Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'We demonstrated that G protein combined with CSA not only induced a high level of neutralizing anti-RSV Abs that led to reduced viral titers, but it also suppressed the lung inflammation that causes the severe lung injury often seen with FI-RSV vaccination. The suppression was due to induction of Treg cells.'

#immunology

https://journals.aai.org/jimmunol/article/196/4/1721/43258/A-Recombinant-G-Protein-Plus-Cyclosporine-A-Based

"When members are sworn in, they take an oath to support their local product. Often, they don headgear, medallions, and long robes whose colors and cuts reflect their beloved comestible. That can mean outfits that honor unique specialties such as pink garlic, or blue leeks."

https://www.atlasobscura.com/articles/french-food-brotherhoods

'Across the city’s working-class districts, women and men established vigilance committees and joined (or re-joined) the National Guard to help defend the revolution. They formed political clubs, expressing their concerns and demands, and associations to reform or revolutionise education, women’s labour, the arts. Uncertain of what lay ahead, these emergent Communards began creating the world they wanted. The popular clubs and associations enacted direct democracy: a third power centre.'

https://aeon.co/essays/how-to-make-a-revolution-the-1871-paris-commune

Lisbon

"To explore the feasibility of eliciting CD4+ T cell responses widely cross-recognizing different CoVs, we utilized samples collected pre-pandemic to systematically analyze T cell reactivity against representative alpha (NL63) and beta (OC43) common cold CoVs (CCC)."

#immunology #Coronavirus #Vaccines #Preprint

https://www.biorxiv.org/content/10.1101/2023.01.04.522794v1

'
The Natural History Museum has been denounced for signing a gagging order which prevented it from criticising a Danish oil company that sponsored its wildlife photography competition.

The clause was put into a contract with Dong Energy, now known as Orsted, for its sponsorship of the Wildlife Photographer of the Year competition.'

https://www.theguardian.com/culture/2023/jan/08/natural-history-museum-gagging-order-danish-oil-sponsor

"However, isolation of ‘TCR-mimic’ (TCRm) Abs is laborious because Abs have not evolved the structurally nuanced peptide–MHC restriction of αβ-TCRs. Here, we present a strategy for rapid isolation of highly peptide-specific and ‘MHC-restricted’ Abs by re-engineering preselected Abs that engage peptide–MHC in a manner structurally similar to that of conventional αβ-TCRs."

https://www.nature.com/articles/s41587-022-01567-w

"But in some residential neighbourhoods where the NEA and Verily have run field trials, it is a different story. Verily’s tech fights dengue-carrying Aedes aegypti mosquitoes with the release of other facility-bred Wolbachia-Aedes mosquitoes. The NEA has reported up to 98 per cent suppression of the Aedes aegypti population and an 88 per cent reduction in dengue cases after at least one year of releases under Project #Wolbachia, which Verily joined in 2018."

#Dengue
https://www.ft.com/content/9ee5a38f-9f5e-4434-89ec-309f6d2513ca

'In her shattered Philadelphia neighborhood, and increasingly in drug hot zones around the country, an animal tranquilizer called xylazine — known by street names like “tranq,” “tranq dope” and “zombie drug” — is being used to bulk up illicit fentanyl, making its impact even more devastating.'

https://www.nytimes.com/2023/01/07/health/fentanyl-xylazine-drug.html