Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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Heat exposure can undermine cognitive health in later life among socially vulnerable populations via @psypost https://www.psypost.org/2023/10/heat-exposure-can-undermine-cognitive-health-in-later-life-among-socially-vulnerable-populations-213926
Thiago Carvalho
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If you're a UK scientist please consider adding your name to this letter to the secretary of state for science regarding her recent remarks on "kicking woke ideology out of science". Thanks!
Thiago Carvalho
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Thiago Carvalho
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"What caricature is in painting, burlesque is in writing; and in the same manner the comic writer and painter correlate to each other; as in the former, the painter seems to have the advantage, so it is in the latter infinitely on the side of the writer. "
The Works of Henry Fielding
English writer and dramatist Henry Fielding died #OTD in 1754. He is known for his rich earthy humor and satirical prowess and as the author of the novel Tom Jones.
I agree, Metz - but I think we're going to need a bigger sticker.
'By the programme’s end in 1942, more than 7,500 unique, and often beautiful, images had been produced. In his short film, the Toronto-based filmmaker Sebastian Ko provides lively flipbook tour through the USDA ‘Pomological Watercolor Collection’ to explore its history and legacy.'
Thiago Carvalho
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Neo-Nazis? The Conservative Party is disintegrating
“As the boundary between the Tories and the radical right breaks down, the party has morphed into something new.”
https://www.newstatesman.com/comment/2023/10/conservative-party-disintegrating
'His enthusiasm rubbed off on many of his visitors, who carried the latest news of Vesuvian experiments with them across the Continent and to America. His investigations culminated in a book describing the ‘fields of fire’ or Campi Phlegraei, as he titled his ‘observations of the volcanos of the two Sicilies’. He spent more than £1300 producing the edition, adding a supplement to cover the eruption of 1779. It was one of the most lavish and expensive publications of the 18th century, marking both a high point and a dead end in Enlightenment vulcanology.'
https://www.lrb.co.uk/the-paper/v45/n19/rosemary-hill/smoke-and-lava
'An aerial view shows a man riding a motorcycle in an empty section of Tefe Lake, which was affected by the drought of the Solimoes river, during a monitoring flight of Chico Mendes Institute for Biodiversity Conservation, near Tefe, Amazonas state, Brazil, on October 4, 2023.'
Bruno Kelly/Reuters
“White folks would rather lose the war than give up the luxury of race prejudice,” Roy Wilkins of the NAACP argued in 1942. The navy, he said, “would rather not have a vital radio message get through than to have it sent by Black hands or over equipment set up by Black technicians.”
https://www.nybooks.com/articles/2023/10/19/we-return-fighting-half-american-delmont/
Thiago Carvalho
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Number of #LongCOVID Cases Could Be Vastly Underestimated
“new research suggests that may be an underestimate and that far more people may be suffering from long #COVID without ever having tested positive for the virus. Researchers found a significant proportion of patients in their small study who had never tested positive for COVID-19 but who were having symptoms of long COVID nevertheless showed evidence of immune responses consistent with previous exposure.”
Thiago Carvalho
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Single-cell omics techniques to elucidate cell-to-cell variability in signaling cascades involved in human diseases https://www.tandfonline.com/doi/full/10.1080/14789450.2023.2268836
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#proteomics #prot-paper
'When Mark Basa needed his next dose of Wegovy, he worked his way down a list of 10 CVS stores within a 25-mile radius of his Peekskill, N.Y., home — and struck out at every one. In the 10 weeks he couldn’t find the drug, he regained the eight pounds he had lost on the medication, and his blood sugar rose. He felt himself get out of breath more often. His shirts fit tighter.'
https://www.nytimes.com/2023/10/05/well/live/wegovy-shortage-ozempic-fda.html
Thiago Carvalho
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Following on from Friday's numbers substack post, I've just done a dive into all the data we used to have about Covid and what it meant.
Hopefully useful when considering what's coming out of the Inquiry about decisions in 2020! We knew a lot!
'However, the connection between phase separation and RTK-driven tumorigenesis is only now beginning to be appreciated. In this opinion article we focus on recent studies linking LLPS and RTK signalling. We provide insight into the possibility of LLPS playing a general role in RTK-driven signalling, especially in cancer, and introduce the prognostic opportunity represented by identification of features of LLPS in patients.'
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(23)00194-0
Thiago Carvalho
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"One of my hobbies is reading really old scientific papers. When I realized that uridine in RNA sets off immune cells, resulting in inflammation and interferon production, I wondered whether anyone had noticed this before. So I went back to the literature. Sure enough, I found a 1963 paper in which the authors reported that RNA isolated from mammalian cells does not induce the production of interferon (5). However, when the RNA was treated with nitrous acid, which deaminates all of the cytidines to uridines, it induced interferons. It gave me great pleasure to see that these researchers had stumbled upon this observation years before."
Thiago Carvalho
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"And in evolutionary terms, species don’t really get a harder problem than the one we have to deal with: Human beings are really, really bad at reproducing ourselves. Even today, with modern medical interventions, our pregnancies and births—and, as a result, our postpartum recoveries—are longer, harder, and more prone to crippling complications than they are for most other primates."
https://www.theatlantic.com/books/archive/2023/10/gynecology-human-ancestors-eve-bohannon/675526/
Thiago Carvalho
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"A razão mais importante para dar a estocada final nesta política é que os impostos estão no cerne da democracia. O ato cidadão de contribuir, cada um na medida das suas possibilidades, para que o Estado possa fornecer serviços públicos e proteger os mais frágeis é fundador da nossa vida em sociedade."
https://www.publico.pt/2023/10/06/opiniao/opiniao/fim-borla-fiscal-rnh-so-acredito-2065725
Thiago Carvalho
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"La trama presuntamente vendía la autoría de estos cientos de estudios falsos a investigadores asiáticos, sobre todo indios y chinos, ávidos por publicar rápidamente para lograr una plaza o un ascenso. La red lograba entonces colar esos pseudoestudios en revistas especializadas de las principales editoriales científicas, como Elsevier, Springer Nature, Wiley y MDPI. Más que aprovechar las grietas del sistema, estaban paseando por una alfombra roja para los tramposos."
Thiago Carvalho
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'In this study, we investigate the role of microbiota-derived acetate in the regulation of O-GlcNAcylation and HCC progression under high fructose consumption. We report that fructose promotes HCC progression by enhancing O-GlcNAcylation via microbiota-derived acetate.'
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00340-6
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
