Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Oh this is too good. Since Twitter is now blocking Mastodon links, someone has created a link shortener to hide them. Gotta love the URL:

https://spacekaren.sucks/

Does anyone know a published example where #AlphaFold was used to predict where insertion of a tag could be well tolerated? I wrote that this is preferred now (vs trial-and-error) and have been asked to add a citation. Struggling to find a paper that explicitly says construct was designed this way.

#CellBiology #StructuralBiology

Allow #myself to #introduction #myself.

I am a #basic neuroscientist and Associate Professor at the University of Washington, where my lab studies how the brain senses and moves the body (#proprioception #motorcontrol).

I will mainly be tooting about the #research and accomplishments of the scientists in my lab, new and old #neuroscience papers that incite me, and efforts to improve the rigor and equity of science. I may slip in the occasional #snowfly pic.

I hope to use #ScienceMastodon for discovering new scientific #manna and for unexpected interactions with #Scientists and #PseudoScientists alike.

I'm thrilled to post a special podcast episode, a story I reported across continents about moves to make vaccines in the global south.

It's a move that could make the world safer for all of us.

Please give it a listen
Apple: https://podcasts.apple.com/us/podcast/vaccine-inequity/id73329638?i=1000586910937

Stitcher: https://www.stitcher.com/show/big-picture-science/episode/vaccine-inequity-208766398

Spotify: https://open.spotify.com/episode/5rxmjbqywSe12sd47LdCdb

Excited to share this new work from my postdoc with @lindymcbr, just out in The American Naturalist.

We found a BIG shift in the behavior of Aedes aegypti mosquito larvae that may help them use novel breeding sites in human settlements, i.e., anthropogenic evolution. 1/20

https://doi.org/10.1086/722481

Check out this job at AbCellera: Head of Functional Biology (Immunology/Oncology) https://www.linkedin.com/jobs/view/3368564692

I’m super excited that part of my PhD thesis got published today.

Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding. https://doi.org/10.1126/sciadv.ade7209

We show that olfactory sensory neurons undergo silencing due to depolarization block at ethologically relevant odor concentrations, which has direct implications on how odors are represented at the sensory periphery.
#neuroscience #olfaction #olfactory transduction #electrophysiology #behavior

1/

A quick #introduction. I shifted here from #Twitter a few weeks back and will continue to jump back and forth until the foot no longer lands in the other spot. Anyway, I am a neuroscientist who uses #neuroimaging, #ComputationalModeling, to build brain theories of resilience and adaptation. I'm also an amateur #musician with a small but mighty band in #PortMoody. I'm also an avid #runner, so that I can sample the wide array of #craftbeer out here. #toot on y'all.

@cyrilpedia There's a good Atlas Obscura article about this too! In the japanese Navy, each ship has a specific version of the curry https://www.atlasobscura.com/articles/japanese-curry-history

The field of immunology has lost a giant in Emil Unanue. To the surprise of no one who knew him, he fought off glioblastoma for far longer than the prognosis would suggest. He won the Lasker prize in 1995 for his work on antigen processing that forms the basis of our textbooks. He didn't offer praise often or lightly, but when he did, boy it felt good. This simple email to me after a seminar lifted my spirits for weeks! We will miss him.

Alexandra Petri is a national treasure.
“There are so many people who are interesting. And instead we have to follow Elon Musk and Donald Trump.., because their whims can cost people jobs and ruin lives.
There is something desperately boring about despots and plutocrats. And one of the frustrating consequences of an unequal society is that the rest of us have to care what is going on with them.”
https://www.washingtonpost.com/opinions/2022/12/17/elon-musk-twitter-overkill/

An interesting historical perspective on Anglo-Indian cuisine and the concept of "curry" https://www.atlasobscura.com/articles/curry-in-colonial-india

New instance, new #introduction! I'm a PhD student at UMich studying how we make sense of sound. I use patch-clamp #electrophysiology in #brain slices and awake mouse brains, where I investigate everything from receptors on individual #neurons to population level encoding of complex #sounds. I want to make science more diverse, accessible, and impactful for everyone. 👂​🔈​🧠​🔬​

Since I moved to a new server an #introduction

I am the director of Spinoza Centre for Neuroimaging (@spinoza), group leader at the Netherlands Institute for Neuroscience and professor at Utrecht University and Vrije University Amsterdam.

My research is centered on the intersection of #perception, #cognition and #neuroscience. The ultimate goals are to understand the neurophysiology of the visual system, and how neural computations result in visual perception and cognition. My research reconstructs perceptual representations of the human brain using #behaviour, #computational models, #neuroimaging (predominantly 7T fMRI), and custom-built biologically-inspired data-analysis methods (for example the pRF method).

I'm enjoying #mastodon and exited to see it grow so quickly!

I want to tell you the story of Vivienne Malone-Mayes, Texas-born mathemetician and professor, but I don't think you can understand her journey without talking about the #AcademicRacism in which she existed.

Always worth listening to @tzimmer_history, @LilyMasonPhD and @perrybacon. However, this episode "We Need to Talk About Centrism," is fantastic. As Paul Farmer once said “WL’s [White Liberals] think all the world’s problems can be fixed without any cost to themselves," but now the bill is coming due, they are being asked to pay up just a little. WLs don't like it and are turning rightwards looking for safety, turning into "reactionary centrists."

https://anchor.fm/is-this-democracy/episodes/7--We-Need-to-Talk-About-Centrism-e1sb456

Immediately after I posted this I was followed by @scstroupe who (a) solved the crystal structure of the yeast homolog of Rab3A, and (b) taught me how to use an FPLC.

Yes, I think Mastodon is going to be an OK place to hang out.

A bit of cell biology history. I was going through a box of inherited column hardware and found this, which would have been used in the Glomset lab as they were discovering and characterizing prenylation of Rab GTPases in the early 1990s.