Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
"Among those who took inspiration from King was Medgar Evers; they and Malcolm X formed what James Baldwin called the great trio of the civil rights movement. The connection between Evers and King has been lost to history. These two men, close in age but working for different organizations with different approaches to the civil rights movement, intersected in ways that lay bare the challenges the movement faced, particularly in the South, as it balanced the competing interests of Black Americans in cities with those of rural sharecroppers, donors, competing civil rights groups and politicians in Washington."
https://www.nytimes.com/2024/01/14/opinion/martin-luther-king-medgar-evers.html
Thiago Carvalho
boosted
Smallpox vaccine efficiently induces immunity against monkeypox virus infection in people living with HIV, study finds
https://www.sciencedaily.com/releases/2024/01/240112114749.htm
> Researchers from the Infection Biology Lab at the Department of Medicine and Life Sciences (MELIS) at Pompeu Fabra University and the HIV Unit at Hospital del Mar Research Institute have shown that intradermal vaccination with the JYNNEOS vaccine against smallpox is the best option to protect people living with HIV from contracting the monkeypox virus. This route of vaccine administration requires less material to inject each patient, extending the available vaccine doses by a factor of five. The results of this observational study also indicate that individuals with a low level of CD4 T cells, a type of white blood cell essential to properly fight new infections, need a booster dose 28 days after the first dose to compensate for their immunosuppressed status.
🔗 Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination (December 2023) https://onlinelibrary.wiley.com/doi/10.1002/jmv.29317
Thiago Carvalho
boosted
When Vaccine Fears Mimic SNL Skits: Magnetic People by Dr Paul Offit.
Unfortunately the nonsense spewed by anti-vax trolls and con artists can actually lead to deaths.
#VaccinesSaveLives #Vaccines #FactsMatter #Science #ScienceUpFirst
https://pauloffit.substack.com/p/when-vaccine-fears-mimic-snl-skits
Thiago Carvalho
boosted
ATP-Binding Free Energy Simulations Reveal an Allosteric Link Between the Enzyme Active Site and Multiple Functional Protein-Protein Interaction Interfaces in Cyclin Dependent Kinase-1 https://www.biorxiv.org/content/10.1101/2024.01.15.575662v1?med=mas
Thiago Carvalho
boosted
Ofcom ‘watching’ as EU investigates #Twitter/X for illegal content #DSA #OnlineSafetyAct
https://www.thetimes.co.uk/article/4150a92c-edf0-4da0-800d-8d8e750f086a?shareToken=0654c1e00d965780931964192d367ff0
'The system that Romero’s team created is powered by a relatively simple machine-learning model that relates a protein’s sequence to its function, and proposes sequence changes to improve function. It delivers protein sequences for testing to lab equipment that makes the protein, measures its activity and then feeds the results back to the model to guide a new round of experiments. “We set and forget it,” Romero says.'
Thiago Carvalho
boosted
.@julia_doubleday is among the best writers out there on COVID, long COVID, and common sense precautions. You should read her latest on air filtration, a no brainer in any move forward in this post-COVID universe: https://www.thegauntlet.news/p/learning-to-live-with-covid-means?utm_source=post-email-title&publication_id=1173135&post_id=140626628&utm_campaign=email-post-title&isFreemail=true&r=e9nn&utm_medium=email
"To experimentally test the idea of ‘accidental virulence’, replicate populations of Saccharomyces cerevisiae were evolved to attach to a plastic bead for hundreds of generations. Along with plastic adherence, two multicellular phenotypes— biofilm formation and flor formation— increased; another phenotype, pseudohyphal growth, responded to the nutrient limitation. Thus, experimental selection led to the evolution of highly-adherent, hyper-multicellular strains."
Thiago Carvalho
boosted
Fun times at #ScientificReports 🤣🙄⬇️ Next time I hear people complainibg that preprints do not really count, because are not peer reviewed... "Let me tell ya about that love story in Sci Rep"...
