Thiago Carvalho @cyrilpedia@social.cleverlibre.org

You go through a lot of interns...

'Until recently, the only reliable way to determine the age of a polar bear has been to extract a premolar and inspect its growth rings. “No researcher wants to do it,” Dr. Woodruff said'

https://www.nytimes.com/2023/08/10/science/wildlife-aging-epigenetic-clocks.html

"Multivalent antigen display is strongly associated with higher antibody titers and therefore likely has a direct influence on the interaction with B cells. Yet, mechanistic studies in vivo of how antigen valency affects the B cell response are very limited."
#Immunology

https://www.cell.com/immunity/fulltext/S1074-7613(23)00367-9

"New York is home to six species of Chiroptera that overwinter in the state; the animals cope with the cold by hibernating, usually underground, in caves or abandoned mine shafts. Dangling from the ceiling by their toes, the bats descend into a state of torpor so complete it resembles suspended animation. Because they don’t move, hibernating bats are easy to census."

https://www.nybooks.com/articles/2023/09/21/spored-to-death-blight-fungi-and-the-coming-pandemic/

Closing a loop: The entire modern field of regulatory T cells emerged from the ashes of the suppressor T cell field because of experiments showing destruction of the reproductive system following neonatal thymectomy.

"We found that Treg depletion induces severe autoimmune orchitis and epididymitis, manifested by an exacerbated immune cell infiltration [CD4 T cells, monocytes, and mononuclear phagocytes (MPs)] and the development of antisperm antibodies (ASA)."

#Immunology

https://www.pnas.org/doi/10.1073/pnas.2306797120

In case you missed it: Matthias Tschöp told me the story of the science behind the popular new class of anti-obesity drugs.

Listen to "Obesity is a Brain Disease" 🎧 👇

https://open.spotify.com/show/5tiWyc9zrQeFt0I3Q3gXab

'We explored CDN-mediated immunity in 14 Drosophila species covering 50 million years of evolution and found that 2′3′-cGAMP and 3′2′-cGAMP failed to control infection by Drosophila C virus in D. serrata and two other species.'

https://www.cell.com/immunity/fulltext/S1074-7613(23)00362-X

I love this scene

https://www.youtube.com/watch?v=ZU1WqjMVtwE

'The greatest threat to our democracy comes not from demagogues like Mr. Trump or even from extremist followers like those who stormed the Capitol on Jan. 6 but rather from the ordinary politicians, many of them inside the Capitol that day, who protect and enable him.'

https://www.nytimes.com/2023/09/08/opinion/trump-republicans-spain-brazil.html

'Shaw said the apparent similarity between Attomarker and Theranos, the fraudulent US blood-testing company founded by Elizabeth Holmes, “always comes up when I’m talking to investors. The difference is we’ve got the technology to work and demonstrated it, which they never did.”

https://www.ft.com/content/89bf9d61-7b5c-411e-97ef-c6f72722a502

'Under the terms of the deal, the United Kingdom will pay in €2.6 billion per year to be an ‘associate’ member of Horizon Europe for the rest of the scheme’s current term, set to end in 2027.'

https://www.nature.com/articles/d41586-023-02812-1

'Desde muy joven, Saura mostró su interés por diferentes disciplinas artísticas. La fotografía, la pintura y la música formaban parte del calor familiar. Pero la pasión por el cine nació en la calle, cuando en el Madrid pobre y apaleado de la posguerra el pequeño se escapaba a las sesiones de los cines de barrio cercanos a su casa familiar de la avenida de Menéndez Pelayo para ver una y otra vez la versión de los años treinta de El prisionero de Zenda.'

https://elpais.com/eps/2023-09-06/las-memorias-visuales-de-carlos-saura.html