Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'A sua imagem política está mais do que consolidada. E a fasquia está altíssima. Não é fácil bater a beleza de meter banqueiros na ordem. Grande desafio para o partido e para a futura coordenadora.'

https://www.publico.pt/2023/03/01/opiniao/opiniao/mariana-mortagua-beleza-lutar-vida-boa-2040650

Enter the Red Queen.

"Eric Mitchell, a graduate student at Stanford University, figured a classifier would take a lot of training data. Along with colleagues, he came up with DetectGPT, a “zero-shot” approach to spotting the difference, meaning the method requires no prior learning. Instead, the method turns a chatbot on itself, to sniff out its own output."

https://www.ft.com/content/e34c24f6-1159-4b88-8d92-a4bda685a73c

Last fall I spoke with @MarkHanson, who was then in Bruno Lemaitre's lab, for EMBO's @ReviewCommons platform for refereed #preprints. I love this detail about how flies grow - I picture a tiny little bicycle pump in there somewhere:

'When flies eclode from the pupa they are soft and squishy and they “manually” inflate their wings by pumping air through their body and that inflates the cuticle in a way that there is room for the body to move around inside that shell.'
#Drosophila #InnateImmunity

https://www.reviewcommons.org/blog/models-oddballs-and-preprints-a-conversation-with-mark-hanson/

PNAS outlines its policy for the use of text generated by ChatGPT et al in papers. Not clear what the process will be if the AI is an Academy Member.

https://www.pnas.org/post/update/pnas-policy-for-chatgpt-generative-ai

'Here, we show that in a mouse model of MS, T cell-specific Ahrknockout leads to recovery driven by a decrease in T cell fitness. At the mechanistic level, we demonstrate that the absence of AHR changes the gut microenvironment composition to generate metabolites that impact T cell viability, such as bile salts and short chain fatty acids.'

#Immunology #MucosalImmunology

Merchak et al @PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002000

Multiculturalism in Pamplona.

"One of the fundamental questions in biology is how the vast diversity of morphologies in organisms is generated. Today, it is well-accepted that similar genes fulfil similar functions in different organisms. However, more than 40 years ago it was still assumed that morphological differences between animals were controlled by very different genes."

https://www.nature.com/articles/s41580-023-00592-0

This is accurate

"Italo Calvino was, word for word, the most charming writer to put pen to paper in the twentieth century."

https://www.newyorker.com/magazine/2023/03/06/the-worlds-of-italo-calvino

ICYMI, it was a pleasure to interview Nobel-prize winning immunologist Tasuku Honjo about the story behind his lab's discovery of PD1, a classic @embojournal paper from 1992.
🎧 #EMBOPodcast #EMBOJournal #Immunology #immunotherapy #checkpointinhibitors #HistoryOfScience

https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/