Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Depleting nutrients by dilution of culture medium caused parasites to produce less merozoites and reduced proliferation but did not affect cell volume or total nuclear volume at the end of schizogony. Our findings suggest that malaria parasites use a resource-dependent counter mechanism to optimize their progeny number during blood stage infection."

#Preprint #Malaria #Plasmodium

https://www.biorxiv.org/content/10.1101/2023.01.20.524890v1?med=mas

"Our findings suggest a previously unappreciated role for ALT in telomere maintenance in telomerase-positive iPSCs and reveal distinct iPSC-specific responses to targeted telomeric damage."

#Telomeres #Preprint

https://www.biorxiv.org/content/10.1101/2023.01.19.524780v1?med=mas

An illustration that Madalena Parreira made for an interview I did with Leonard Zon for the now defunct JEM blog "Dr Flexner's Suitcase".
https://madalenaparreira.com

"You’re never more than 6ft away from a rat in a big city, according to the adage. Now, the world’s biggest pest control group is planning to annihilate the pesky rodents by using facial recognition to track their habits."

https://www.ft.com/content/641036f1-acbb-409b-9b78-e63c04bdf4e7

"Hematopoietic stem cell (HSC) transplantation (HSCT), also known as bone marrow transplantation, was established as an effective treatment for SCID by the 1980s. However, without a family history or an astute clinician familiar with this rare disease, infants frequently died prior to diagnosis and transplantation."

https://journals.aai.org/jimmunol/article-abstract/210/3/219/237664/Early-Is-the-Key-for-Treatment-of-Severe-Combined?redirectedFrom=fulltext

'Entre Kabul y São Paulo hay nada menos que 13.700 kilómetros, dos continentes y un océano. La lógica no invita a pensar que Brasil fuera a convertirse en el país de acogida favorito para los afganos que huyen del régimen talibán, pero el paisaje de la terminal 2 del aeropuerto internacional de São Paulo es bastante elocuente: entre improvisados colchones y tiendas de campaña viven decenas de afganos que desde hace meses llegan a Brasil a cuentagotas.'

https://elpais.com/internacional/2023-01-21/brasil-la-inesperada-ultima-esperanza-de-los-refugiados-afganos.html

Perish the thought

"Elmendorf, an economist who served as director of the Congressional Budget Office from 2009 to 2015, also pushed back against the charge that donors had influenced his initial decision, which was suggested in the Nation article and reiterated in public statements by Roth."

https://www.nytimes.com/2023/01/19/arts/harvard-israel-antisemitism-roth.html

'At least five of the winning models demonstrated accuracy exceeding 90% at detecting lung nodules. But to be clinically useful, those algorithms would have to perform equally well on multiple data sets.

To test that, Kun-Hsing Yu, a data scientist at Harvard Medical School in Boston, Massachusetts, acquired the ten best-performing algorithms and challenged them on a subset of the data used in the original competition. On these data, the algorithms topped out at 60–70% accuracy, Yu says. In some cases, they were effectively coin tosses'

https://www.nature.com/articles/d41586-023-00023-2?utm_source=linkedin&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO