Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Film studios demand IP addresses of people who discussed piracy on Reddit

Reddit says First Amendment rights protect it from having to disclose users' info.

https://arstechnica.com/tech-policy/2024/01/film-studios-demand-ip-addresses-of-people-who-discussed-piracy-on-reddit/?utm_brand=arstechnica&utm_social-type=owned&utm_source=mastodon&utm_medium=social

"However, IL-2’s effectiveness is hindered by its pleiotropic nature, because its receptor is found on various immune cells, including regulatory T (Treg) cells and natural killer (NK) cells, which can counteract antiviral responses or contribute to toxicity, respectively. To address this, we developed a cis-targeted CD8-IL2 fusion protein, aiming to selectively stimulate dysfunctional CD8+ T cells in chronic HBV. In a mouse model, CD8-IL2 boosted the number of HBV-reactive CD8+ T cells in the liver without substantially altering Treg or NK cell counts."
#Immunology

https://www.science.org/doi/10.1126/scitranslmed.adi1572

"In 1988, physician scientists discovered LINE-1 insertional mutations in the blood-clotting gene factor VIII in two unrelated individuals with hemophilia, providing the foundation that LINE-1 is an active mobile element in humans (Kazazian et al. 1988). In the 35 yr since this landmark discovery, >100 LINE-1-mediated insertional mutations resulting from germline retrotransposition have been shown to cause human genetic diseases (Hancks and Kazazian 2016). In each example, LINE-1 activity inserted a retrotransposon sequence at a critical gene sequence and caused a loss-of-function allele."

https://genesdev.cshlp.org/content/37/21-24/948.full

"lthough not observed in mouse ILC2s, we found that human ILC2s secrete granzyme B (GZMB) and directly lyse tumor cells by inducing pyroptosis and/or apoptosis, which is governed by a DNAM-1−CD112/CD155 interaction that inactivates the negative regulator FOXO1."
#Immunology

https://www.cell.com/cell/fulltext/S0092-8674(23)01347-8?rss=yes

Snacks
#Kyoto

"A painter is like the pilot of a small boat—constantly correcting course, ever alert to changes in the weather, trying not to get swamped by the wakes of larger boats, steering toward the distant shore. A lifetime of painting requires more than just will; agility of mind helps. “Alex Katz: Gathering,” the artist’s long-awaited retrospective at the Guggenheim Museum, was both Olympian in scale and outlook and a hard-charging athletic event, sweeping in scope yet light on its feet."

https://www.nybooks.com/articles/2024/01/18/follow-the-light-alex-katz-gathering/

"This year, countries with a combined population of 4 billion — around half the world’s people — are holding elections, in what is being described as the biggest election year in recorded history. Some researchers are concerned that 2024 could also be one of the biggest years for the spreading of misinformation and disinformation."

https://www.nature.com/articles/d41586-024-00030-x

#JustforFun: We’ve been lucky enough to have fabulous cover images on @J_Cell_Sci in 2023. We’d like to take one more opportunity to celebrate these images and the research behind them. We invite you to pick your favourite cover here: https://focalplane.biologists.com/2024/01/12/vote-for-your-favourite-jcs-cover-from-2023/

#Pulsars are magnetized, rotating neutron stars. Beams of radiation from their magnetic poles swipe past the observer, resulting in characteristic pulsing radio patterns.

The fastest pulsar we know, PSR J1748−2446ad, rotates at 716 times/sec or 43000 times/min.

You can listen to some of the pulsars here - the intensity of the radio waves as the amplitude of the audio:
▶️ https://www.jb.man.ac.uk/~pulsar/Education/Sounds/sounds.html
Not the 715 Hz one, but the 173.7 Hz (careful, annoying sound!)

#astrodon #VicisAstro #astronomy

Seq-InSite: sequence supersedes structure for protein interaction site prediction https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btad738/7517105?rss=1

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#proteomics #prot-paper

Fantastic discovery !

Huge ancient city found in the Amazon challenges the Eurocentric view of civilisation and shows that ancient people lived in sophisticated urban societies in the Amazon, not just in small nomadic groups.

The city consisted of thousands of rectangular platforms arranged around plazas, connected by straight roads and canals2. Some of the features are unprecedented in South America.

https://www.bbc.co.uk/news/science-environment-67940671?at_medium=RSS&at_campaign=KARANGA

#archeaology #civilizations

Brexit: New report suggests UK £311bn worse off by 2035 due to leaving EU
https://news.sky.com/story/brexit-new-report-suggests-uk-311bn-worse-off-by-2035-due-to-leaving-eu-13046256
The report came up with a scenario for growth if the UK had stayed inside the EU, and compared it to forecasts the Office for Budget Responsibility made in March last year.

Brexshit was always a stupid idea!

Now we need to find politicians brave enough, and/or not in the pockets of the Brexiteers, to take us back into the EU

#Brexit #BrexitDividend #BrexitHasFailed