Thiago Carvalho @cyrilpedia@social.cleverlibre.org

From @RELenski post, How to Write a Response to Reviewers in Ten Easy Steps:

"Pay special attention to comments where two (or more) reviewers comment on the same issue. If they both agree (for example, they tell you to clarify or delete some passage), then that is almost certainly something you should do"

https://telliamedrevisited.wordpress.com/2020/07/15/how-to-write-a-response-to-reviewers-in-ten-easy-steps/

"Double Villain”, Prato falante.
Glazed #stoneware by @hunchbacksociety

#proverbs #proverbios #ceramics #plate #pottery #artgallery #artstagram #handmade #ceramic

https://hunchbacksociety.cargo.site

This year I finished one of the most fascinating projects I ever worked on.

Together with a team of researchers from the molecular neurodegeneration department at Amsterdam UMC we came up with a visual and interactive way to present their latest paper on tau protein aggregation and its effect on astrocytes.

🧵
#neuroscience #dementia #alzheimers #science #scicomm #design #UI #gamedev #ScienceMastodon #visualStorytelling #astrocytes

An Ancient Art Form Topples Assumptions about Mathematics | Scientific American
https://www.scientificamerican.com/article/an-ancient-art-form-topples-assumptions-about-mathematics/

Distance-AF: Modifying Predicted Protein Structure Models by Alphafold2 with User-Specified Distance Constraints https://www.biorxiv.org/content/10.1101/2023.12.01.569498v1.full.pdf+html

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#proteomics #prot-preprint

This one has it all: mystery western blot bands, red blood cells, pandemic disruptions, grumpy reviewers 🎧👇

#SciComm #SciencePodcast #EMBOPodcast

https://www.embo.org/podcasts/the-band-and-the-rhythm/

"Here, we summarize the latest insights into cellular uptake mechanisms and pathways in DCs. We highlight the approaches to study endocytosis, the impact of endocytosis routes on T cell response, and discuss the link between how DCs internalize therapeutic antibodies and the potential mechanisms that could give rise to immunogenicity"

https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250340

"We hypothesized that elevated Gαq stimulation within the syncytiotrophoblast layer contributes to the pathogenesis of #preeclampsia through disruption of normal redox balance and thus the induction of syncytiotrophoblast stress."

https://www.science.org/doi/10.1126/sciadv.adg8118

"The book wasn’t published for two years, not before perestroika and Gorbachev. “After reading your book no one will fight,” the censor lectured me. “Your war is terrifying. Why don’t you have any heroes?” I wasn’t looking for heroes. I was writing history through the stories of its unnoticed witnesses and participants. They had never been asked anything."
- Svetlana Alexievich

https://www.nobelprize.org/prizes/literature/2015/alexievich/lecture/?ref=thebrowser.com

Buster Keaton's "The General" at one of Lisbon's most special spots, a Cinemateca Portuguesa. Bonus: accompanied by a live pianist.

http://www.cinemateca.pt/Entrada.aspx

AlphaFold & PDL1

"Here, we test a protein design pipeline that uses iterative rounds of deep learning (DL)-based structure prediction (AlphaFold2) and sequence optimization (ProteinMPNN) to design autoinhibitory domains (AiDs) for a PD-L1 antagonist."
#Immunology #CheckpointInhibitor

https://www.pnas.org/doi/10.1073/pnas.2307371120

In Portugal, as everywhere else in the world, if men could not vote, there would be no far right problem.

"(...) o Ch*ga é claramente mais masculino (mais oito pontos do que entre elas)."

https://www.dn.pt/politica/ps-alarga-distancia-para-o-psd-e-chega-nao-para-de-crescer-17439021.html

Labour peers urged to back fatal motion and protect worker's right to strike

"It's unthinkable, it's unworkable, it's almost certainly illegal and even worse the government is willing to outright lie to the public to get away with it"

https://www.thelondoneconomic.com/politics/labour-peers-urged-to-back-fatal-motion-and-protect-workers-right-to-strike-364345/

Postdoc in Host-microbe interactions – computational and/or experimental

Cornell University

See the full job description on jobRxiv: https://jobrxiv.org/job/cornell-university-27778-postdoc-in-host-microbe-interactions-computational-and-or-experimental-3/?feed_id=66864

#ScienceJobs #hiring #research
Ithaca, NY #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/cornell-university-27778-postdoc-in-host-microbe-interactions-computational-and-or-experimental-3/?feed_id=66864

These fuckers are content to watch us die.

This bullshit is going to condemn our species to extinction unless we find a way to depose these sociopaths.

https://www.theguardian.com/environment/2023/dec/03/back-into-caves-cop28-president-dismisses-phase-out-of-fossil-fuels

#cop28 #copOut #ClimateEmergency #ClimateCrisis #ClimateChange

PROTEOME-SCALE RECOMBINANT STANDARDS AND A ROBUST HIGH-SPEED SEARCH ENGINE TO ADVANCE CROSS-LINKING MS-BASED INTERACTOMICS https://www.biorxiv.org/content/10.1101/2023.11.30.569448v1.full.pdf+html

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#proteomics #prot-preprint

https://twitter.com/DavidCayJ/status/1731060313158537625/photo/1

Message from the Boss.