RT @christinerbeck@twitter.com
Celebrate each win. Paper out today is a big one from our lab, examining a mechanism underlying variation between human genomes. We find hundreds of transposon-mediated rearrangements per genome, and can identify them with either @PacBio@twitter.com sequencing-based assembly or short reads
🐦🔗: https://twitter.com/christinerbeck/status/1594748726798843904
'Covid-19 cases in China are spiralling towards record highs, forcing officials to again lock down large swaths of the country.
The world’s second-biggest economy reported nearly 28,000 new Covid cases on Tuesday, with outbreaks in the Chinese capital, the southern manufacturing hub of Guangzhou and the southwestern metropolis of Chongqing continuing to grow.'
https://www.ft.com/content/f724e3ad-8cae-4f00-8ad2-aa8a5c035fe9
A new #SpatialTranscriptomics technique was published on Cell! The authors used polony gels to capture the RNA in situ, and used pixel-seq to map #singlecell transcriptomes back to the tissue. Amazing experimental design! https://www.cell.com/cell/fulltext/S0092-8674(22)01367-8
New #introduction for #twitterMigration.
Hello Mastodon community!
In my lab we work with #stemcells #iPS cells and their differentiation into #neurons and brain #organoids.
We focus on #RareDiseases affecting #mitochondria and energy #metabolism. We develop high-content #microscopy assays for #screening repurposable drugs .
Absolutely fascinating paper by the group of Ed Feil on Klebsiella genomics
https://www.nature.com/articles/s41564-022-01263-0
A large-scale genomic snapshot of Klebsiella spp. isolates (n = 3,482) in Northern Italy reveals limited transmission between clinical and non-clinical settings
Relevant quote from abstract
"Although we noted occasional transmission between clinical and non-clinical settings, our data point to a limited role of animal and environmental reservoirs in the human acquisition of Klebsiella spp."
RT @LauCan88
📢 Two postdoc positions in Machine Learning for single-cell genomics open in my team @IBENS_ENS, @InstitutPrairie and soon @institutpasteur
in collaboration with @gabrielpeyre @ENS_ULM
PM me if interested
RT please🙏!
"In memory T cells, the frequency of CXCR5+CXCR3+CCR6− circulating follicular Th1 was positively correlated with RBD-specific Ab-secreting B cells. For the response to variant RBDs, although 60–80% of memory B cells could bind to the omicron RBD, their avidity was low, whereas memory T cells show an equal response to the omicron spike."
"The human MPYS gene is highly heterogeneous (9, 10). Approximately 50% of Americans carry a non–wild-type (WT) (R232) MPYS allele (9). R71H-G230A-R293Q (HAQ) is the second most common human MPYS allele carried by ∼25% of Americans and ∼63% of East Asians (EAS) (9). Surprisingly, we recently found that HAQ knock-in mice do not respond to CDNs in vivo (11). In corroboration, Mogensen and colleagues (12) reported that homozygous HAQ MPYS/STING was enriched in HIV-infected individuals that were long-term nonprogressors."
Hi #introduction from me..!
I'm a Prof of Operational Research at UCL & member of Independent SAGE.
As such, I've been tweeting about Covid for 2.5 yrs now so expect more of that here!
Plus occasional forays into politics, women in science, general science & stuff about London.
Hope I get the hang of it soon!
‘Eat local’ is a common recommendation to reduce the carbon footprint of your diet.
But transportation makes up a very small amount of the greenhouse gas emissions from food.
*What* you eat is far more important than *where* your food traveled from.
The distribution map of the hoverfly Eristalis pertinax may be telling a story about failed clean water regulations:
“Eristalis pertinax is a European hoverfly. Like Eristalis tenax, the larva of E. pertinax is a rat-tailed maggot and lives in drainage ditches, pools around manure piles, sewage, and similar places containing water badly polluted with organic matter.” https://www.inaturalist.org/taxa/52490?locale=en-GB
Caveats: sampling bias, and unknown distribution prior to modern waterways pollution.
Scientists! Many of my fellow reporters at @sciencemagazine are here now:
Ace pandemic reporters @kakape and @joncohen;
@rpocisv, covering diversity in science;
@boron110, our delightful podcast host;
@martinenserink, international editor and public health guru;
@klangin, covering the scientific workforce;
@DanClery, covering astronomy;
@lguterman, editing chem and bio;
@cathleenogrady, writing about science and society;
@meredithwadman@newsie.social, covering medicine and bad behavior.
Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.
We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.
Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown
#introduction. I am a plant developmental geneticist. The lab addresses a fundamental biological question: how does morphogenesis translate genotype into form? To this end we study signaling at the plasma membrane - cell wall interface and we investigate how mechanical forces influence tissue shape using 3D digital ovules.
Main interests:
#Arabidopsis #cellbiology #cellbio #cellwall #devbio #devbiol #DevelopmentalBiology #evodevo #imaging #mechanobiology #microscopy #plantbiology
Time for my #neuroscience #introduction here. I am studying the nervous systems of jellyfish using computational modelling, trying to understand their dynamics and their evolution. I use biophysical neuron models and feed the resulting dynamics of their network into fluid dynamics simulations to study how their neuronal dynamics control the swimming and turning of these strange creatures.
'Drug resistance is a known risk factor for poor tuberculosis (TB) treatment outcomes, but the contribution of other bacterial factors to poor outcomes in drug susceptible TB is less understood. Here, we generate a population-based dataset of drug-susceptible Mycobacterium tuberculosis (MTB) isolates from China to identify factors associated with poor treatment outcomes.'
https://www.biorxiv.org/content/10.1101/2022.11.20.517261v1?med=mas
'Verified accounts are frequently seen as reliable and trustworthy, and Twitter’s algorithm gives them a higher ranking in search results, replies and follow recommendations.
“There’s a sense of legitimacy that comes with it,” said Barry. “By verifying this anti-vaccine account, they’re kind of verifying all of the misinformation it shares … it makes people think, ‘Oh, well, this is a verified account. This must be true.’”
" Management of the SVD outbreak in Uganda in 2000 was complicated by the fact that the outbreak-response team did not understand the local health beliefs and missed an opportunity to align their risk communication with the population’s understanding of disease transmission.5 This hard-won lesson has led to the regular inclusion of anthropologists in response teams to aid in designing and implementing control measures."
#Virology #Epidemiology #Filovirus #NEJM
https://www.nejm.org/doi/full/10.1056/NEJMp2213975?query=featured_home
Fighting health misinformation on social media has been hard enough these last ~3 years, but will be almost impossible now that "[Twitter's] paid verification system is being used to give sense of validity to accounts pushing health misinformation."
An important read from @m_scribe at https://www.theguardian.com/technology/2022/nov/21/twitter-anti-vax-health-misinformation?CMP=Share_iOSApp_Other
Or maybe you could just pay them properly?
RT @Smyth_Chris@twitter.com
Sunak repeatedly says the NHS must be more innovative and "radically" change how it cares for patients
"We need to be bold and radical in challenging conventional wisdom," he says. Examples include "thinking creatively" about what doctors, nurses and other staff actually do
🐦🔗: https://twitter.com/Smyth_Chris/status/1594645666847940609
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com