Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
According to the UN’s most recent climate assessment, temperatures today are on average higher than at any time in at least the last 100,000 years.
Given the burning of fossil fuels and clearing of land over the course of a century or so has pushed the climate beyond anything known by human civilisation, that is a long way from being meaningless.
#climateChange #climateCatastrophy #climateEmergency #climateBreakdown #tippingPoint
"This study highlighted a primordial PD-L1/BTLA coinhibitory axis that regulates CD8+ T cell activation in teleost fish and may act as an alternative to the PD-L1/PD-1 axis in mammals. It also revealed a previously unrecognized strategy for E. tarda immune evasion by inducing CD8+ T cell tolerance to target Mϕ cells through eliciting the PD-L1/BTLA checkpoint pathway."
#Immunology #zebrafish
Thiago Carvalho
boosted
The US American South and the "Lost Cause" of the Confederacy
@oliphant
Stuff I never learned in my History classes. And depending on where you lived, other states lied about this history.
Articles of Secession: https://web.archive.org/web/19980128034930/http://sunsite.utk.edu/civil-war/reasons.html
From this thread: https://hachyderm.io/@mekkaokereke/109789295728917242
"...I would get so mad at dudes I knew that downplayed the confederate flag, until I realized that their textbooks literally lied about the reasons for the civil war!
Showing them the articles of secession blew their mind. Some stopped rocking the flag.
Imagine how much less racist the US would feel if 10% of all confederate flags just disappeared."
Thiago Carvalho
boosted
What is mind/brain reductionism, in practice?
In Kandel's 2005 book, he lays out 5 tenants to "outline an intellectual framework designed to align current psychiatric thinking and training of future practitioners with modern biology". I regard this as a good snapshot of the "reductionism" that many quibble with, as it is practiced by the neuroscientists who adopt it. Would anyone disagree (either that this is reductionism or that this is a good snapshot of it?). Here are the principles.
Principle 1. All mental processes derive from operations of the brain.
Principle 2. Genes and their proteins are important determinants of the pattern of interconnections between neurons and how neurons function.
Principle 3. Alerted genes do not, by themselves, explain all of the variance of a given major mental illness. Social or developmental factors also contribute very importantly. Just as combinations of genes contribute to behavior, including social behavior, so can behavior and social factors exert actions on the brain by feeding back upon it to modify the expression of genes and thus the function of nerve cells. Learning, including learning that results in dysfunctional behavior, produces alterations in gene expression. Thus all of "nurture" is ultimately expressed as "nature".
Principle 4. Alternations in gene expression induced by learning give rise to changes in patterns of neuronal connections. These changes ... are responsible for initiating and maintaining abnormalities of behavior that are induced by social contingencies.
Principle 5. Insofar as psychotherapy or counseling is effective and produces long-term changes in behavior, it presumably does so through learning, by producing changes in gene expression ...
https://psycnet.apa.org/record/2005-05732-000
(Also available at archive.org).
"COVID-19 mRNA vaccination in pregnant people aids in preventing maternal SARS-CoV-2 infection and reduces risk of common adverse birth outcomes, with the booster conveying additional protection. We therefore recommend that pregnant people not only be vaccinated against COVID-19, but also stay up to date with their vaccination schedule."
#COVID #Covid19
https://www.thelancet.com/journals/landig/article/PIIS2589-7500(23)00093-6/fulltext
'According to Calvino, literature will continue to flourish in the next one thousand years and these six lines of literary heritage will expand far and wide. I have always liked Calvino and after reading this book, I like him even more.'
https://lithub.com/wang-xiaobo-on-the-limitless-mind-of-italo-calvino/
'We detected frequent introductions of multiple SARS-CoV-2 lineages in white-tailed deer, which subsequently became enzootic and co-circulated, and certain lineages persisted in white-tailed deer even after their decline in human populations. In addition, three cases of potential spillover from white-tailed deer back to humans were identified.'
Thiago Carvalho
boosted
ProMED warned the world about SARS, MERS and Covid-19. Now experts worry its future is in peril. https://www.statnews.com/2023/08/03/promed-early-warning-system-on-disease-outbreaks-appears-near-collapse/
"Mortality is contested ground, a place where different types of knowledge are in conflict. In Clark County, Nevada, for example, coroners spend weeks investigating possible heat-related deaths."
https://www.theatlantic.com/health/archive/2023/08/the-enigma-of-heat-related-deaths/674911/
'Proliferating cell nuclear antigen is critical to DNA replication and repair processes. Through a rational drug design approach, we identified a small molecule PCNA inhibitor, AOH1996, which selectively kills cancer cells.'
#Cancer
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00221-0
'The results indicate that there must be several different origins of these organic materials, and that the distribution and character of these on Mars is more complicated than we thought.'
https://www.science.org/content/blog-post/organic-compounds-all-over-mars
'Computerised chemical design is now well established, as AI drug discovery makes rapid progress in the pharmaceutical industry. What makes Chemify stand out, according to Cronin, is the way its “chemputer” technology extends to manufacturing the newly invented molecules.'
https://www.ft.com/content/be25204a-6ad6-4db5-bbf5-f819954d0ce5
"Since last October, the country has been led by Giorgia Meloni, the head of the hard-right Brothers of Italy party (its logo includes the flame adopted by Mussolini’s supporters after his demise). Before becoming prime minister, she said that rescue ships, which she called “ferries” and likened to human traffickers, should be sunk."
https://www.nytimes.com/2023/08/02/magazine/ghali-italy-migrants.html
Thiago Carvalho
boosted
Alguém do Rio de Janeiro tem um andador para idosos sobrando?
Tenho que levar um pro meu pai, mas ele não quer que eu gaste dinheiro 🤷🏼♂️
Já tô pensando em comprar um e envelhecer ele antes de entregar 🤦♂️
"There are around 200 species of malaria parasite that can infect mammals, birds and reptiles. P. vivax is the most widely distributed form of malaria parasite in humans, and it is dominant in the Western Pacific and in highly populated areas of Latin America and Asia."
Thiago Carvalho
boosted
Significant concerns about the new Alzheimer's drugs
Unpredictable, serious side effects {ARIA]
https://science.org/content/article/will-unpredictable-side-effects-dim-promise-new-alzheimer-s-drugs
Image benefit ≠ Clinical benefit
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2807943
Thiago Carvalho
boosted
Two bodies found drowned and ensnared in #GregAbbott's buoys; one was a child https://www.dallasnews.com/news/politics/2023/08/02/dead-person-found-in-texas-anti-migrant-buoys-that-mexico-and-justice-dept-want-removed/ #texas
Thiago Carvalho
boosted
Florida bans AP psychology over gender identity, sexual orientation lessons - Raw Story - Celebrating 19 Years of Independent Journalism
https://www.rawstory.com/florida-bans-ap-psychology-over-gender-identity-orientation-lessons/
Thiago Carvalho
boosted
Central Florida is a hot spot for leprosy, report says
According to a research letter published in the journal Emerging Infectious Diseases, Central Florida reported among the highest rates of leprosy in the United States. The region accounted for 81% of cases in Florida and nearly 1 out of 5 leprosy cases nationwide. #StrangeTimes https://kbin.social/m/StrangeTimes/t/289002
"While sea surface readings take the temperature of the top layer of the ocean, up to a few hundred feet deep, climate scientists have also been charting how much heat is being absorbed by the ocean as a whole. In short: A lot."
https://www.nytimes.com/interactive/2023/08/03/climate/ocean-temperatures-heat-earth.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
