Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides. https://www.biorxiv.org/content/10.1101/2023.04.14.536849v1 #Morpholino
Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial. https://onlinelibrary.wiley.com/doi/abs/10.1002/npr2.12335 #Morpholino
Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. https://www.nature.com/articles/s41467-023-37745-w #Morpholino
TAR Syndrome-associated Rbm8a deficiency causes hematopoietic defects and attenuates Wnt/PCP signaling. https://www.biorxiv.org/content/10.1101/2023.04.12.536513v2 #Morpholino
Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999. https://www.nature.com/articles/s41467-023-37819-9 #Vivo-Morpholino
A Realistic Mixture of Persistent Organic Pollutants Affects Zebrafish Development, Behavior, and Specifically Eye Formation by Inhibiting the Condensin I Complex. https://www.mdpi.com/2305-6304/11/4/357 #Morpholino
Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue. https://onlinelibrary.wiley.com/doi/full/10.1002/jnr.25197 #Morpholino
Enhancement of zebrafish sperm production via a large body-sized surrogate with germ cell transplantation. https://www.nature.com/articles/s42003-023-04800-7 #Morpholino
miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury. https://journals.lww.com/hepcomm/Fulltext/2023/04010/miR_34a_regulates_macrophage_associated.41.aspx #Morpholino
Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy. https://www.nature.com/articles/s41467-023-37619-1 #Morpholino
Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. https://www.pnas.org/doi/10.1073/pnas.2214997120 #Morpholino
The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during Xenopus gastrulation. https://www.molbiolcell.org/doi/10.1091/mbc.E22-09-0411 #Morpholino
Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System.
https://www.mdpi.com/1422-0067/24/7/6804 #Morpholino
Long noncoding RNA HIKER regulates erythropoiesis in Monge’s disease via CSNK2B. https://www.jci.org/articles/view/165831 #Morpholino
Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00362-5 #Morpholino
Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. https://www.nature.com/articles/s41422-023-00797-0 #Morpholino
Characterization of regeneration initiating cells during Xenopus laevis tail regeneration. https://www.biorxiv.org/content/10.1101/2023.03.30.534908v1 #Morpholino
Colec12 and Trail signaling confine cranial neural crest cell trajectories and promote collective cell migration. https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.569 #Morpholino
Mutations in VWA8 cause autosomal-dominant retinitis pigmentosa via aberrant mitophagy activation. https://jmg.bmj.com/content/early/2023/04/02/jmg-2022-108888 #Morpholino
Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. https://www.mdpi.com/2079-7737/12/4/538 #Morpholino
It's been all Morpholinos all the time for about 23 years. I'm a scientist with Gene Tools LLC.