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ICYMI: Read about @Dev_journal new partnership with @WoodlandTrust

For every article published a #nativetree is planted in a UK forest

For every peer review, we support the restoration & preservation of #ancientwoodland
journals.biologists.com/dev/ar

"More and more scientists are realizing that animals, like people, are individuals: They have distinct tendencies, habits, and life experiences that may affect how they perform in an experiment. That means, some researchers argue, that much published research on animal behavior may be biased."

theatlantic.com/science/archiv

We are looking for a new PhD student to study experience-dependent modulation of olfactory circuits in the fly brain. See details here: jobs.ice.mpg.de/jobposting/d63
Please spread the word! Thanks!
#drosophila #neuroscience #phdPosition

Just so we’re clear here, Florida wants to ban children from discussing their periods but also wants student athletes to report their periods, in case you were still unclear about how fucking dumb these people are.

NEW ARTICLE: Ten Essential Classic International Films You Can Watch for Free on YouTube, Part 1

A curated collection of ten masterpieces of world cinema available for free to watch and study on YouTube.

Read here: medium.com/fan-fare/ten-essent

#film #movies #cinema #internationalcinema #WorldCinema #classicfilm #classicmovies #foreignfilm

From Michael Gale's lab, a small molecule RIG-I agonist

"We have now determined direct binding of KIN1148 to RIG-I to drive expression of IFN regulatory factor 3 and NF-κB target genes, including specific immunomodulatory cytokines and chemokines. Intriguingly, KIN1148 does not lead to ATPase activity or compete with ATP for binding but activates RIG-I to induce antiviral gene expression programs distinct from type I IFN treatment"

journals.aai.org/jimmunol/arti

'We think of him painting the beautiful: Ginevra de’ Benci, Cecilia Gallerani and Salai glow with glossy hair and good bone structure. Yet alongside his fascination with youth and loveliness Leonardo was obsessed with irregular, diseased and aged faces whose “monstrous” distortions he drew with daunting precision.'

theguardian.com/artanddesign/2

RT @IdoAmitLab
Very impressive work, with potential to deepen our understanding of cell-cell communications.
biorxiv.org/content/10.1101/20

'In a study published by the American Cancer Society in March, researchers estimated that in 2023, 153,000 people in the United States would be diagnosed with colorectal cancer. Of those cases, about 13 percent would be among people under 50 — representing a 9 percent increase in cases in this age group since 2020.'

nytimes.com/2023/03/20/well/co

RT @wolfgangkhuber
Postdoc position in spatial and single-cell computational biology for precision oncology at EMBL

Contribute your skills in data science, statistics, ML to an application of latest technologies to a large clinical collaboration on exciting new drug class

embl.org/jobs/position/HD02326

Mitochondrial damage activates the NLRP10 inflammasome
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RT @IIIBonn
We are super excited to share the newest publication from the Latz Lab @IIIBonn in @NatImmunol 🔥🎉

nature.com/articles/s41590-023

A great collaboration with Franklin Zhong and @FISchmidtLab

Summary below, from twitterless 1st author Tom... 1/n
twitter.com/IIIBonn/status/163

The Harlem Hellfighters were a predominantly Black regiment in WWI. They confronted racism even as they trained for war, brought jazz to France, and battled longer than any other American unit. They also won the Croix de Guerre for their bravery. The medals can be seen in the colourized photo.

In my latest Clinical Pipeline column for Nature Medicine, a look at iPSC therapy for heart failure.

"Heartseed is not the only company currently performing clinical trials with iPSC-derived cardiomyocytes. Help Therapeutics in China is also using an approach with allogeneic iPSC-derived cardiomyocytes, and Göttingen University is running a trial for patients with end- stage heart failure using engineered heart muscle composed of a mixture of iPSC- derived cardiomyocytes and stromal cells."

nature.com/articles/d41591-023

"Colograph
The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic. Scales vary and are usually life-size." by @madparreira

madalenaparreira.com/Colograph

Tools

"To complement existing tools of small-molecule-based inhibitors, we present a highly potent, novel catalytically-driven glucocorticoid receptors degrader, KH-103, based on proteolysis-targeting chimera technology."

biorxiv.org/content/10.1101/20

From Carl June et al

"A fundamental limitation of T cell therapies in solid tumors is loss of inflammatory effector functions, such as cytokine production and proliferation. Here, we target a regulatory axis of T cell inflammatory responses, Regnase-1 and Roquin-1, to enhance antitumor responses in human T cells engineered with two clinical-stage immune receptors."

pnas.org/doi/10.1073/pnas.2218

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