Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"We generated mice for the B cell–conditional expression of the most frequent BTG1 mutation [Gln36→His (Q36H)]. Btg1Q36H cells almost completely outcompeted their wild-type counterparts, specifically in the GC. This competitive fitness manifested as a stronger induction of MYC-dependent growth programs."
#immunology

https://www.science.org/stoken/author-tokens/ST-976/full

"For these reasons, we hypothesize that PTMs could have been selected throughout evolution at the flanks of aggregation-prone regions as an intrinsic factor to protect proteins against aggregation, thus expanding the current repertoire of aggregation gatekeepers."

https://www.science.org/doi/10.1126/sciadv.adk8173

"Fanon wrote at the height of the Cold War, but, with no less prescience, he regarded the East-West struggle as a passing sideshow, of far less consequence than the divisions between North and South, of the rich world and the poor world. If the colonial world was, in his words, “a world cut in two,” our postcolonial world seems scarcely less so. Just consider the starkly different responses to the wars in Ukraine and Gaza — or South Africa’s case against Israel, on the charge of genocide — in the global north and the global south."

https://www.nytimes.com/2024/02/02/opinion/frantz-fanon-colonialism.html

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NASA engineers when their probe slams smack into the tetrahedron

Researchers use supercomputer to determine whether 'molecules of life' can be formed naturally in right conditions.

#evolution #origins_of_life #AI

https://phys.org/news/2024-02-supercomputer-molecules-life-naturally-conditions.html

Scientists investigate the potential of sustainable #legume #protein production in Switzerland.

#agriculture #sustainability

https://phys.org/news/2024-02-scientists-potential-sustainable-legume-protein.html

My conversation with Katalin Karikó, the 2023 Nobel laureate for discovery of the mRNA platform. It's hard to imagine a more inspiring story!
https://erictopol.substack.com/p/katalin-kariko-the-unimaginable-obstacle
Ground Truths podcasts are now on Apple and Spotify

After 8+ incredible years at @ASAPbio I am beginning a new chapter as Open Science Program Director at Astera Institute later this month. So, we're looking for new leadership: please share the posting with people passionate about open science! https://asapbio.org/job-posting-executive-director-of-asapbio-deadline-feb-19

“We can still fix the housing crisis: here’s how”

Excellent article in The Star that covers the causes of Toronto’s housing crisis. From insufficient supply of both non market and market housing, to cessation of purpose built rental, to services downloaded from feds and provide, to increased immigration.

Points to Sweden having had similar crisis in early ‘60s. Solved by ambitious 10 year housing plan.

https://www.thestar.com/business/regular-families-will-never-again-be-able-to-buy-a-house-in-toronto-but-we/article_fa75e335-1cc3-5057-8d05-7c6068c4cbc4.html

#HousingCrisis #Toronto #ToPoli #Housing #OnPoli

Enhanced Electrophoretic Depletion of Sodium Dodecyl Sulfate with Methanol for Membrane Proteome Analysis by Mass Spectrometry https://www.mdpi.com/2227-7382/12/1/5

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#proteomics #prot-paper

"If we want to understand leadership, and how it works in the world, should we be looking primarily at the ways the leader changed the world? Or should we focus on the ways in which the world produced, and then constrained, the leader?"
v. @cyrilpedia
https://aeon.co/essays/who-are-the-leaders-in-our-heads-and-how-did-they-get-there

Conformational transitions and activation of the adhesion receptor CD97 https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)01039-0?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Katalin Karikó: The unimaginable, obstacle-laden, multi-decade journey to discover the mRNA platform and win the 2023 Nobel Prize
#Science #COVID19 #mRNAVaccines #Vaccines

https://erictopol.substack.com/p/katalin-kariko-the-unimaginable-obstacle

What’s in your prenatal vitamins?

“Some supplements are needed, and prenatal vitamins are one of the best examples. Unfortunately, they are also a great example of why products need to be tested and safe because pregnant people shouldn’t have to play folic acid, vitamin, and heavy metal roulette. We need more studies to understand how common contamination is with these products and how often they deviate from the amounts listed on the labels”
#Pregnancy #Vitamins
https://vajenda.substack.com/p/whats-in-your-prenatal-vitamin

#Arctic air temperature rank by month over the satellite era - now updated through January 2024

+ Ranks: 1=warmest (red), 45/46=coldest (blue)
+ Download visual: https://zacklabe.com/arctic-temperatures/
+ Data from: https://psl.noaa.gov/data/gridded/data.ncep.reanalysis.html