los-virus-ancestrales-incrustados-en-el-adn-humano.html

'Some selection-based theories propose that genome streamlining, favoring smaller genome sizes, is advantageous in nutritionally limited environments, particularly under P-limitation. To test this prediction, we conducted several experimental evolution trials on clonal populations of a facultatively asexual rotifer that exhibits intraspecific variation in genome size.'

https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad144/7277129?searchresult=1

"The moment you and your story are overwhelmed by the furious storm of the times - that's when the real novel begins."
Walter Mosley, Elements of Fiction.

#books #bookshelf #writing #bookstodon

@yoginho
Really great! I'm also reminded of this article:

Philosophical Plumbing,
by Mary Midgley

Plumbing and philosophy are both activities that arise because elaborate cultures like ours have, beneath their surface, a fairly complex system which is usually unnoticed, but which sometimes goes wrong. In both cases, this can have serious consequences.

Each system supplies vital needs for those who live above it. Each is hard to repair when it does go wrong, because neither of them was ever consciously planned as a whole. There have been many ambitious attempts to reshape both of them, but existing complications are usually too widespread to allow a completely new start ...

When trouble arises, specialized skill is needed if there is to be any hope of locating it and putting it right. Here, however, we run into the first striking difference between the two cases. About plumbing, everybody accepts this need for specialists with painfully acquired technical knowledge. About philosophy, people—especially British people—not only doubt the need, they are often sceptical about whether the underlying system even exists at all ...

H/T to @awaisaftab for the pointer

https://www.cambridge.org/core/journals/royal-institute-of-philosophy-supplements/article/philosophical-plumbing/A852BF55F9DF8506898FB51C6E4E41B1

Germany's Merck puts $1.3bn into AI drug development through new deals with Exscientia and BenevolentAI

https://pharmaphorum.com/news/merck-puts-13bn-ai-exscientia-benevolentai-deals

#pharma #pharmaindustry #AI #artificialintelligence #exscientia #benevolentAI #merck #MerckKGaA

India to mandate annual audit of pharma suppliers by drugmakers

https://economictimes.indiatimes.com/industry/healthcare/biotech/pharmaceuticals/india-to-mandate-annual-audit-of-pharma-suppliers-by-drugmakers/articleshow/103815356.cms

#pharma #pharmaindustry #india

#Introduction
I was never on twitter, but I figured I'd try out Mastodon. I'm a chemist and chemical biologist by training and my work comes home a bit too often as an amateur baker. I've done bike commuting in worse climates with better infrastructure (Fort Collins, CO and PDX) and better climates with much worse infrastructure (Orange County, CA). Anti-car, pro-community.
#Science #Chemistry #ChemicalBiology #Baking #Biking #BikeCommuting

'A single intramuscular injection of Lenti-HPV-07 into mice bearing established HPV-induced tumors resulted in complete tumor eradication in 100% of the animals and was also effective against lung metastases.'
#TumorImmunology #Immunology #immunotherapy
Douguet et al @EmboMolMed

https://www.embopress.org/doi/full/10.15252/emmm.202317723

'I was disturbed to learn how much worse McKinsey’s contributions became after I left. Reporting from ProPublica and The New York Times found that the firm helped increase arrests and speed up deportations. Some of its advice was so extreme that it made even ICE staff uncomfortable.'

https://www.thenation.com/article/society/mckinsey-whistleblower-confessions/?ref=thebrowser.com

Factoid du jour:

"Significantly higher oxygen affinity of fetal blood is found almost universally among mammals. The only exception that has been noted to date is the domestic cat."

https://www.sciencedirect.com/science/article/pii/S0006497120630075#bib38