Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Given the ability of low-affinity Glut2 to bidirectionally transport glucose along a concentration gradient, its prompt removal from the cell surface is instrumental to prevent glucose leakage in glucose-depleted environments. In contrast, the high-affinity Glut1, whose expression does not decrease in inflammatory sites, can sustain glucose uptake in conditions of low glucose availability.'
Thiago Carvalho
boosted
A comprehensive #SARSCoV2 & #COVID19 review
Part 1: Intracellular overdrive for #SARSCoV2 infection
https://www.nature.com/articles/s41431-022-01108-8.pdf
Thiago Carvalho
boosted
Although expression of #MDR efflux pump AcrAB-NodT deforms the bacterial envelope, @ViollierPat &co show that homeostatic control by TipR co-induces co-chaperone DjlA, which boosts efflux pump assembly in anticipation of envelope stress #AMR #PLOSBiology https://plos.io/48pzzKX
Bats & beyond
"Further analysis of IFITM repertoires in 205 mammals reveals that alternative splicing is a ubiquitous strategy for IFITM diversification, albeit less widely adopted than gene duplication."
#Preprint #immunology
Thiago Carvalho
boosted
#Antibody Specificity: A strong case for third-party testing. #Immunology #Biochemistry https://elifesciences.org/articles/93329?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights
Thiago Carvalho
boosted
Senior Staff Scientist
FIB-SEM Collaboration Core
Senior Staff Scientist position available in the FIB-SEM Collaboration Core (F-SCC) (https://medicine.yale.edu/fib-sem/) of Yale School of Medicine.
See the full job description on jobRxiv: https://jobrxiv.org/job/fib-sem-collaboration-core-27778-senior-staff-scientist/?feed_id=67221
#biochemistry #bioengineering #bioimaging #Biology #Biotechnol...
https://jobrxiv.org/job/fib-sem-collaboration-core-27778-senior-staff-scientist/?feed_id=67221
Thiago Carvalho
boosted
The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
Thiago Carvalho
boosted
December 7, 1857, birthday of Belgian-French vertebrate paleontologist Louis Dollo.
An entire herd of Iguanodon fossils discovered in a coal mine near the Belgian town of Bernissart, helped him to reconstruct the anatomy of this dinosaur species. He also found that the "horn" that G. Mantell originally placed on the animal's snout was really a thumb spike 🦖
"Rebecca, 28, a full-time PhD student in biosciences from Liverpool, and her partner, an Australian national working in higher education, are among thousands of couples facing separation and financial uncertainty because of the government’s decision to overhaul immigration rules."
Thiago Carvalho
boosted
Bispecific T-cell engager targeting DLL3 & CD3
"Tarlatamab, administered as a 10-mg dose every 2 weeks, showed antitumor activity with durable objective responses and promising survival outcomes in patients with previously treated small-cell lung cancer. No new safety signals were identified"
#Immunology #Immunotherapy #LungCancer
https://www.nejm.org/doi/full/10.1056/NEJMoa2307980?query=featured_home
Thiago Carvalho
boosted
“El caso es que esos hematófagos se extinguieron, y no sabemos por qué. Tal vez hubo más recursos para la hematofagia durante el cretácico temprano y luego los recursos disminuyeron o la competencia entre moscas hematófagas llevó a la extinción de los taxones menos adaptados”
Thiago Carvalho
boosted
“For years the EU has been trying to agree on a new system to respond to people moving or fleeing to Europe. The agreement now on the table would in many ways worsen existing legislation, and risks increasing suffering at European borders.”
Thiago Carvalho
boosted
'Virus-based vectors — particularly those based on adeno-associated virus (AAV) and lentiviruses — have dominated the first wave of gene therapies to gain regulatory approval. But their widespread deployment in dozens of clinical trials has exposed their limitations.'
Thiago Carvalho
boosted
"This article is dedicated to researchers who aspire to more than just a temporary solution for data analysis. It's for those who are committed to developing a deeper understanding and proficiency in bioinformatics."
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Ancient #Balkan #genomes trace the rise and fall of #Roman Empire's frontier, reveal #Slavic #migrations.
#archaeogenetics #anthropology
https://phys.org/news/2023-12-ancient-balkan-genomes-fall-roman.html
Thiago Carvalho
boosted
If we designed houses like we design cities—there wouldn't be a lot of room for living left.
Thiago Carvalho
boosted
New article! Read Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota https://www.nature.com/articles/s41522-023-00462-9?utm_source=dlvr.it&utm_medium=mastodon in npj Biofilms
"Heuer et al. then set out to find which computational model of evolution was able to recreate the anatomies of the cerebellums found in the different mammalian species. They found that a stabilising model – that is, when animals that are straying away from their common ancestor randomly evolve back to these initial properties – worked best. Using this model, Heuer et al. estimated that the organism most mammals descended from probably had a cerebellum similar to the one found in an animal known as the rock hyrax (Figure 1B)."
Thiago Carvalho
boosted
From infamy to ingenuity—#bacterial hijack mechanisms as advanced #genetic tools.
#phytoplasma #biotechnology #SAP05 #26S_proteasome #ubiquitin
https://phys.org/news/2023-12-infamy-ingenuitybacterial-hijack-mechanisms-advanced.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
