Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
“It became the custom in such cases to give credit solely to the one who actually made the experiment work, even if others may have also conceived the idea. It was the drosophilists’ golden rule. Ideas that were engendered in the group’s informal shoptalk were treated as communal resource and not as personal property.”
(Robert E. Kohler, Lords of the Fly)
#Books #Bookshelf #ScienceHistory #SciComm #Drosophila #bookstodon
Thiago Carvalho
boosted
Talmo Pereira (https://talmolab.org/research/) will present a #webinar on "Quantifying #behavior using #DeepLearning"
⏰ October 16, 2023, 16:00 CET
🌍 https://helsinki.zoom.us/meeting/register/u5clcu2qqTstHNyfk9lcMSijYZIS7hXpaNc4#/registration
Thiago Carvalho
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'Here, 273 individuals with or without LC were enrolled in a cross-sectional study that included multi-dimensional immune phenotyping and unbiased machine learning methods to identify biological features associated with LC.'
Thiago Carvalho
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'Un estudio publicado recientemente en la revista BMJ Oncology calcula que la incidencia mundial de tumores entre menores de 50 años ha aumentado un 79% en tres décadas. '
Thiago Carvalho
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"The insecticides used since the 1970s, to spray in houses and on bed nets to protect sleeping children, have become far less effective; mosquitoes have evolved to survive them. After declining to a historic low in 2015, malaria cases and deaths are rising."
https://www.nytimes.com/2023/09/29/health/mosquitoes-malaria-disease-climate-change.html
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
Merck filed a biologics license application for sotatercept in pulmonary arterial hypertension & now the FDA has granted it priority review.
https://www.merck.com/news/merck-receives-priority-review-from-fda-for-new-biologics-license-application-for-sotatercept-an-activin-signaling-inhibitor-to-treat-adults-with-pulmonary-arterial-hypertension-pah/
I wrote about the drug last fall for Nature Medicine:
"BMPR-II regulates apoptosis and has anti-proliferative effects on pulmonary smooth muscle and endothelial cells. Sotatercept should assist BMPR-II in its tug-of-war with another TGF-beta family member, ActRIIA (which promotes proliferation), by selectively trapping activin pathway ligands. Unlike existing therapies that provide symptomatic management, sotatercept has the potential to be a curative treatment for pulmonary arterial hypertension by modifying the underlying causes of the disease."
Tools
"Natural proteins are composed of 20 proteinogenic amino acids and their post-translational modifications (PTMs). However, due to the lack of a suitable nanopore sensor that can simultaneously discriminate between all 20 amino acids and their PTMs, direct sequencing of protein with nanopores has not yet been realized."
Thiago Carvalho
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The first sentence of Paul Theroux's "The Pillars of Hercules" is still one of my favorites
Thiago Carvalho
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1st of Oct 1990, 33 yrs ago, I stepped into the Genetics Dept to work with Michael Ashburner. Those in the know will realise that the real celebration will be in ~122 days 😎😎
Thiago Carvalho
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There is ‘no limit’, write Nesse and Williams, ‘to the precision and complexity of adaptation that the Darwinian process can generate’.
All hail natural selection!
… unless, of course, the needed mutations fail to occur. #evolution
Thiago Carvalho
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Norway wants Facebook behavioural advertising banned across Europe.
Norway has told the European Data Protection Board (EDPB) it believes a countrywide ban on Meta harvesting user data to serve up advertising on Facebook and Instagram should be made permanent and extended across Europe.
https://www.theregister.com/2023/09/29/norway_facebook_behavioral_ads/
#Europe #Norway #EU #EuropeanDataProtectionBoard #EDPB #Facebook #Meta #Advertising #Privacy
Thiago Carvalho
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I've started a substack! I'll be using it instead of Twitter threads to post about latest Covid situation, latest NHS stats etc.. easier to share here on Mastadon, but more importantly, ensures my content remains *free*!
Next week, I'll be posting about latest Covid situation but also a look back at all the data we *used* to have and common biases in Covid data !
If you've valued what I've been doing on social media, please do subscribe - it's free!
open.substack.com/pub/christin... 1/2
Thiago Carvalho
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'However journal-level metrics fail to identify up to 90% of the equally well-cited papers in the biomedical research literature, controlling for field and year of publication (4). In other words, the recall of the biomedical community’s chosen measure of meritorious papers is on the order of a dismal 10%'
Thiago Carvalho
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Laboratory Manager
Solgate GmbH
We are seeking to #recruit a Laboratory Manager. A unique opportunity awaits you at our Biotech Startup! Apply to join our international team #JoinUs
See the full job description on jobRxiv: https://jobrxiv.org/job/solgate-gmbh-27778-laboratory-manager/?feed_id=60278
#ScienceJobs #hiring #research
Klosterneuburg #Austria #ResearchTechnician
https://jobrxiv.org/job/solgate-gmbh-27778-laboratory-manager/?feed_id=60278
"Elon Musk, the billionaire CEO of Tesla and SpaceX, attacked Germany's center-left governing coalition for supporting migrants on Friday and boosted a call for the German people to support a far-right extremist party instead."
Thiago Carvalho
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Dose-finding study of rituximab, lenalidomide, and ibrutinib (R2I) in relapsed/refractory mantle cell #lymphoma
Gives hope, but be aware there are many issues (too numerous to mention in a toot) with small single-arm studies, such as how many were relapsed versus refractory, and Quality of Life while on continuous treatment. Let's hope the study team confirms with a larger controlled study.
#MEDMASTODON #lymphoma #Cancer #fedscience
#ClinicalResearch #Oncology #Medicine #lymsm @majorajay
Thiago Carvalho
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Wow! Who knew?
If medical staff upgrade their masks they can eliminate ward-based #covid infections in hospital? s/
#maskup
https://www.theguardian.com/world/2021/jun/29/cambridge-hospitals-mask-upgrade-appears-to-eliminate-covid-19-risk-to-staff
Thiago Carvalho
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"I died as a mineral and became a plant,
I died as plant and rose to animal,
I died as animal and I was Man.
Why should I fear? When was I less by dying?"
The Mystics of Islam (1914) edited by Reynold Alleyne Nicholson
Rūmī was born #OTD in 1207.
He was a 13th-century poet, Hanafi faqih, Islamic scholar, Maturidi theologian and Sufi mystic originally from Greater Khorasan in Greater Iran. via @wikipedia
Books by Rumi at PG:
https://www.gutenberg.org/ebooks/author/43130
Thiago Carvalho
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Jean Baptiste Perrin was born #OTD in 1870.
He was a French physicist who, in his studies of the Brownian motion of minute particles suspended in liquids (sedimentation equilibrium), verified Albert Einstein's explanation of this phenomenon and thereby confirmed the atomic nature of matter. For this achievement he was honoured with the Nobel Prize for Physics in 1926. via @wikipedia
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
