jonmoulton @jonmoulton@social.cleverlibre.org

Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome. https://www.heartrhythmjournal.com/article/S1547-5271(23)00148-0/fulltext #Morpholino

Single-cell atavism reveals an ancient mechanism of cell type diversification in a sea anemone. https://www.nature.com/articles/s41467-023-36615-9 #Morpholino

CCN6 influences transcription and controls mitochondrial mass and muscle organization. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201533R #Morpholino

EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318110 #Morpholino

Therapeutic Phosphorodiamidate Morpholino Oligonucleotides, an RNA mimic: Physical Properties, Solution Structures, and Folding Thermodynamics. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00027-6 #Morpholino

The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus). https://royalsocietypublishing.org/doi/10.1098/rsob.220235 #Morpholino

Milk fat globule epidermal growth factor 8a regulates neurogenesis in telencephalon and affects larval behavior in zebrafish. https://www.liebertpub.com/doi/10.1089/scd.2022.0247 #Morpholino

Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. https://www.frontiersin.org/articles/10.3389/fcell.2023.1142586/full #Morpholino

(article) Proof-of-Concept Study Shows Promise of Complementary Gene Therapy Approach in Duchenne Muscular Dystrophy https://pediatricsnationwide.org/2023/02/10/proof-of-concept-study-shows-promise-of-complementary-gene-therapy-approach-in-duchenne-muscular-dystrophy/ #Morpholino

Citations and abstracts of all the primary #Morpholino papers I toot also go into this online searchable database of Morpholino publications:
http://pubs.gene-tools.com/

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes. https://ashpublications.org/blood/article/141/6/645/486790/Human-genetic-defects-in-SRP19-and-SRPRA-cause #Morpholino

Converging Role for REEP1/SPG31 in Oxidative Stress. https://www.mdpi.com/1422-0067/24/4/3527 #Morpholino

Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: study protocol for a phase I/II clinical trial. https://www.medrxiv.org/content/10.1101/2023.02.06.23285500v1 #Morpholino

Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. https://www.mdpi.com/1422-0067/24/4/3253 Vivo-#Morpholino

Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. https://www.pnas.org/doi/10.1073/pnas.2212212120 #Morpholino

Gaucher disease protects against tuberculosis. https://www.pnas.org/doi/10.1073/pnas.2217673120 #Morpholino

The Moulton lab (My wife Hong at OSU, the PPMO lady) has it's stable domain name now. moultonlab.org
#Morpholino-peptide conjugates

Ubiquitylation of BBSome is required for ciliary assembly and signaling. https://www.embopress.org/doi/full/10.15252/embr.202255571 #Morpholino

Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. https://journals.lww.com/jasn/Abstract/2023/02000/Genetic_Variants_in_ARHGEF6_Cause_Congenital.14.aspx #Morpholino

Confined environments induce polarized paraspeckle condensates. https://www.nature.com/articles/s42003-023-04528-4 #Morpholino