Thiago Carvalho @cyrilpedia@social.cleverlibre.org

#Cichlids and other fish species you definitely don't have in your #aquarium.

From the understudied region of Northern #Zambia being situated between two African Great Lakes: Lake #Tanganyika and Lake #Malawi.

Schedel et al. 2023
https://www.sciencedirect.com/science/article/pii/S0380133023002381

Selective macroautophagy of the #EndoplasmicReticulum (ER) and the #nucleus, known as ER-phagy and nucleophagy respectively, are poorly understood. A study in #FissionYeast reveals that conserved ER-shaping protein Yep1 (REEP1-4 ortholog) is required for these processes; in its absence, #ERphagy/#nucleophagy cargo structures accumulate in the cytoplasm #PLOSBiology https://plos.io/464ZfuI

How does #CorrectiveFeedback influence subsequent choices? This computational study reveals that humans don't consider such feedback as a reward for value but as evidence to learn about the statistical structure of a perceptual task, offering a principled account of the historical effects in both directions of time #PLOSBiology https://plos.io/46bc0nk

DIR PRMS AND REG AFFAIRS

Moffitt Cancer Center

See the full job description on jobRxiv: https://jobrxiv.org/job/dir-prms-and-reg-affairs/?feed_id=64816

#ScienceJobs #hiring #research
Tampa #UnitedStatesUS #Director #ProjectManager #Scientist
https://jobrxiv.org/job/dir-prms-and-reg-affairs/?feed_id=64816

'One frustrated modeller observed a lack of ethnic and gender diversity among scientists recruited to Sage, and a failure to stress-test assumptions; one Downing Street adviser, a rarity for having attended a state school, lamented that these missing perspectives created “problems in decision-making, policy development and culture”.

https://www.ft.com/content/4c378024-c3ec-4171-a0e6-4c5ad159336e

"The Brazilian authorities, however, say it was something far more sinister: a meeting of the Hammerskins, a neo-Nazi group founded in Dallas in 1988 that they say has recently found its way thousands of miles south, to Brazil’s most starkly conservative region, reflecting a surge in far-right extremists in Latin America’s largest nation."

https://www.nytimes.com/2023/11/07/world/americas/brazil-neo-nazis-extremism.html

"We conclude that expression of TEs is tightly regulated in TILs during establishment of exhaustion and reprogramming by ICB. Analyses of TE expression on single cells and bulk populations open opportunities for understanding immune cell identity and heterogeneity, as well as for defining cellular gene expression signatures and disease biomarkers."
#Immunology #Immunotherapy

https://www.science.org/doi/10.1126/sciimmunol.adf8838?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial

"The whole episode left me wondering what purpose it serves to penalize those who want to stay at the same institution for multiple career stages. It’s often said in academia that 'moving around a lot is necessary.' But the reality is that moving is a huge barrier for many scientists, including those with spouses, children, aging parents, disabilities, and cultural backgrounds that emphasize a close-knit extended family community—the kinds of people academia is actively trying to recruit to its ranks."

https://www.science.org/content/article/i-didn-t-want-relocate-postdoc-fellowship-reviewers-penalized-me-it?utm_campaign=SciMag&utm_medium=ownedSocial&utm_source=LinkedIn

4% of ~58,000 individuals assessed carried an actionable gene variant that is linked with reduced lifespan, such as BRCA2 with associated reduced lifespan by 7 years and 7-fold risk of dying from various cancers

https://www.nejm.org/doi/full/10.1056/NEJMoa2300792?query=featured_home

Tickets for the Ig Nobel Face-to-Face event at MIT this coming weekend are sold out. But fear not — later this year, we will webcast a video-recording. https://improbable.com/2023/10/17/ig-nobel-face-to-face-event-at-the-mit-museum/

I've tried to straddle the line on Twitter, hoping to keep dialogue open across communities and avoid furthering the polarisation by leaving the Birdsite with no advocates for better practice.

But I'm out. Deleting account today. I've been primarily Mastodon since Nov 2022 anyways. Celebrating one year! #MastodonMigration #twitterMigration
https://www.nature.com/articles/d41586-023-03483-8

Our most read article from August is ‘Repetitive nociceptive stimulation elicits complex behavioral changes in Hirudo: evidence of arousal and motivational adaptations’ by Jessica Hoynoski & co.

Read the full research article: https://journals.biologists.com/jeb/article/226/16/jeb245895/325884

#Science #Biology #Zoology

Important article in Nature… So Musk isn’t just trying to destroy what was undoubtedly a nuisance to billionaires (Twitter was once an excellent muckraking tool).. He’s using it to debase news coverage of current events: Reporters who visit “X” get exposed to Elon’s hand crafted firehose of misinfo-sewage 🫥😬😵‍💫 #SocialMedia #Misinformation #Reporting #Gaza #Israel https://www.nature.com/articles/d41586-023-03483-8

It's going to take all the running in the world just to stand still.

"A machine-learning tool can easily spot when chemistry papers are written using the chatbot ChatGPT, according to a study published on 6 November in Cell Reports Physical Science1. The specialized classifier, which outperformed two existing artificial intelligence (AI) detectors, could help academic publishers to identify papers created by AI text generators."

https://www.nature.com/articles/d41586-023-03479-4?utm_medium=Social&utm_campaign=nature&utm_source=Twitter#Echobox=1699287337

"Uma startup de saúde ginecológica do Reino Unido lançou, recentemente, um tampão que funciona como um teste PCR para diagnóstico de doenças sexualmente transmissíveis (DST) nas mulheres. Segundo a empresa Daye, o tampão funciona como substituto do cotonete ou espéculo vaginal utilizados nos testes de rastreio e consegue igualmente identificar clamídia, gonorreia, microplasma, ureaplasma e tricomonas."

https://www.publico.pt/2023/11/06/p3/noticia/startup-britanica-lanca-tampao-detecta-doencas-sexualmente-transmissiveis-2069180

"Here, we describe an mRNA-based platform enabling delivery of pathogen-specific immunoglobulin A (IgA) monoclonal antibodies into mucosal secretions. The platform consists of synthetic mRNA encoding IgA heavy, light, and joining (J) chains, packaged in lipid nanoparticles (LNPs) that express glycosylated, dimeric IgA with functional activity in vitro and in vivo."

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00430-5

@Daojoan Really good long read last week on how the myth of "Man the Hunter" came about and how it got trashed by, you know, evidence.
https://www.scientificamerican.com/article/the-theory-that-men-evolved-to-hunt-and-women-evolved-to-gather-is-wrong1/