Thiago Carvalho @cyrilpedia@social.cleverlibre.org

National wastewater data suggest this winter could see the highest number of #coronavirus infections occurring during any given week since the first #Omicron wave began in fall 2021. https://www.latimes.com/california/story/2024-01-06/covid-19-intensifies-across-california-with-the-worst-likely-still-to-come
There’s definitely a huge spike in the outpatient COVID numbers, and just general viral illnesses, as well as a more modest uptick in respiratory illnesses severe enough to require hospitalization.
#COVID #LongCovid #GlobalHealth #WomensHealth #flu #RSV

"More than 1,600 ancient genomes have helped to trace the roots of a host of genetic traits found in modern Europeans. The genomes suggest that many characteristics — including a heightened risk for multiple sclerosis — were carried to Europe by people who migrated to the continent in three distinct waves starting around 45,000 years ago."

https://www.nature.com/articles/d41586-024-00024-9

A journey of 11,000km ends at the same lab memes.
#Kyoto

Link to Time magazine story "Is It Dangerous to Keep Getting Covid-19?", below.
"People who had multiple infections were three times more likely to be hospitalized for their infection up to six months later than those who only got COVID-19 once, and were also more likely to have problems with clotting, gastrointestinal disorders, kidney, and mental-health symptoms. The risks appeared to increase the more infections people experienced."
#covid #CovidIsNotOver #MaskUp
https://time.com/6553340/covid-19-reinfection-risk/

A little taste of Vietnam in Kyoto.

"The F.D.A.’s handling of Singulair illustrates systemic gaps in the agency’s approach to addressing troubling side effects from medicines approved long ago — and to warning the public and doctors when serious issues arise. The agency had flagged the 2020 warning label, known as a “boxed warning,” to physicians’ groups, but it had not required that doctors be educated about the drug’s side effects."

https://www.nytimes.com/2024/01/09/health/fda-singulair-asthma-drug-warning.html

'La Comisión Europea acaba de aprobar 38 millones de euros que, durante los próximos tres años (hasta 2026), sostendrán la infraestructura digital puntera para estudiar el cerebro EBRAINS (European Brain Research Infrastructures), una plataforma de investigación colaborativa diseñada para hacer avanzar la neurociencia y mejorar la salud cerebral.'

https://elpais.com/salud-y-bienestar/2024-01-09/europa-se-lanza-a-descifrar-el-cerebro-con-un-nuevo-impulso-a-la-neurociencia-digital.html

Tools.

'In zebrafish, the zGRAD degron system (18), adapted from the Drosophila deGradFP system (19), is used to target POIs tagged with a GFP-based fluorescent protein for degradation, using an anti-GFP nanobody fused to an F-box protein. The degradation of the POI is mediated through polyubiquitination and the proteasome. However, these approaches have not been tested on many endogenous targets in vertebrates (20, 21) and notably not on proteins integrated into tight subcellular structures such as the sarcomere.'

https://www.pnas.org/doi/10.1073/pnas.2309842121

It's a great book:

"Zemon Davis’s book is about an impostor in the same century: eight years after a man named Martin Guerre abandoned his life in a small French village, another man turned up, claiming to be him."

https://www.nybooks.com/online/2024/01/07/new-money-medieval-merchants/

Ancient DNA reveals origins of multiple sclerosis in Europe

https://www.nature.com/articles/d41586-024-00024-9

@luckytran My sister’s nursing home outside of #cleveland just called to say 17 people (13 residents and four employees) tested positive for #covid today. SMDMH: Shaking my damned masked head.

You know the kind of experiment that has a lot of steps and it's scary because there are a lot of things that can go wrong but if it works OH-BOY-if-it-works? That's the experiment I am doing right now

The only thing we know about the five Nazi newsletters Substack says it took down is this, from the Verge:

"[N]one of the publications removed had paid subscriptions enabled and accounted for 'about 100 active readers in total.'"

This is not a serious response from the Nazi bar. In fact, it is an "up yours" to everyone who has asked the platform to stop being hypocritical.

https://www.theverge.com/2024/1/8/24030756/substack-nazi-newsletter-content-moderation

'It’s a reality that has become increasingly common for young people as unpaid internships boom across much of the world. But in the EU – where the parliament has repeatedly described unpaid internships as a “form of exploitation of young workers and a violation of their rights” – relief may soon be on the way.'

https://www.theguardian.com/world/2024/jan/02/ramen-noodles-budget-eu-moves-to-end-exploitation-of-unpaid-internships

'A number of employees debated Musk’s actions in the company-wide #social-watercooler channel, and, the day after, we woke up to find many of their accounts gone. “So is this like a Candyman situation?” someone posted. “Mention Elon three times and we get deactivated?”

https://www.newyorker.com/tech/annals-of-technology/what-we-lost-when-twitter-became-x

"The woman’s case wasn’t a one-off. Just about every time an embryo implants and begins to grow, it dispatches bits of itself into the body housing it. The depositions begin at least as early as four or five weeks into gestation. And they settle into just about every sliver of our anatomy where scientists have checked—the heart, the lungs, the breast, the colon, the kidney, the liver, the brain."

https://www.theatlantic.com/science/archive/2024/01/fetal-maternal-cells-microchimerism/676996/

"Na última avaliação dos centros de investigação portugueses foram disponibilizados 420 milhões de euros para financiar os quatro anos entre 2020 e 2023 – ou 105 milhões por ano. Agora, no próximo ciclo de 2025 a 2029, a verba avançada pela Fundação para a Ciência e a Tecnologia (FCT) é de 525 milhões de euros – ou 105 milhões por ano. Ou seja, durante toda a década, entre 2020 e 2029, não existem quaisquer aumentos no dinheiro atribuído às unidades de investigação científica em Portugal."

https://www.publico.pt/2024/01/08/ciencia/noticia/dinheiro-centros-investigacao-nao-vai-aumentos-durante-decada-2076071

Course on "Quantitative Imaging: From Acquisition to Analysis"

Application deadline: January 31st

Course dates: April 1-16

Location: Cold Spring Harbor

Instructors: Jennifer Waters, @bethcimini @florianjug Hunter Elliott, Talley Lambert, Suliana Manley.

Financial aid is available to help offset tuition costs.

https://meetings.cshl.edu/courses.aspx?course=C-QICM&year=24

#microscopy #imaging #biology #bioimage