‘Nonsensical content’: Springer Nature journal (ie Scientific Reports) breaks up with a paper on a love story – Retraction Watch
https://retractionwatch.com/2024/01/14/nonsensical-content-springer-nature-journal-breaks-up-with-a-paper-on-a-love-story/
"Só quem não vai ao Martim Moniz pode deixar-se impressionar pela narrativa de que é uma zona perigosa. Desafio qualquer pessoa a atravessar sozinha as ruas adjacentes e a praça. A menos que considerem desagradável ver tantos estrangeiros juntos."
https://www.publico.pt/2024/01/15/sociedade/opiniao/medo-martim-moniz-2076795
Thiago Carvalho
boosted
"The three-year fellowship provides Ph.D.s from data science, computer science, physics, mathematics, and many other fields the mentorship and support to pursue their own research interests with our data.
Applications for the Fall 2024 cohort are due on February 1st, 2024."
https://alleninstitute.org/careers/internships-and-postbac/shanahan-foundation-fellowship/
Thiago Carvalho
boosted
City:
MLK speaking to a crowd before a march for quality integrated education, Chicago (1965)
Photo: Chicago Sun-Times
Thiago Carvalho
boosted
Consultora PwC acusada de facilitar gestão danosa de Isabel dos Santos
https://onovo.sapo.pt/noticias/consultora-pwc-acusada-de-facilitar-gestao-danosa-de-isabel-dos-santos/
🐦🔗: https://nitter.cz/AnaMartinsGomes/status/1747005071009669229#m
[2024-01-15 21:17 UTC]
"And for Christmas I got whooping cough. The diagnosis was a shock, not only due to the violence of the paroxysms that visited me in the night, but because I’d blithely assumed the thing had pretty much been vaccinated out of existence in the UK."
https://www.ft.com/content/a25bbf59-aa24-4313-a731-ef53976d1933
Thiago Carvalho
boosted
I've written up a checklist to ask before starting any data or bioinformatics project! Four questions I've learned to ask
https://philippbayer.github.io/blerg/posts/2024_01_14_my_data_checklist/
Thiago Carvalho
boosted
In Japan, snakes have long been regarded as magical creatures. Uwabami is a yokai that resembles a normal snake but is known to have a vast appetite and to feed on humans. They also like a drink and can consume vast amounts of sake.
#MythologyMonday #yokai #folklore #JapaneseFolklore
🎨 Matthew Meyer
Thiago Carvalho
boosted
Surprise du jour
"A data scientist promoted by the rightwing activist Christopher Rufo, the Manhattan Institute thinktank, and other conservatives as an expert critic of the former Harvard president Claudine Gay has co-authored several papers in collaboration with a network of scholars who have been broadly criticized as eugenicists, or scientific racists."
Thiago Carvalho
boosted
"We show that mice lacking adaptive immune cells (rag−/− mice) do not develop clinical signs or weight loss from SARS-CoV-2 MA10 infection, whereas fully immunocompetent wild-type (WT) mice develop disease. While rag−/− mice had little to no lung pathology, virus levels were lower than WT mice early after infection, but not significantly decreased within 2 weeks of infection."
#Immunology #Virology #sarscov2
Thiago Carvalho
boosted
My latest paper is now out in @J_Cell_Sci : https://journals.biologists.com/jcs/article/137/1/jcs261567/341218/Believing-is-seeing-the-deceptive-influence-of
Many thanks to my co-authors Leanna, Satya, Jesse, Leong, and to the entire @AICjanelia team for their feedback!
Every stage of a #microscopy project requires decisions, and those decisions are prone to #bias. In this paper, we use illustrative examples to describe potential pitfalls, and also provide strategies for mitigating bias.
You can also check out the data underlying our paper here: https://t.co/JqWOf5RedG
Thiago Carvalho
boosted
Systematic #detection of #coinfection and intra-host #recombination in more than 2 million #global #SARS-CoV-2 samples https://www.nature.com/articles/s41467-023-43391-z
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
