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"The new vaccine does not contain the live viruses that are in the polio vaccines currently used in some low- and middle-income countries. It adds what’s known as an inactivated polio component into a multifaceted shot that is already being used to protect young children against five other dangerous infections. A similar shot is already available in the United States and some European countries."

nytimes.com/2023/06/30/health/

'No federal regulations protect farmworkers—who are mostly noncitizen immigrants from Latin America, commonly live under the poverty line, and have few legal rights—from extreme heat. Farmworkers die from heat-related injuries at 20 times the rate of other laborers.'

theatlantic.com/science/archiv

"Here, we describe a patient with selective IgA2 deficiency (CD068) with concomitant small intestinal Crohn’s disease (CD) and duodenal and ileal inflammation. To our knowledge, this is the first case of IgA2deficiency with a potential link to inflammatory bowel disease (IBD). This report might provide insights into potential IgA2-specific functions."

jci.org/articles/view/167742

News from Gates & Wellcome
"Two leading medical charities will contribute about $550mn to fund a large-scale clinical trial of what would be the world’s first new tuberculosis vaccine for more than a century."

ft.com/content/fa4eb584-e347-4

"We report the genome assembly of a female Late Pleistocene woolly mammoth (Mammuthus primigenius) with twenty-eight chromosome-length scaffolds, generated using mammoth skin preserved in permafrost for roughly 52,000 years."

biorxiv.org/content/10.1101/20

"In a controversial move, Australia will become the world’s first country to allow the drugs psilocybin and MDMA to be prescribed by doctors to treat psychiatric conditions including depression and post-traumatic stress disorder. But many scientists are concerned that research has not yet conclusively shown that these drugs are safe or effective. And some clinicians fear that the regulation that will govern access to the drugs is insufficient."

nature.com/articles/d41586-023

If you're looking for a weekend podcast, here's a very interesting episode of Knowable on the placebo effect.

overcast.fm/+oWAyCyXD0?ref=the

"The study of Popova et al. highlights the importance of using human cell-based models to better understand the pathophysiological mechanisms of congenital rubella syndrome. It remains to be seen why and how the rubella virus specifically attacks microglia, and what its molecular targets are. Identifying the molecular cues released by other brain cells, which potentially increase infection, will be necessary to eventually develop therapies against congenital rubella syndrome."

elifesciences.org/articles/892

For Throwback Thursday, an episode of the @EMBO Podcast on the clinical use of to treat antibiotic resistant bacterial infection - with a brief stop at the Siege of Leningrad.
Featuring pediatric infectious disease physician Ameneh Khatami, historian Dmitriy Myelnikov, and Jessica Sacher of Phage Directory.

embo.org/podcasts/the-enemy-of

Kurt M. Fraser Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala
biorxiv.org/content/10.1101/20

At last! New data show that SARS-CoV-2 (Omicron in particular) preferentially infects blood group A cells. Receptor binding domain (RBD) of SARS-CoV-2 shows similarity to several galectins and binds better to ACE2 with A blood group antigen. tinyurl.com/47w7rumu

#glycotime

Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria | nature.com/articles/s41467-023 #proteomics

Very interesting piece by Vassilis Galanos on the use of in higher

I recently heard Vassilis talking about this, and it gave me a lot to think about!

🤖 🤖 🤖 🤖 🤖

teaching-matters-blog.ed.ac.uk

Why do these male leaf-cutter bees tuck their forelimbs under the thorax when resting? There were several other males, all kicking each other out of the flower patch.

Megachile sp. inaturalist.org/observations/1

#Pembroke1347 #iNaturalist #entomology #Hymenoptera #nativebees #insects

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