jonmoulton @jonmoulton@social.cleverlibre.org

Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length. https://pubs.acs.org/doi/10.1021/acs.est.2c09716 #Morpholino

BDNF signaling in correlation-dependent structural plasticity in the developing visual system. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002070 #Morpholino

Abnormal autophagy is a critical mechanism in TANGO2-related rhabdomyolysis. https://www.biorxiv.org/content/10.1101/2023.03.29.534583v1 #Morpholino

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. https://elifesciences.org/articles/83652 #Morpholino

Inhibition of Interferon Alpha by a Peptide-Conjugated Phosphorodiamidate #Morpholino Oligomer Increases Influenza Virus Replication in Chicken Embryo Fibroblast (DF-1) Cells; An Alternative Strategy to Increasing Vaccine Production in Cell Culture. https://ssrn.com/abstract=4057449

Her6 and Prox1 are novel regulators of photoreceptor regeneration in the zebrafish retina https://www.biorxiv.org/content/10.1101/2023.03.20.532714v1 #Morpholino

I'm guest editing a topic collection for Frontiers in Genetics (@FrontGenetics). Anyone have new #Morpholino gymnastics to offer?
Frontiers research topic: Steric-blocking Oligos Changing and Probing RNA Processes
https://www.frontiersin.org/research-topics/52581/steric-blocking-oligos-changing-and-probing-rna-processes

In Vivo Evaluation of Exon 51 Skipping in hDMD/Dmd-null Mice. https://link.springer.com/protocol/10.1007/978-1-0716-3036-5_23 #Morpholino

Exons 45–55 Skipping Using Antisense Oligonucleotides in Immortalized Human DMD Muscle Cells.
https://link.springer.com/protocol/10.1007/978-1-0716-3036-5_22 #Morpholino

Improved Prediction of Antisense Oligonucleotide Efficacy for Exon Skipping Using Ensemble Learning and Feature Selection. https://www.preprints.org/manuscript/202303.0389/v1 #Morpholino

ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo. https://www.embopress.org/doi/full/10.15252/emmm.202217157
#Morpholino

An overview of recent US-approved gene therapies for Duchenne muscular dystrophy and their respective clinical development programs. https://link.springer.com/article/10.1007/s40267-023-00986-2 Review with #Morpholino $SRPT

Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma. https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-023-01759-1 #Morpholino

Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish. https://www.nature.com/articles/s41467-023-37110-x #Morpholino

CLN3 deficiency leads to neurological and metabolic perturbations during early development. https://www.biorxiv.org/content/10.1101/2023.03.17.533107v1 #Morpholino

Self-transfecting GMO-PMO antisense chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00070-7 #Morpholino

Investigating the Impact of Delivery Routes for Exon Skipping Therapies in the CNS of DMD Mouse Models. Cells. https://www.mdpi.com/2073-4409/12/6/908 #Morpholino

Genetic mapping and molecular mechanism behind color variation in the Asian vine snake. https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-02887-z #Morpholino

Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway https://www.sciencedirect.com/science/article/abs/pii/S1050464823001584 #Morpholino

Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance. https://www.nature.com/articles/s41586-023-05767-5 #Morpholino