Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Chaotic is how I’d describe my childhood. My parents shuffled between the US and Korea. I had a tapeworm at one point. My American doctor, who had never seen one, asked to keep it. I wonder where it is – and if my name is on it."
"There is one obvious way in which human neurons and their dendrites are different from dendrites in, say, cats or rats: they are bigger. However, are these anatomical differences, which alone could change the signal processing capabilities of dendrites [2.,3.], also accompanied by differences in functional properties?"
https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(20)30069-3
Thiago Carvalho
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"Q: What is your idea of perfect happiness?
A: Reading."
David Bowie, born on this day in 1947, answers the famous Proust Questionnaire https://www.themarginalian.org/2014/07/10/david-bowie-proust-questionnaire-vanity-fair/
Thiago Carvalho
boosted
RT @sohailtavazoie
How does Codon bias emerge? @DennisJHsu shows: limiting arginine causes arginine codon switching mutations in cancer: Low Arg aa-> reduced Arg tRNA->ribosome pausing->proteomic shift->DNA evolution. big thx to @s_tavazoie @Columbia @Rockefeller https://www.science.org/doi/10.1126/sciadv.ade9120
Thiago Carvalho
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Identification of astrocyte regulators by nucleic acid cytometry
Thiago Carvalho
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RT @LChittka
PhD opportunity in my team: https://www.findaphd.com/phds/project/insect-visual-cognition-and-neural-computation/?p150912
Thiago Carvalho
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I'm looking through some of our recent data using a glowing (luciferace) #Borrelia bacteria (which causes #Lyme disease) and noticing that often the infection spreads to the right foot before the left (look carefully at the right feet in day 14 image on the right). Their right ankles consistently also swell much more than their left ankles in this #infection model. So I'm puzzling over this and if there's a contribution of handedness in infection outcomes. Any thoughts?
Thiago Carvalho
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In pictures: Europe's snowless ski resorts
Experts say this season's lack of snow offers a glimpse of the future, as global temperatures climb ever higher due to human-induced climate change
https://www.euronews.com/2023/01/07/in-pictures-europes-snowless-ski-resorts
#ClimateChange #skiing #GlobalWarming #ClimateEmergency #CO2 #photos #snow #Alps
Thiago Carvalho
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Elon Musk reinstates TRAITOR Michael Flynn’s acct ON JANUARY 6TH?
Thanks Elon for affirming why I killed a 125k Twitter acct.
FUCKING TRAITOR PIECES OF SHIT.
"Most relapsed/refractory large B cell lymphoma (r/rLBCL) patients receiving anti-CD19 chimeric antigen receptor (CAR19) T cells relapse. To characterize determinants of resistance, we profiled over 700 longitudinal specimens from two independent cohorts"
#CART #immunotherapy #immunology #Lymphoma #LBCL #CD19
https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00591-8?dgcid=raven_jbs_aip_email
Thiago Carvalho
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Sensor #NLR #immune proteins activate #oligomerization of their NRC helpers in response to #plantpathogens
Kamoun and cowokers, The Sainsbury Lab
https://www.embopress.org/doi/full/10.15252/embj.2022111519
Tools
"Here, we describe the development and validation of a computational program, which designs strain-specific CRISPR guide RNAs that can be utilized to modify complex consortia. As a proof of concept, we applied the program to two applications: the isolation of specific microbes from consortia and the removal of specific microbes from consortia. This technique has many practical applications, including addressing the problem of antibiotic-resistant microbes and isolating useful microbes from the environment."
#CRISPR #Microbiology
"Her first stint as minister was widely hailed as a success, with Marina reducing Amazonian deforestation by as much as 70 per cent. Her administrative and financial initiatives included new management of public forests, the creation of a forest service and a biodiversity institute and several funds for the maintenance of the Amazon."
https://www.ft.com/content/53641c63-f90a-4171-902d-bf07398918d8
Kudos to Pam Belluck at the NYT for this opening paragraph - this is the right way to report on a story like lecanemab:
"The Food and Drug Administration on Friday approved a new #Alzheimer’s drug that may modestly slow the pace of cognitive decline early in the disease, but also carries risks of swelling and bleeding in the brain."
https://www.nytimes.com/2023/01/06/health/alzheimers-drug-leqembi-lecanemab.html
Thiago Carvalho
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Resurrection of endogenous retroviruses during aging reinforces senescence
Thiago Carvalho
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How to slow down scientific progress
"Leo Szilard—the physicist who first conceived of the nuclear chain reaction and who urged the US to undertake the Manhattan Project—also wrote fiction. His book of short stories, The Voice of the Dolphins, contains a story “The Mark Gable Foundation,” dated 1948."
You can see the full thing at this link, but I've also taken a screenshot of an excerpt. 😬 🤔 😢
Thiago Carvalho
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RT @aetarke@twitter.com
Can CD4+ T cells cross-recognize different coronaviruses (CoV), offering immune protection from potential future CoV pandemics? We explore this concept in our new study, just posted in pre-print. http://biorxiv.org/content/10.1101/2023.01.04.522794v1
@Alba_Grifoni@twitter.com @SetteLab@twitter.com 1/5
Thiago Carvalho
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RT @feleszko@twitter.com
A good and robust guidance through management and #immunology of #pediatric MIS-C/PIMS by the #EAACI Immunology Section with @dekinderarts@twitter.com. https://onlinelibrary.wiley.com/doi/10.1111/pai.13900
Thiago Carvalho
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Computational design of #CRISPR guide RNAs to enable strain-specific control of #microbial #consortia | PNAS
Thiago Carvalho
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Last month I gave the keynote address at the Seattle Data for Policy meeting, entitled "Social media, Collective Decision-making, and the Stewardship of Global Information Flows"
It's now puiblicly available on youtube: https://www.youtube.com/watch?v=oATpDGdrTLg
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
