Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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@cyrilpedia hey that’s @meikeesther with a really great article. Sent it to everyone I know.
"This blog is highly biased on my n=1 experience. I am a Caucasian woman, married without children. I was asked about my marital status and the “moveability” of my husband at nearly all on-site interviews, and about children during half of them."
Thiago Carvalho
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Antoine Canat, Pierre Therizols and colleagues find that DAXX plays an essential role in the maintenance and 3D organisation of constitutive heterochromatin, which protects ESC viability.
Highlight: https://journals.biologists.com/jcs/article/136/19/e136_e1902/333451/Coordinating-chromatin-under-construction-with
Article: https://journals.biologists.com/jcs/article/136/19/jcs261092/333449/DAXX-safeguards-heterochromatin-formation-in
Find out more about this research in our ‘First person’ interview with Antoine Canat: https://journals.biologists.com/jcs/article/136/19/jcs261613/333445/First-person-Antoine-Canat
Thiago Carvalho
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What is teleology today?
I've tripped over references to "teleology" from a 1968 paper and I'm trying to wrap my head around it. It's described as controversial, to say the least (CW: "teleology as a lady without whom no biologist can live without but he is ashamed to be seen with her in public." 🙄). https://link.springer.com/chapter/10.1007/978-3-642-88343-9_3
Teleological explanations are defined as, "the explanation of phenomena in terms of the purpose they serve rather than of the cause by which they arise."
Do brain researchers use it today? For instance, are normative models (like Bayesian models of decision making) teleological? There, researchers typically define the optimal solution for a problem and compare real behavior to it.
What about the neuroconnectionist program? There, researchers typically define a problem that needs to be solved (like labeling objects in images), train an ANN to perform it, and compare that ANN to the brain.
https://www.nature.com/articles/s41583-023-00705-w
The few papers I've found that discuss teleology versus Normativity were impenetrable. Thanks in advance for pointers in the right direction!
"A new report from Tufts Medical Center’s New Drug Development Paradigms (NEWDIGS) program shows that cell and gene therapies for orphan diseases and hematological cancers are two to 3.5 times more likely to be successful than other types of treatments for similar conditions, or as compared to the entire drug pipeline."
"She credits her postdoctoral research programme, the US National Institutes of Health’s institutional research and academic career development award (IRACDA), with teaching her about great mentorship."
"Educating doctors is a long and expensive process, but not every country can reward its graduates equally. Health spending per capita varies drastically in EU countries, from €816 per year in Romania to more than €4,000 in Luxembourg, Germany and other Western European countries. And so doctors and nurses follow the money."
"Up to 18 children from the UK, Spain and the US are being recruited to the study, which aims to transform treatment of auditory neuropathy, a condition caused by the disruption of nerve impulses travelling from the inner ear to the brain."
#genetherapy
https://www.ft.com/content/fc34dbe1-db03-4dd7-91a2-3cc3a367aa01
Thiago Carvalho
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Hardest hit by the exodus of doctors and nurses: the EU's newest members, plus crisis-hit Portugal and Greece, according to POLITICO's analysis of Commission data.
Thiago Carvalho
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The situation in North Carolina highlights just how tenuous a hold citizens have on democracy.
https://open.substack.com/pub/aaronrupar/p/north-carolina-gop-power-grab-roy-cooper
Thiago Carvalho
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NTRO Research Study Specialist
Moffitt Cancer Center
See the full job description on jobRxiv: https://jobrxiv.org/job/ntro-research-study-specialist/?feed_id=61856
#ScienceJobs #hiring #research
Tampa #UnitedStatesUS #ResearchTechnician #Researcher #Scientist
https://jobrxiv.org/job/ntro-research-study-specialist/?feed_id=61856
Thiago Carvalho
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Welcome to our new Editor, Renata Basto. Renata will handle papers focussing on the cell cycle, centrosomes, chromosomes, mitosis, genetic instability, mitotic spindle, microtubules, aneuploidy and polyploidy. If you have an article on one of these topics, consider sending it our way! https://bit.ly/45s0gwx
"Suddenly you become a public figure being asked to do all sorts of things: to give lectures, quite often on topics you know little about; to sit on committees and reviews you are not always well qualified to be on; to visit countries you have barely heard of; to sign endless petitions on what are probably good causes, but you never know. It is like having a whole new extra job, with upwards of 500 requests a year. It is impostor syndrome on steroids."
"Además, unos meses antes del conflicto, X eliminó el acceso a una herramienta de datos que era gratuita para los académicos y que se empleaba para identificar las cuentas que se dedicaban a difundir información falsa. Los expertos en verificación de información aseguran que la avalancha de falsedades nunca ha sido igual."
"We identified approximately 13,000 sensor histidine kinases, chemoreceptors, receptors involved in second messenger homeostasis and Ser/Thr phosphatases from 8,000 bacterial and archaeal species that contain the amine-recognizing motif."
#Microbiology #Metabolism
Thiago Carvalho
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KRAS update
"Here are the FDA briefing documents for the meeting being held today (Thursday, October 5). If you read Amgen’s press releases from the last two or three months and then read this stuff, you will feel as if you have stepped through a portal into another dimension."
@dereklowe.bsky.social
https://www.science.org/content/blog-post/confirmatory-trial-trouble-kras
Thiago Carvalho
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Last night, I deactivated my own Twitter account and walked away from an audience of 30,000 followers.
Because I no longer believe a moral argument can be made for staying on Twitter/X in 2023.
https://joanwestenberg.medium.com/there-is-no-moral-argument-for-staying-on-twitter-x-cdef14b04730
Thiago Carvalho
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The second
@darwintreelife
#Drosophila genome! Drosophila funebris! https://wellcomeopenresearch.org/articles/8-437
Thiago Carvalho
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Next week's DEE External Seminar welcomes S. Lorena Ament-Velásquez (hosted by Miya Pan, Schwander group) for a talk on self-nonself recognition systems and speciation. Oct 18 at 12:15, Biophore Amphitheater or online https://rec.unil.ch/lives/live_80807
Thiago Carvalho
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'An immunoprevention strategy for #Alzheimer's disease is required that will integrate the findings from clinical trials with mechanistic insights from preclinical disease models to select promising antibodies, optimize the timing of intervention, identify early biomarkers, and mitigate potential side effects.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
