jonmoulton @jonmoulton@social.cleverlibre.org

Mucociliary Wnt signaling promotes cilia biogenesis and beating. https://www.nature.com/articles/s41467-023-36743-2 #Morpholino

Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. https://www.nature.com/articles/s41467-023-36612-y #Morpholino

Migration and establishment of progenitor pool of melanocytes is governed by SEMA3E-PLXND1 signaling. https://www.biorxiv.org/content/10.1101/2023.02.28.530560v1.full #Morpholino

Temporal single-cell transcriptomic analysis of the sox1a:eGFP transgenic line identified the lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons. https://www.biorxiv.org/content/10.1101/2023.03.01.530240v1 #Morpholino

Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia. https://journals.asm.org/doi/10.1128/spectrum.04919-22
#Morpholino

YULINK regulates vascular formation in zebrafish and HUVECs. https://biolres.biomedcentral.com/articles/10.1186/s40659-023-00415-8 #Morpholino

In-Cell Penetration Selection–Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery. https://pubs.acs.org/doi/10.1021/acschembio.2c00920 #Morpholino

Mob4 is required for neurodevelopment in zebrafish. https://www.micropublication.org/journals/biology/micropub-biology-000762 #Morpholino

AMO (antisense morpholino oligo) disrupts U1 snRNP structure to promote intronic premature cleavage and polyadenylation (PCPA). https://www.biorxiv.org/content/10.1101/2023.02.24.529985v1 #Morpholino

Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish. https://www.pnas.org/doi/10.1073/pnas.2102569120 #Morpholino

Next steps for the optimization of exon therapy for Duchenne muscular dystrophy
Galina Filonova & Annemieke Aartsma-Rus
EXPERT OPINION ON BIOLOGICAL THERAPY. 2023;23(2): 133–43. doi:10.1080/14712598.2023.216907
https://www.tandfonline.com/doi/epdf/10.1080/14712598.2023.2169070

Alternative splicing of its 5’ untranslated region controls CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. https://www.biorxiv.org/content/10.1101/2023.02.19.529123v1 #Morpholino

Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. https://www.mdpi.com/2073-4409/12/4/666 #Morpholino

USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling. https://www.science.org/doi/10.1126/scisignal.abn8372 #Morpholino

FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. https://www.sciencedirect.com/science/article/abs/pii/S0006291X23002206 #Morpholino

TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. https://www.nature.com/articles/s41467-023-36277-7 #Morpholino

Neurogenin 2 and Neuronal Differentiation 1 Control Proper Development of the Chick Trigeminal Ganglion and Its Nerve Branches. https://www.mdpi.com/2221-3759/11/1/8 #Morpholino

Synthesis of Chlorophosphoramidate Monomer Morpholinos and PMOs. https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.686 #Morpholino

p16 INK4A drives non-alcoholic fatty liver disease phenotypes in high fat diet fed mice via biliary e2f1/foxo1/igf-1 signaling. https://journals.lww.com/hep/Abstract/9900/p16_INK4A_drives_non_alcoholic_fatty_liver_disease.303.aspx
#Morpholino

I'll halt #Morpholino toots for a week to go present at #PharmaR&D, 21 Feb - 23 Feb, Las Vegas, NV USA
Altering Eukaryotic Splicing with Morpholino Oligos: Drugging for Isoforms
08:40AM - 09:00AM Feb 22
https://unitedscientificgroup.com/conferences/pharma/