Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Lab Operations Manager
St. Jude Children's Research Hospital
the Kellogg lab seeks a proactive and organized Lab Manager with strong communication skills to keep the lab research program running smoothly.
See the full job description on jobRxiv: https://jobrxiv.org/job/st-jude-childrens-research-hospital-27778-lab-operations-manager/?feed_id=68605
#bioengineering #crispr #genomics #mic...
https://jobrxiv.org/job/st-jude-childrens-research-hospital-27778-lab-operations-manager/?feed_id=68605
"And authors discovered their books had been pirated by corporations whose billionaire investors cried poverty at the suggestion they should pay even a penny in compensation. Artists’ anger turned to strikes and lawsuits."
"God's Garden. Top 101. Kanagawa, Ashinoko Lake, Japan. #
Takahiro Gamou / The Tenth International Landscape Photographer of the Year"
Thiago Carvalho
boosted
Multimodal Large Language Models are Generalist Medical Image Interpreters https://www.medrxiv.org/content/10.1101/2023.12.21.23300146
Thiago Carvalho
boosted
Effect of #tecovirimat in human #mpox. This study predicts the impact of early tecovirimat administration on the time to viral clearance in patients with mpox infection, using integrative modeling that combines preclinical & clinical data #PLOSBiology https://plos.io/484IfX6
Thiago Carvalho
boosted
Leveraging ancestral sequence reconstruction for protein representation learning https://www.biorxiv.org/content/10.1101/2023.12.20.572683v1.full.pdf+html
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#proteomics #prot-preprint
Thiago Carvalho
boosted
Multiphoton imaging through 20 mm of air with the new Cousa objective.
This is a new type of objective: ultra long working distance, huge field-of-view, optimized for two-photon imaging.
And it fits on standard microscopes neuroscientists use for in vivo imaging (e.g., from Bruker, Thorlabs, Neurolabware, INSS, CoSys, etc.)!
The Cousa provides excellent data and even three-photon imaging over a huge field-of-view!
The paper has data from marmosets, tree shrews, both young and adult ferrets, intact pig eye, the first in vivo calcium imaging from mouse cochlear hair cells (!), beautiful input mapping / dendritic spine imaging, and more!
The paper was published just now: https://doi.org/10.1038/s41592-023-02098-1 It's open access. The Cousa objective can be purchased from a company that is being spun out of the lab: https://pacificoptica.com
"Most human genome assemblies provide a record of this ancient evolution, but fail to resolve ongoing LINE-1 retrotranspositions. Utilizing the human CHM1 long-read-based haploid assembly, we identified and cloned all full-length, intact LINE-1s, and found 29 LINE-1s with measurable in vitro retrotransposition activity."
https://www.embopress.org/doi/full/10.1038/s44318-023-00007-y
Thiago Carvalho
boosted
Alt : The ennemy doesn't arrive by boat.
He arrives by limousine.
Fr : L'ennemi n'arrive pas par bateau
Il arrive en limousine.
"Exercise rapidly induced expansion of the muscle Treg compartment, thereby guarding against overexuberant production of interferon-γ and consequent metabolic disruptions, particularly mitochondrial aberrancies."
#Immunology
"I love great books on the process of creating. Hard to beat Robert Caro’s “Working” — in which he shares not only his experiences getting the story, the depth and quality of his research, but also the time and effort he takes in the actual writing, to get the language perfect, and to weave the facts into a tapestry that is as thrilling to the reader as it was in real life."
https://www.nytimes.com/2023/12/21/books/kathy-hourigan-interview-knopf.html
Thiago Carvalho
boosted
Data released by Springer Nature highlights clear need for greater research integrity training
Just over half of UK and US researchers taking part in Springer Nature's latest research integrity survey reported they had access to research integrity training, compared to nearly 70% of Australian respondents. However, the need for such training was recognised across the board. To read the full article, visit: https://zurl.co/4JsY
#Research #Integrity #Training
Theory of mind on a plate.
#PratoFalante
Glazed #stoneware by @hunchbacksociety
#art #ceramics #plate #pottery #artgallery #handmade #artmastodon
@madparreira.bsky.social
Thiago Carvalho
boosted
In their #JEB100 Review, Fleur Ponton & co discuss how the field of nutritional immunology captures the complex connections between the nutritional environment, infection & immunity, and the research linking the nutritional environment with insect health.
https://journals.biologists.com/jeb/article/226/24/jeb245714
'I asked a couple of A.I. programs to “write a six-word story about baby shoes,” riffing on the famous (if apocryphal) Hemingway story. They failed but not in the way I expected. Bard gave me five words, and ChatGPT produced eight. I tried again, specifying “exactly six words,” and received eight and then four words. What did it mean that A.I. could best top-tier lawyers yet fail preschool math?'
"Through tissue-specific manipulation of Nptx2, the authors demonstrated that the pituitary was a major source of NPTX2 in the serum, and the increased NPTX2 secretion by the pituitary affected immune balance by regulating the blood neutrophil-to-lymphocyte ratio. Intriguingly, Nptx2 up-regulation in corticotropes seemed to depend on IL-6 but not other cytokines tested."
#Immunology #Neuroimmunology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002440
Thiago Carvalho
boosted
O Pesadelo do Moedas
"Broad, tranquil avenues of tall trees link parks, squares and allotments, forming a circular oasis around a city centre that itself is largely car-free and where, aside from a passing tram, the dominant sound is conversation, birdsong and even the persistent chirping of cicadas."
https://www.theguardian.com/environment/2023/dec/20/vitoria-gasteiz-spanish-city-rejected-cars
Thiago Carvalho
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"The disruption this year in supplies of key chemotherapy drugs has realized the worst fears of patients — and of the broader health system — because some people with aggressive cancers have been unable to get the treatment they need."
https://www.nytimes.com/2023/12/19/health/cancer-drug-shortage.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
