Time for my #introduction ! I’m an Assistant Professor at the Institute of Microbiology and Infection, University of Birmingham. Me and my team study #AMR in G-ves, mostly E. Coli & #Klebsiella. We look at plasmid mediated AMR such as #ESBLs and carbapenamases, understanding their fundamental biology and looking at how we can stop them! Still learning this platform!
Hello #sciencemastodon - we'll be posting our news and updates here and on our Twitter account (@AnnualReviews).
Not good news on the clinically available monoclonals vs newer covid lineages.
"Our data reveal that emerging omicron sublineages are resistant to most (ie, BA.4.6, BA.2.75.2, and BJ.1) or all (BQ.1.1) clinically used mAbs. As a consequence, in patients at high risk, treatment with mAbs alone might not provide a therapeutic benefit in regions of the globe in which BQ.1.1 is spreading, suggesting that additional treatment options (eg, paxlovid or molnupiravir) should be considered. Furthermore, novel, broadly active mAbs are urgently needed for prophylactic or therapeutic treatment, or both, in patients at high risk."
#COVID #Antibody #MonoclonalAntibody
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00733-2/fulltext
🇫🇷 French media regulator asked Twitter to explain how it will respect the law on hate speech and misinformation now that most of its moderators are gone. Twitter has until Thursday to answer.
RT @florianjug@twitter.com
🚨Job Alert 🚨
We are looking for a #BioimageAnalyst and/or #RSE to join our growing image analysis facility here at Human Technopole in the beautiful city of Milan, Italy.
#Apply before December 16!
https://forum.image.sc/t/job-opportunity-bioimage-analyst-and-research-software-engineer/74182
🐦🔗: https://twitter.com/florianjug/status/1594720930907185152
#Introduction: I'm a Research Fellow at NCI/NIH and AMNH studying #VirusEvolution.
My main project investigates #HPV and #CervicalCancer.
Other scientific interests include #MolecularEvolution, #PopulationGenetics, #mutation, #SARSCoV2, #OverlappingGenes, and #bioinformatics methods.
When I'm not coding I'm #weightlifting, #reading, #singing, or drinking #coffee.
So excited to be part of this community!
Beautiful #cryoET paper on choanoflagellate #flagella #cilia revealing the enigmatic ciliary vane, new components and similarities to animal cilia
#protist #evolution #EM #choanoflagellate
https://elifesciences.org/articles/78133
"Living with viruses should mean embracing simple public health measures rather than learning to live with staggering levels of illness and death. "
https://qoto.org/@cyrilpedia/109387587607038029
"Untangling such interference hasn’t been easy given the number of respiratory viruses—coronaviruses, rhinoviruses, adenoviruses, RSV, and influenza are just among the best known—and the many infections that escape notice. Recent advances in technology, however, make it easier to detect infections in people and study how multiple viruses behave in the lab, in cell cultures or stem cell–derived tissues known as organoids. Increasingly, researchers are fingering a cause: chemical messengers that infected people produce called, fittingly, interferons."
"A storm of these proportions should demand not only crisis clinical measures, but also community prevention efforts. Yet instead of deploying public health strategies to weather the storm, the U.S. is abandoning them."
#Flu #RSV #Covid #publichealth
https://www.statnews.com/2022/11/22/tripledemic-hurricane-include-community-prevention-efforts/
Haaretz editorial: A Convicted Criminal as Israel’s Super Police Chief
“…not just a blow against the separation of powers but a serious danger to the rights of Israel’s Arab citizens….the fact that it will be in the hands of a pyromaniac like Ben-Gvir only magnifies the danger.”
That's embarrassing. Marcel Levi, the president of Dutch science funding agency NWO, wrote a newspaper column ridiculing the concept of social safety at work as a "meaningless buzzword" and said people use it just to get a new desk chair or a faster computer.
The Dutch academic community, still reeling from a major misbehavior case, was aghast; five days later, Levi was upbraided by his own Executive Board and apologized profusely. https://www.nwo.nl/en/news/marcel-levi-social-safety-paramount-importance-academia
Huge study showing 62% more likely chance of developing diabetes after #Covid_19 (compared to if you don’t get covid), especially in the first 3 months. Even in kids! #WearAMask
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02656-y
RT @NatureCancer@twitter.com
HOT OFF THE PRESS 🔥- “Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect” by @SageJulien@twitter.com #EdwardEGraves #YokoNishiga & Co. #immunotherapy
Read it here 👇👇
https://www.nature.com/articles/s43018-022-00456-0
https://rdcu.be/c0a8o
🐦🔗: https://twitter.com/NatureCancer/status/1595031172698222594
Cool paper
Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation
I didn’t realize that the Dutch fought for their bike lanes. There’s a lot of history within this that I’m currently naive about but excited to learn!
Here’s the article I’m starting with — How the Dutch got Their Cycle Paths: https://www.pps.org/article/how-the-dutch-got-their-cycle-paths
"The situation at Cambridge worsened for Bateson as he began expanding his research group. Bateson was sympathetic to the women’s suffrage movement in which his mother Anna Aitkin and sisters Margaret, Anna, and Mary Bateson were prominently involved (Box 1). He welcomed women into his laboratory group. Some of the first papers from his group were coauthored by his sister Anna who also worked with Francis Darwin (botanist and son of Charles Darwin) during her studies at Cambridge. However, Sedgwick strongly disapproved of women in the academy, and this principled position cost Bateson throughout his career. Though he was employed at Cambridge for the entirety of his career, his promotion was overlooked for more than a decade. Nevertheless, his integrity remained intact and his collaborations with many female scientists including Edith Saunders, later referred to as the “mother of British plant genetics” [23], were incredibly productive (Box 2)."
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010379
Some really great #DevBiol #CellBio UK names on the latest @ERC_Research list of 2022- CONGRATULATIONS all! https://erc.europa.eu/sites/default/files/document/file/erc_2021_stg_results_ls.pdf
Even better now we finally have some clarity on UK Horizon commitments to those currently caught up in the uncertainty- : https://questions-statements.parliament.uk/written-statements/detail/2022-11-21/hcws376
On Dec. 1-2, @HHMINEWS, @EMBO, and @ASAPbio_
will host a meeting on #RecognizingPreprintReview.
They are collecting feedback on how researchers, funders, & editors might participate in preprint review.
To share your views, fill out their survey at https://tinyurl.com/87f23jk5
For more on how to make journal and preprint more complementary, see also
https://osf.io/t65a2/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com