Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
New post looking ahead at what's in store for the NHS this winter.
TLDR it's not pretty but I suspect we'll about last year's disaster but*only* because we avoid a triple peak of covid, RSV and flu in December.
That 'select' has been the problem for the last decade
"These results suggest that programmed cell death protein 1 blockade may benefit a select group of patients with brain metastases, and support further studies to identify biomarkers and mechanisms of resistance."
#Immunology #Immunotherapy
Thiago Carvalho
boosted
'Pocone, Brazil
A group of caimans sit on the banks of the almost dried-up Bento Gomes river in the Pantanal wetlands.
Photograph: André Penner/AP'
Thiago Carvalho
boosted
ICYMI on Wednesday, "Genetic Dissection of the TLR Paradox in SLE", a very interesting 'Global Immunotalks' seminar by Mark Shlomchik.
#Immunology
Joan Jara (1927-2023)
"No dia em que o Chile sofreu um golpe de Estado perpetrado por Augusto Pinochet, com o apoio dos Estados Unidos, a 11 de Setembro de 1973, Joan e Victor Jara ouviram em casa, pela rádio, a última comunicação do presidente Salvador Allende, que morreria pouco depois no Palácio de La Moneda, na capital do país. No final da comunicação, ele saiu para se juntar aos protestos numa universidade e esperar o desenrolar dos acontecimentos. “Não olhei para o ver partir. Não parecia importante. Disse adeus de forma habitual. Foi a última vez que o vi”, contou, décadas depois, Joan Jara ao britânico The Guardian. Uma luta diferente começava ali para ela."
Thiago Carvalho
boosted
Time to delete our Research Gate accounts. #PredatoryPublishing sucks.
Time traveling to 1997, the Post covering the arrival of effective combination therapy for HIV. I like particularly like this bit:
'But David Ho didn't invent protease inhibitors. He is just one of a group of major international researchers, dubbed the "new guard" by the science press, who played a role in exploring their possibilities. And he is the first to acknowledge that the drug companies themselves -- usually the least likely source of groundbreaking science -- did most of the heavy lifting. "The feeling in the labs," recalls Merck CFO Judy Lewent, "was that this was Nobel laureate caliber work. And, in the drug industry, we don't get to think about that all too often."'
“Here’s a thing that always happens with money,” Goldstein wrote. “Whatever money is at a given moment comes to seem like the natural form money should take, and everything else seems like irresponsible craziness.”
https://www.noemamag.com/what-if-money-expired/?ref=thebrowser.com
Thiago Carvalho
boosted
Marine invertebrate larvae are incredibly diverse.
Sample of the diversity of animal larval forms. Larvae are not to scale. Photos from the Cifonauta database (Migotto and Vellutini, 2011).They have all sorts of unique features—tentacles, lobes, bands of cilia, shells, bristle hairs, etc.—which they use to capture food, to swim, to protect themselves from predators.
Their morphology is functional. But also beautiful.
That’s why I was excited to discover these larval stickers made by Dexter Davis:
Larval stickers Sheet 1 (left) and Sheet 2 (right) from NoDexterity.They represent the larval diversity very well and are cutely drawn. A great biology-inspired design.
Now my laptop lid is filled with my favorite larvae:
Larval stickers from left to right and top to bottom: bipinnaria (pink), tornaria (light green), trochophore (orange), doliolaria (blue), zoea (yellow), cydippid (green), echinopluteus (purple), actinotroch (cyan), pilidium (light green), ophiopluteus (yellow), cyphonautes (green), parenchymella (beige), brachiolaria (red), veliger (purple), mitraria (cyan), tegulolopha (green), actinula (yellow), and auricularia (light orange). The other stickers are Fiji‘s logo, xkcd‘s science and citation needed, Darwin’s tree, Kurzgesagt‘s illustrations, Aygan‘s logo, WoRMS‘ logo, MPI-CBG‘s logo, and fruit flies.
Thiago Carvalho
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"In short, the animal and vegetable lines, diverging widely above, join below in a loop."
Natural science and religion
American botanist Asa Gray was born #OTD in 1810. His most widely used book, Manual of the Botany of the Northern United States, from New England to Wisconsin and South to Ohio and Pennsylvania Inclusive (1848), commonly called Gray’s Manual, has remained, in successive editions, a standard work in this subject.
Books by Asa Gray at PG:
https://www.gutenberg.org/ebooks/author/1757
Thiago Carvalho
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Publico en mi blog #gen_ética en @naukas_com un artículo explicando cómo funciona la primera terapia #CRISPR que ha sido aprobada en el Reino Unido para tratar a pacientes de anemia falciforme y beta-talasemia. Un nuevo éxito de la investigación básica.⬇️
https://montoliu.naukas.com/2023/11/18/y-al-fin-se-aprobo-la-primera-terapia-basada-en-crispr-en-el-reino-unido/
ICYMI on Wednesday, "Genetic Dissection of the TLR Paradox in SLE", a very interesting 'Global Immunotalks' seminar by Mark Shlomchik.
#Immunology
Thiago Carvalho
boosted
This cartoon illustrates the real problem with our #NHS #mentalhealth services, the physical ones too.
We expect our health service to be the "support of last resort" for the devastating effects that modern society has on all of us. We can't save the NHS and make it all it can be without fundamental changes in our sick and broken society.
It can start by paying nurses and other workers what we're worth.
Thiago Carvalho
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Stroke presents differently in women than men. Here are 7 symptoms to look for.
“some less noticeable signs of stroke seen in women include severe headache, generalized weakness, generalized fatigue, shortness of breath and chest pains, nausea and vomiting, brain fog and hiccups.”
#Stroke #Women #Medicine
Thiago Carvalho
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"Using this strategy, the origin of the calculating paradigm in Europe can be traced to the introduction of Arab mathematics during the late Middle Ages. The epicenter was northern Italy. This was where Leonardo of Pisa’s Liber Abaci was published in 1202, and from the thirteenth century onward the region saw widespread adoption of Hindu-Arabic numerals and attendant methods for calculation and problem solving."
https://worksinprogress.co/issue/how-mathematics-built-the-modern-world
Thiago Carvalho
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Paloma! Prato falante. Glazed #stoneware by @hunchbacksociety
#proverbs #proverbios #ceramics #plate #pottery #artgallery #artmastodon
Thiago Carvalho
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"That brings us to the star of our show. The Nordic-European Initiative on Colorectal Cancer (NordICC) is a huge randomized trial aimed at rigorously measuring how much colonoscopies reduce cancer and death"
Thiago Carvalho
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Dormant bacterial spores encrypt a long-lasting transcriptional program to be executed during revival https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00844-4?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Thiago Carvalho
boosted
BTW a word about our old digital home, Twitter. Space Karen keeps fucking up that shithole Xcrement whatever he calls our X. After losing 15% of users & half of revenues in his first year, he just angered a series of major advertisers like IBM, Lionsgate, Apple etc. Elmo is the Eric Trump of tech
Thiago Carvalho
boosted
Portugal just ran on 100% renewables for six days in a row
> For nearly a week, the country of 10 million met customer needs with wind, hydro and solar — a test run for operating the grid without fossil fuels.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
