Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
First in human trial of CRISPR edited neoantigen specific tumour infiltrating lymphocytes. NeoTCR-transgenic T cells were detected in tumour biopsies and toxicity mainly from lymphodepletion and CRS. Showed feasibility of using a neoantigen specific gene editing approach to TIL therapy
https://www.nature.com/articles/s41586-022-05531-1
'Young life science researchers are leaving academia at unprecedented levels for lucrative jobs in the private sector. Like Gorashi, many of them are entering graduate programs already knowing they don’t want to remain in academia long-term, making their time in the ivory tower a pit stop rather than a final destination.'
On vaccine development as a way out of the antibiotic resistance crisis:
"Of the six bacteria that are responsible for the most deaths linked to drug-resistance — a combined 929,000 fatalities per year — there is a licensed vaccine for just one: Streptococcus pneumoniae, which can cause pneumonia and other illnesses."
#Antibiotics #AntibioticResistance #Microbiology #Immunology #vaccine
https://www.ft.com/content/1bbbdaf5-ea2a-44f4-8640-e24b32d5cfb1
Forensic work showing how the Covid19 vaccine patent waiver proposal was killed.
"Big Pharma used its vast lobbying and influencing efforts to try to kill a proposal that threatened the very tenets of the industry. Top industry executives enjoyed direct access to senior officials within the EU, which was opposed to the proposal from the very start and encouraged potentially rogue member countries, including Italy and France, to fall into line. And the U.S., after a dramatic late intervention in favor of a waiver for vaccines, eight months after the proposal had been tabled, failed to follow through as the Biden administration came under pressure from industry and Congress, as reported by the Intercept."
Thiago Carvalho
boosted
Evidence for sustained evolution of SARS-CoV-2 in white-tailed deer and of deer-to-human transmission. Damn.
Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission | Nature Microbiology
Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.
New work from Abe et al shows that
"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."
Thiago Carvalho
boosted
WHO has upgraded its risk assessment of Uganda's #Ebola outbreak from high to very high on the national level and from low to high for the region.
The perception of increased risk comes from having cases in Kampala and the mobility of some of the cases & contacts.
To date there have been 157 confirmed + probable cases & 74 confirmed + probable deaths. https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON423
Thiago Carvalho
boosted
#bioinformatics #introduction Hello Tooters! I’m George, I head up bioinformatics at the MRC LMS. Reformed immunologist, retro/virologist, repetitive elements, genomes, *seq, #nextflow. Let’s see what Mastodon can do for us all!
Thiago Carvalho
boosted
The outbreak.info toolset that Dr. Kristian Andersen and collaborators put together to track the SARS-CoV-2 variants has been fixed and all the recent variants now display, so we can see how they diverge: https://outbreak.info/compare-lineages?pango=BA.1&pango=BA.2&pango=BA.2.12.1&pango=BA.2.75&pango=BA.2.75.2&pango=BA.4&pango=BA.4.6&pango=BA.5&pango=BA.5.2.6&pango=BF.7&pango=BQ.1&pango=BQ.1.1&gene=S&gene=ORF1a&gene=ORF1b&gene=ORF3a&gene=E&gene=M&gene=ORF6&gene=ORF7a&gene=ORF7b&gene=ORF8&gene=N&gene=ORF10&threshold=75&nthresh=1&sub=false&dark=false
Thiago Carvalho
boosted
Here's a lil thread of things I *wish* somebody had told me when I started advising #STEM #gradstudents as a lab head, #PhD program director, and grad school conflict-resolution officer. Or maybe they did and I wasn’t listening? 🧵
#gradschool #inclusion #macademia #AcademicMastodon #ScienceMastodon #academia #academics
Thiago Carvalho
boosted
Very cool preprint from Bin Wu's lab.
They found bursting behavior of #translation by #SingleMolecule #mRNA #imaging in live cells, which is modulated by 5'UTR.
@biorxivpreprint
Thiago Carvalho
boosted
This is why I left Twitter and why I don't think Twitter is a safe environment, *especially* for the most vulnerable:
"Everyone here should also know that our CISO, Chief Privacy Officer and Chief Compliance Officer ALL resigned last night. This news will be buried in the return-to-office drama. I believe that is intentional... I do not believe he [Elon] cares about the human rights activists. the dissidents, our users in un-monetizable regions..."
https://www.theverge.com/2022/11/10/23451198/twitter-ftc-elon-musk-lawyer-changes-fine-warning
Thiago Carvalho
boosted
If you are part of the #TwitterMigration you may want to consider downloading your Twitter archive. Even if you’re not deleting your account.
You can’t be sure this possibility won’t suddenly stop working one day.
Instructions for requesting your archive are on the following link. Note that instructions are different for iOS app, Android app and web browser (desktop). You can select an icon for the system you want at the top of the instructions.
https://help.twitter.com/en/managing-your-account/how-to-download-your-twitter-archive
Thiago Carvalho
boosted
RT @YorkBioimaging
Want to lead a leading international microscopy facility? One of the best around!
Head VIB Bioimaging Core - VIB https://jobs.vib.be/j/52537/head-vib-bioimaging-core
"To capture existing knowledge on suppression interactions between human genes, we examined 2,400 published papers for potential interactions identified through either genetic modification of cultured human cells or through association studies in patients. The resulting network encompassed 476 unique suppression interactions that often linked genes that function in the same biological process."
Thiago Carvalho
boosted
Applications are open for the Diverse Voices in Science Journalism Internship - a great opportunity to work at @NewsfromScience for a summer. Please spread the word! bit.ly/3NS2YnX
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Would you like to work with me and my group to investigate #MembraneTraffic in cells? There is a postdoc position available in my lab in Warwick, UK. https://tinyurl.com/roylePostDocJob I'm happy to answer any questions!
#ScienceMastodon #CellBiology #microscopy #PostDoc #vacancy
Pricing of Bavarian Nordic's smallpox/monkeypox vaccine
'The price range for a single dose of the vaccine can be between $70 and more than $300, depending on order size and commercial agreements between the drugmaker and the country buying it, according to a person familiar with the matter.'
https://www.ft.com/content/4b63d5ae-ab71-4db4-85ea-fb67ac633600
Thiago Carvalho
boosted
It's nearing a week now, so I will make this my last "introduction" toot.
Of all the popular science articles I have written, this Nautilus piece -- The Botanist Who Defied Stalin-- is the one I most cherish. It was an HONOR to write about Nikolai VAVILOV.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
