Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
'The private equity industry is facing a “shakeout” that could result in painful losses for investors who piled into the sector without properly understanding the risks of holding illiquid assets, according to the chief investment officer of one of the world’s largest charitable foundations.'
https://www.ft.com/content/216e1829-a92c-43f7-8dc3-d7e99f68f18c
Thiago Carvalho
boosted
... no amount of investigation of another person’ s neural processes by means of fMRI will allow us to inspect his reasoning or what he is thinking.
Bennett, M. R.; Hacker, P. M. S.. Philosophical Foundations of Neuroscience (p. 107). Wiley. Kindle Edition.
Not great. Gantenerumab is a monoclonal antibody against aggregated Aβ:
"Among persons with early Alzheimer’s disease, the use of gantenerumab led to a lower amyloid plaque burden than placebo at 116 weeks but was not associated with slower clinical decline."
#alzheimers
https://www.nejm.org/doi/full/10.1056/NEJMoa2304430?query=featured_home
Thiago Carvalho
boosted
#IDMastodon #PublicHealth Data from the English Surveillance Programme for #Antimicrobial Use & Resistance (ESPAUR) show a 11.7% increase in patient episodes of #bloodstreaminfections (https://link.springer.com/article/10.1007/s00134-020-05950-6 ) and/or fungemia from 2018 to 2022. The most common causes of monomicrobial BSIs were #Escherichiacoli (20.9%)& #staphylococcusaureus (7.7%). The incidence of Candidemia increased by 22.7%…
Thiago Carvalho
boosted
The increase in #antibiotic use in the community is most likely related to increased healthcare demands in 2022 following the removal of many pandemic-related mitigations.
https://assets.publishing.service.gov.uk/media/6555026e544aea000dfb2e19/ESPAUR-report-2022-to-2023.pdf
Thiago Carvalho
boosted
'A new venture, led by the founder of a biotech group that was sold to Sanofi for up to $1.45bn in 2021, has won £48mn in funding for research into cancer treatments using machine learning and genetically engineered mouse technology.'
https://www.ft.com/content/73c41613-5fc7-499b-9858-2eeb456014bb
Thiago Carvalho
boosted
"There are more Americans who say they have serious cognitive problems — with remembering, concentrating or making decisions — than at any time in the last 15 years, data from the Census Bureau shows."
https://www.nytimes.com/2023/11/13/upshot/long-covid-disability.html
'In this Brief Review, we discuss recent findings that inform the design of the next generation of COVID-19 vaccines. In the context of prior SARS-CoV-2 evolution, we discuss strategies under investigation for the induction of broadly neutralizing Abs (bNAbs) to restrict SARS-CoV-2. Additionally, we examine recent evidence for the importance of mucosal immunity in restricting SARS-CoV-2 transmission. We further consider the challenges associated with these next-generation vaccine strategies, including overcoming “original antigenic sin”'
#covid #Covid19 #sarscov2 #vaccines #Immunology
Thiago Carvalho
boosted
Meanwhile, in Portugal, no trains & more airports:
"The Socialist Workers' Party of Prime Minister Pedro Sánchez has signed a coalition deal with the far-left Sumar party that includes some 230 policy promises covering the next four years — including a pledge to limit short flights within the country."
https://www.politico.eu/article/spain-aims-to-say-adios-to-short-haul-flights/
Thiago Carvalho
boosted
New York Times: "There are more Americans who say they have serious cognitive problems than at any time in the last 15 years, data from the Census Bureau shows. Researchers point to long Covid as a major cause."
You can ignore COVID, but COVID will not ignore you.
Thiago Carvalho
boosted
@CellySally @steveroyle @dn_mason Steve may remember fondly (?) our debates about what to do about the placement of this ⚠️ on our JCS ‘At a Glance’ poster 😆 We settled it by a vote between all co-authors in the end. For the full poster, see: https://journals.biologists.com/jcs/article/136/7/jcs260783/306976/Genetically-encoded-imaging-tools-for
Thiago Carvalho
boosted
The Dana Career Network in Neuroscience & Society East Coast Regional Meet-Up is happening TODAY at 7pm ET. Led by Harvard Professor, Frances Shen, this event will offer guidance on navigating career paths and training opportunities in neuroscience and society. #careerdevelopment #neurosociety Register here: https://harvard.zoom.us/meeting/register/tJIlcuGgqz4uH9FX4IH8nWzy7AURfhqStDKh#/registration
Thiago Carvalho
boosted
The US House voted last night to attach a ban on gain-of-function research to legislation that would fund the NIH and other federal health agencies. Where it will go from here, though, is unclear. My @STAT colleague Sarah Owermohle reports. https://www.statnews.com/2023/11/15/gain-of-function-research-limit/
"Inevitably, people have suggested that pulling a move to restore Cameron to the frontline is like rearranging the deckchairs on the Titanic, but arguably that doesn’t really cover it. This is not like shifting the deckchairs in 1912, an hour after the iceberg had hit, but like doing it now, in 2023, when David Cameron’s form has been largely consumed by molluscs, and fish have been swimming in and out of his cavities, along with the various Treasury committee members who in 2021 probed his lucrative lobbying of ministers on behalf of the now-collapsed Greensill Capital. These days, he’s arguably more reef than man."
https://www.theguardian.com/commentisfree/2023/nov/14/failure-david-cameron-libya-failed-state
'Our results show that neutralizing antibodies in children possess similar genetic features compared to antibodies identified in adults, with multiple antibodies from children belonging to previously established public antibody clonotypes in adults.'
Thiago Carvalho
boosted
Issue 21 is complete
Explore our ToC here: https://journals.biologists.com/jcs/issue/136/21
Our cover features a C. elegans larvae crawling amongst developing early embryos. See the full #OpenAccess article from Sarah Barger, Lauren Penfield & Shirin Bahmanyar: https://journals.biologists.com/jcs/article/136/21/jcs261385/334718/Nuclear-envelope-assembly-relies-on-CHMP-7-in-the
Also in Issue 21:
- Research Highlights on insulin resistance and NE closure
- Interview with Ben Schumann
- 30 years of nanobodies Review
- Review on SETD2 in the CNS
'Although mouse and human MAIT cell transcriptomes showed similarities for immature cells in the thymus, they diverged more strikingly in the periphery. Analysis of pet store mice demonstrated decreased lung MAIT17 cells in these so-called “dirty” mice, indicative of an environmental influence on MAIT cell subsets and function.'
I love this set.
Colin Donnell as Roy Scheider, Ian Shaw as Robert Shaw, and Alex Brightman as Richard Dreyfuss in The Shark Is Broken at the John Golden Theatre, 2023
Photo: Matthew Murphy.
#SetDesign #theater #theaterarts
https://www.nybooks.com/online/2023/11/14/three-men-and-a-shark-jaws/
Thiago Carvalho
boosted
How many trees does your institution have planted in #TheForestOfBiologists, our new biodiversity initiative with support from The Woodland Trust? For each #Research Article or #Review article we publish, we are planting a tree in a UK forest. The Forest of Biologists is a celebration of the work of the scientists whose research and expertise fills our journals, and it is a clear statement of The Company of Biologists’ commitment to sustainability. https://forest.biologists.com/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
