Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes https://www.biorxiv.org/content/10.1101/2023.10.04.560818v1?med=mas
Evolution strikes again
"One of the most uncommon hinges of vertebrate Ig is that exclusively found in Antarctic fishes: IgM H chain has a remarkably long hinge region, ranging from 14 to 22 amino acid residues, highly polymorphic, and rich in prolines and glycines (Coscia et al, 2000; Coscia et al, 2011; Coscia et al, 2012). Given these peculiar features, the hinge region has been suggested to provide the cold Ig molecule with higher flexibility to exert its function at very low kinetic energy in the Antarctic environment."
#Preprint #Immunology
https://www.biorxiv.org/content/10.1101/2023.10.04.560855v1.full.pdf
Thiago Carvalho
boosted
STAT+: Failed biotech gives a rare peek inside the tough breaks -- and tough choices -- that led to its demise
'RNA’s fleeting nature isn’t a big problem for a vaccine: it needs to encode proteins only for a short time to trigger an immune response. But for most therapeutic applications, it would be much better to have RNA that could stick around for longer.'
Thiago Carvalho
boosted
Ph.D. position in Plant Molecular Biology
University of Lausanne
Ph.D. position in Plant Molecular Biology - mechanisms of root system development and physiology
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-lausanne-27778-ph-d-position-in-plant-molecular-biology/?feed_id=60832
#ScienceJobs #hiring #research
Lausanne #Switzerland #PhDStudent
https://jobrxiv.org/job/university-of-lausanne-27778-ph-d-position-in-plant-molecular-biology/?feed_id=60832
Bernd has been pushing this point for a while, and I think he is right. Self correction is an important part of the scientific process and journals, funders, and institutions need to do more to encourage it.
'What can journals do to support both self-correction by authors and by the community? We have discussed this matter for a decade at EMBO Press, culminating in a workshop that recommended to make an explicit distinction between an author initiated- and an externally initiated- or even forced retraction. We use the term “withdrawal” for the former and reserve “retraction” for the latter.'
#scientificpublication #ResearchIntegrity
@emboreports
'In a bid to stem the resurgence of sexually transmitted infections, the Centers for Disease Control and Prevention plans to recommend doxycycline, a widely used antibiotic, for use after an unprotected sexual encounter.'
https://www.nytimes.com/2023/10/03/health/doxycycline-syphilis-gonorrhea-chlamydia.html
'Disinformation campaigns — some armed with AI-generated deepfakes — are likely to be rampant in the coming months, says Ulrike Klinger, who studies political communication at the European University Viadrina in Frankfurt (Oder), Germany. “And we cannot monitor them because we don’t have access to data.”
Tools
"CompRELEASE enables complex control of protein secretion and enhances the potential of synthetic protein circuits for therapeutic applications, while minimizing the overall genetic payload."
'The latest vaccine will now be rolled out on a wide scale to the countries in sub-Saharan Africa where children are at the greatest risk from malaria. Oxford university has a manufacturing agreement with the Serum Institute of India'
#Malaria #Vaccine #Immunology
https://www.ft.com/content/4a54139e-7da7-48d2-bba9-487bf88ed811
Thiago Carvalho
boosted
My colleague Sian Ede & I set up a project with Rob at the IGC years ago. You couldn't ask for a better resident artist at a science institute, curious, kind, and very talented.
"I failed all my science subjects at school, so it is slightly ironic that I spend most of my time working within a scientific community."
https://www.science.org/content/blog-post/no-one-ever-asked-monet-if-they-were-false-colors
Thiago Carvalho
boosted
"Data visualizations tell stories. Relatively subtle choices, such as the range of the axes in a bar chart or line graph, can have a big impact on the story that a figure tells. Ask yourself whether a graph has been designed to tell a story that accurately reflects the underlying data, or whether it has been designed to tell a story more closely aligned with what the designer would like you to believe."
(Calling Bullshit, by Carl Bergstrom & Jevin West).
Thiago Carvalho
boosted
Noted #socialist agitator #AdamSmith once wrote, "People of the same trade seldom meet together, even for merriment and diversion, but the conversation ends in a conspiracy against the publick, or in some contrivance to raise prices."
--
If you'd like an essay-formatted version of this thread to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:
https://pluralistic.net/2023/10/04/dont-let-your-meat-loaf/#meaty-beaty-big-and-bouncy
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Thiago Carvalho
boosted
The lung mycobiome & anti-tumor immunity
"Our study revealed that the intratumor mycobiome, albeit at low biomass, plays an important role in stimulating the immunosuppressive TME and thereby promotes lung tumor progression and is associated with poor patient outcome."
#Immunology #MucosalImmunology
https://www.sciencedirect.com/science/article/abs/pii/S153561082300288X
Thiago Carvalho
boosted
"I had worked on mitochondrial DNA in vertebrate cells and in yeast. I became fascinated by the unusual mitochondrial DNA of trypanosomatids, which is a very large network of catenated circles (1). Then, on the side, I discovered this organelle, the glycosome, which contains the whole glycolytic system of the trypanosomatids (4). I still remember the excitement when we found that."
Thiago Carvalho
boosted
Thiago Carvalho
boosted
"Until the age of seventy, nothing I drew was worthy of notice. At seventy-three years, I was somewhat able to fathom the growth of plants and trees, and the structure of birds, animals, insects and fish."
—Katsushika Hokusai, One Hundred Views of Mt. Fuji, 1834
Thiago Carvalho
boosted
This painting is from A. M. Wirth. What is imagined in the painting is a streetselling scene in a nineteenth century urban context. The painting is called "Beim Antiquar", and so you are looking at a second hand trade of an antiquarian. The nineteenth century saw the rise of this trade of used and old books, as #BookHistory knows. But there is a lot of paper present too, so #PaperHistory folks pay attention if you like. Highlighted are the details I am going to address in more length.
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My colleague Sian Ede & I set up a project with Rob at the IGC years ago. You couldn't ask for a better resident artist at a science institute, curious, kind, and very talented.
"I failed all my science subjects at school, so it is slightly ironic that I spend most of my time working within a scientific community."
https://www.science.org/content/blog-post/no-one-ever-asked-monet-if-they-were-false-colors
Thiago Carvalho
boosted
@cyrilpedia Great book, and great teaching module. Every university should teach this.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
