Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"In a 2004 paper, the World Health Organization’s former director of evidence, Chris Murray, and other researchers described the agency’s estimates as “serial guessing.” Without that baseline data, progress toward any given goal — to halve hunger, for example — could not be measured."

https://www.nytimes.com/2023/03/29/magazine/birth-death-tally.html

Gut tregs:

"Thus, Helios+ effector tTregs proliferate via CD28 and require neither ICOS nor MHCII for maintenance. In contrast, RORγt+ pTregs utilize CD28 and ICOS."

cc @mucida

https://www.mucosalimmunology.org/article/S1933-0219(23)00017-X/fulltext

"Before creating slides, write down the main points you hope to communicate. These might include an overarching question, the reason that question is important, your key results and any remaining issues. Try to connect the points into a smooth half-page narrative with a beginning, a middle and an end."

https://www.nature.com/articles/d41586-023-00832-5

PIEZO and NK cells
"However, the role of mechanosensing in regulating NK cell killing efficiency in physiologically relevant scenarios is poorly understood. In this study, we report that the responsiveness of NK cells is regulated by tumor cell stiffness. NK cell killing efficiency in 3D is impaired against softened tumor cells, while it is enhanced against stiffened tumor cells"
https://www.biorxiv.org/content/10.1101/2023.03.27.534435v1?med=mas

If you're in London:

"Berthe Morisot, extraordinarily a footnote in Impressionist history until a decade ago, arrives at London’s Dulwich Picture Gallery for her first UK exhibition in 70 years. It’s a wonderfully sympathetic, intelligent, enlightening show, placing Morisot at the heart of French painting while allowing her individuality to shine."

https://www.ft.com/content/d18f89ef-81e0-4d76-8e27-6347c8c3b88b

'Here, we describe the molecular profile of a thermosensory neuron pair in C. elegans experiencing different temperature stimuli. We find that distinct salient features of the temperature stimulus, including its duration, magnitude of change, and absolute value, are encoded in the gene expression program in this single neuron type, and we identify a novel transmembrane protein and a transcription factor whose specific transcriptional dynamics are essential to drive neuronal, behavioral, and developmental plasticity.'

https://www.cell.com/current-biology/fulltext/S0960-9822(23)00263-4

Monkey chalice by @hunchbacksociety #thehunchbacksociety #stoneware #ceramics #handmadeceramics #ArtMastodon #artgallery

https://madalenaparreira.com/Hunchbacksociety

Ancient shade

'Indeed, an anecdote that arose in antiquity paints exactly this picture: Dionysius, on the eve of the split, requested that Plato not speak ill of him back at the Academy, prompting Plato’s haughty reply: ‘May the gods forbid that we have any reason to speak of you at all.’'

https://aeon.co/essays/what-the-controversial-letters-of-plato-reveal-about-us