Well this is an epic bummer: taking Paxlovid didn’t reduce the risk of #LongCovid in vaccinated people
'Que se lembre a determinação e coragem dos que o fizeram, que se fale por comparação com os anos da ditadura, é bom. O que é mau é que se comemore a data mais ou menos por obrigação como se fosse um dia santo republicano e laico, e não a Revolução de 25 de Abril.'
A fine public service from @molly0xfff -- she didn't just leave Substack for an open-source platform (Ghost), but now has posted, in detail, how she did it.
If you're considering this move with your own newsletter, this is must-reading.
Even if you're not personally affected by this, read it anyway for great info about how software works.
"One step towards understanding why mushrooms would go to all this effort to make psilocybin is to trace its evolution. To that end, a team of American, Mexican, and British scientists have reconstructed a deep history of psilocybin, which they published this week in (PNAS)"
https://buttondown.email/carlzimmer/archive/fridays-elk-january-12-2024/
"In their recent study, Kevin Aslett, a political scientist at the University of Central Florida in Orlando, and his colleagues found that people who used Google Search to evaluate the accuracy of news stories — stories that the authors but not the participants knew to be inaccurate — ended up trusting those stories more. This is because their attempts to search for such news made them more likely to be shown sources that corroborated an inaccurate story."
Oldie but goldie.
"Many neurodevelopmental defects are linked to perturbations in genes involved in housekeeping functions, such as those encoding ribosome biogenesis factors. However, how reductions in ribosome biogenesis can result in tissue and developmental specific defects remains a mystery. Here we describe new allelic variants in the ribosome biogenesis factor AIRIMprimarily associated with neurodevelopmental disorders."
#Preprint #neuroscience
https://www.biorxiv.org/content/10.1101/2024.01.09.574708v1?rss=1
'A vacinação sazonal contra a covid-19 vai ser alargada, a partir de segunda-feira, à população com mais de 18 anos, sendo também nessa data que os mais de 50 anos podem ser vacinados contra a gripe, segundo a DGS.
A Direção-Geral da Saúde (DGS) refere que a vacinação sazonal de outono-inverno 2023-2024 contra a covid-19 vai ser alargada à população entre os 18 e os 59 anos e a vacinação contra a gripe às pessoas dos 50 aos 59 anos.'
"Getting something into a Gram-negative bacterium isn’t easy. Though the sum total of its boundary layers is thinner than for a Gram-positive, the outer and inner membranes are separated by a no-man’s land known as the periplasmic space (which contains the thinner peptidoglycan wall). The arrangement makes the cell much less permeable, apart from small water channels. Antibiotics that can get into and kill Gram-negative bacteria are therefore often small molecules, around a hundredth the size of a typical protein."
You are here.
[Welcome to 2024 and the past 800,000 years of atmospheric CO2.]
'The food system in Gaza has collapsed completely. The health system has collapsed. Basic infrastructure for clean water and sanitation has collapsed. According to the Famine Review Committee, the people of Gaza are facing a real prospect of famine'
https://www.lrb.co.uk/blog/2024/january/starvation-as-a-method-of-warfare
"Not only is science today more expensive, but it is also bigger and more multidisciplinary. There is a need for researchers and entrepreneurs to collaborate. A growing number of incubator and accelerator programs offer networking, support and advice to early-stage and mid-stage companies, globally, without the need for a lot of preliminary data."
'Putin’s goal is not just a little more turf. Russia has a lot of that. His telos—his endgame—is the destabilization, the overcoming, of the whole Western order. This sounds fantastical to Americans because we’re an ahistorical people. That doesn’t mean we’re ignorant of history, although there’s a great deal of that, too. It means the categories with which we apprehend the world are not defined by the past, and we can’t really understand how it could be otherwise.'
https://www.vanityfair.com/news/2017/01/the-secret-source-of-putins-evil?ref=thebrowser.com
Guinessomics
""The present yeast used to make Guinness stout brewed in Dublin, Ireland, can be traced back to 1903, but its origins are unknown. To that end, we used Illumina and Nanopore sequencing to generate whole-genome sequencing data for a total of 22 S. cerevisiae yeast strains: 16 from the Guinness collection and 6 other historical Irish brewing."
New study: "Open peer review significantly increased the uptake of #preprints by #policies… [as] measured by preprints being cited in policy documents."
https://academic.oup.com/spp/advance-article-abstract/doi/10.1093/scipol/scad083/7514709
This is so sad. It's almost as if measles vaccination works v well at preventing measles! 🤦♂️
#infectiousdiseases #vaccine #vaccination #measles
Measles cases surge in England and Wales fuelled by vaccine hesitancy over MMR jab | UK News | Sky News
> In England and Wales, there were 1,603 suspected cases of measles in 2023, new figures show. That's an increase from 735 in 2022 and just 360 the year before.
This is funny, but also actually a really bad sign for general enshittification of the web. The most alarming detail here is that Amazon is actually promoting the use of LLMs to create fake ad copy.
Opinion: What STAT readers think about JPM's locked lactation room, covering weight loss drugs, and more
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com