Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'In this study, we show that reversal of methylation silencing of STING in murine melanoma cell lines using a clinically available DNA methylation inhibitor can improve agonist-induced STING activation and type-I IFN induction, which, in tumor-bearing mice, can induce tumor regression through a CD8+ T cell-dependent immune response.'
Thiago Carvalho
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Did you know that you can find and post jobs on our job board? It’s free and easy to do. Check out the current list of available positions here: https://thenode.biologists.com/jobs/
Thiago Carvalho
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Patti Smith reads Oscar Wilde's stirring letter on suffering and transcendence, penned while imprisoned for loving whom he loved https://www.themarginalian.org/2016/11/07/patti-smith-reads-oscar-wilde-de-profundis/
What could possibly go wrong?
"Big Tech companies have been slashing staff from teams dedicated to evaluating ethical issues around deploying artificial intelligence, leading to concerns about the safety of the new technology as it becomes widely adopted across consumer products."
https://www.ft.com/content/26372287-6fb3-457b-9e9c-f722027f36b3
Thiago Carvalho
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@k4tj4 @r3rt0 @AleAliSousa @sofievalk
Wow, that's impressive: cerebellar cross-sections for 56 mammalian species, and data showing that "Ancestral estimations indicate that size and folding of the cerebrum and cerebellum increase and decrease concertedly through evolution."
"Diversity and evolution of cerebellar folding in mammals", by Heuer et al. 2023 https://www.biorxiv.org/content/10.1101/2022.12.30.522292v2
Question: does the pachyderm's (elephant) cerebellum also follow the proportionality rule with the cerebrum? I recall a commentary (Herculano-Houzel https://doi.org/10.1016/j.cub.2022.01.058 ) on how the elephant's cerebellum is 96% of all brain cells, when normally it's "only" 80%, at least in primates.
Thiago Carvalho
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Hi Mastodon folks. Twitter is getting quieter so I've clearly lost my previous @scotttishwaddell twitterverse. I'll start posting occasional lab news here too (instead) so please follow if that's of interest. We've lots in the pipeline and I'm missing learning about the other cool science out there that used to flash by my eyes on Twitter. Cheers, Scott. #Introduction #neuroscience #drosophila #dopamine
Thiago Carvalho
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In an open letter by eight European leaders to #bigtech companies, we stress the urgent need to take more efficient steps against disinformation.
Social media should not be used to destabilise democracies. Tech platforms also have a responsibility to make sure it doesn't happen.
🐦🔗: https://n.respublicae.eu/kajakallas/status/1641020254523383808
Thiago Carvalho
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UK politics
Remember folks, you must definitely not mention any parallels between 1930s Germany and the current government's plans to round up the "other" people and concentrate them into camps, because the poor little snowflake Tory MPs get offended if you do and it will make them cry
'In most cases, researchers rely on P values to establish the scientific or practical significance of their findings. However, statistical significance alone provides very little information that is useful for making inferences about scientific or policy significance. For this reason, we require authors to provide much more information than just P values — in this Editorial, we explain our requirements.'
Tregs move one step closer to the clinic - Regeneron is partnering with Sonoma ( founded by Bluestone, Rudensky, Ramsdell & Tang) targeting ulcerative colitis, Crohn's and "two other undisclosed indications".
'The Cancer Immunotherapy Data Science Grand Challenge, which ran on Topcoder from January 9 to February 3, aimed to uncover new ways to modify, or “perturb,” T cells to make them more effective at killing cancer cells to ultimately improve cancer treatment.'
Thiago Carvalho
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"The induction of cellular cytotoxicity requires that the NK cell contacts its target cell and establishes a lytic immunological synapse. Previous reports have revealed that membrane protrusions may be a component of immune synapses. Here, we explored whether changes in the topology of intratumoral NK cell membranes relate to the formation of lytic immunological synapses."
Thiago Carvalho
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"The revenue model of mega-journals is based entirely on charging article publication fees. The publishers increase these fees when a journal improves its impact factor ranking. The model secures high journal revenue but poses difficulties for authors with limited discretionary funds."
Thiago Carvalho
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Postdoctoral Associate / Scientist Biochemistry and Molecular Cell Biology @Uni_WUE
Join us to study SMC #DNA motor complexes by single-molecule #Microscopy, #StructuralBiology and #CellBiology at the JMU Würzburg Biocenter.
Thiago Carvalho
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I still have an open position for a 3 year postdoc in Berlin. If you’ve got grazing incidence X-ray scattering or diffraction experience and in-depth Python knowledge, please do not hesitate to apply! Lots of freedom, all the toys!
Thiago Carvalho
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It's hosted here if you want a play: http://pcwww.liv.ac.uk/~cci/reveal_ia/ImageAnalysisWithFiji.html
And all the source is available for reuse and reworking here:
https://bitbucket.org/davemason/imageanalysiswithfiji/src/master/
Thiago Carvalho
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Antisense oligos and personalised medicine.
"Susannah joins a small but growing group of patients who have received treatments designed just for them, called ‘N of 1’ therapies. Personalized medicine seemed to be just around the corner for decades, but in 2018, the corner had finally been turned when a custom-designed ASO made its clinical debut at Boston Children’s Hospital."
Thiago Carvalho
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Good news and another great application of immunotherapy checkpoint inhibitors that helps T cells stay switched on to kill cancer
Women in England with advanced cervical cancer to be offered new treatment
Thiago Carvalho
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Research Technician I or II – Tuveson Laboratory/CSHL Organoid Facility
#ScienceJobs #job
Cold Spring Harbor #UnitedStatesUS #ResearchTechnician
https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-research-technician-i-or-ii-tuveson-laboratory-cshl-organoid-facility-2/?feed_id=41544
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
