Thiago Carvalho @cyrilpedia@social.cleverlibre.org

“A theme of the novel,” le Carré wrote to his aunt Ella Haymes, who along with her sister Ruby was upset by the book (or at least its reception—they hadn’t read it), “is that hypocrisy thrives upon the silence and the goodheartedness of respectable people, and that deceit, when it passes unchallenged, can be bestowed upon one generation by another.”

https://www.bookforum.com/print/2904/the-correspondence-of-spy-turned-novelist-john-le-carre-25148

"Preprint #Immunology #HumanGenetics #PrimaryImmuneDeficiency #NFKB

'We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to multiple pathogens including those from the herpes, retro- and polyoma-virus families.'

https://www.medrxiv.org/content/10.1101/2022.11.24.22282707v1

Model organism limitations

"Although many of the fundamental observations in murine models are expected to be similar in human tissue, it may still be difficult to directly transfer the observations to a human context. In particular, murine skin architecture is dominated by hair follicles, which are less frequent in human skin, leaving human skin with a larger proportion of much thicker interfollicular epidermis (22). Hence, to understand and translate the functions of the TGF-β signaling pathways into a human setting, it is important to use a human cellular and tissue system"

https://www.science.org/doi/10.1126/scisignal.abo2206

"Many researchers do not share their data and code simply because they do not know how. The process of archiving data and code is not always straightforward. In one survey of biologists, 46% of respondents were unaware of how to organize data in a presentable and usable way, and 33% reported that not knowing which online hosting service, or repository, to use was a barrier to sharing data and code "

https://royalsocietypublishing.org/doi/10.1098/rspb.2022.1113

Atlas

"Ulcerative colitis (UC) and Crohns disease (CD) are chronic inflammatory intestinal diseases that show a perplexing heterogeneity in manifestations and response to treatment. The molecular basis for this heterogeneity remains uncharacterized. We applied single-cell RNA sequencing and CosMxTM Spatial Molecular Imaging to human colon and found the highest diversity in cellular composition in the myeloid compartment of UC and CD patients."

#IBD #Preprint #UlcerativeColitis #CrohnsDisease #Immunology #MucosalImmunology

https://www.biorxiv.org/content/10.1101/2022.11.28.518139v1

'After the Nazis invaded France in May 1940, he fled Paris by bicycle, with Pontecorvo and others. Regrettably, Selya provides only a brief sketch of this dramatic escape to the south of France, through Spain to Portugal, where he was finally granted US immigration papers. She notes that the drama included being shot at from planes and hiding in an abandoned farmhouse with the Italian writer Carlo Levi. From Lisbon, Luria travelled in a ship packed with refugees, reaching New York City on 12 September, with US$52 in his pocket.'

https://www.nature.com/articles/d41586-022-04153-x

'Some scientists' have a point:

"Some scientists have expressed caution about reading too much into topline results, which show lecanemab reduced the rate of cognitive decline in early-stage patients by 27 per cent compared with a placebo after 18 months. They said it was critical that Eisai and Biogen present full trial data and publish their findings in a peer-reviewed journal to rebuild confidence in amyloid-targeting #Alzheimer’s drugs following recent failures."

https://www.ft.com/content/bbb2e44a-af10-4926-b97b-3a26947bcb2e

Tom Stoppard on his new play, Leopoldstadt

“In a scene that takes place in 1955,” says the great playwright, perhaps our greatest, now 85 years old, “the young Englishman says to the Jewish man, ‘It can’t happen again.’ It’s almost a foolish remark now. Whereas when the play was being written, I didn’t think of it as being a foolish remark.”

https://www.nytimes.com/interactive/2022/11/28/magazine/tom-stoppard-interview.html