jonmoulton @jonmoulton@social.cleverlibre.org

In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. https://www.frontiersin.org/articles/10.3389/fendo.2023.1157685/full #Morpholino

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy. https://www.pnas.org/doi/10.1073/pnas.2220911120 #Morpholino

(Poster): Preclinical findings support the development of PYC-001
PYC-001, a peptide-conjugated phosphorodiamidate
morpholino oligomer for the treatment of autosomal
dominant optic atrophy
https://pyctx.com/wp-content/uploads/2023/05/20230424_ADOA-TIDES-Poster_FINAL-A4.pdf
preclinical peptide-#Morpholino (PPMO)

Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-023-03328-1 #Morpholino

mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations. https://www.biorxiv.org/content/10.1101/2023.04.24.538105v1 #Morpholino

Epigenetic landscape reveals MECOM as an endothelial lineage regulator. https://www.nature.com/articles/s41467-023-38002-w #Morpholino

PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma. https://www.sciencedirect.com/science/article/pii/S0006497122001471 Vivo-#Morpholino

Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. https://www.sciencedirect.com/science/article/abs/pii/S0006291X23005272 #Morpholino

Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. https://www.science.org/doi/10.1126/sciadv.ade0631 #Morpholino

Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression. https://journals.biologists.com/dev/article-abstract/doi/10.1242/dev.201460/308861/Voltage-gated-sodium-channel-activity-mediates-sea #Morpholino

BMP signaling is required to form the anterior neural plate border in ascidian embryos. https://link.springer.com/article/10.1007/s00427-023-00702-0 #Morpholino

The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus. https://www.life-science-alliance.org/content/6/7/e202302023 #Morpholino

Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. https://biolres.biomedcentral.com/articles/10.1186/s40659-023-00430-9 #Morpholino

Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway. https://www.discovmed.com/EN/10.24976/Discov.Med.202335175.15 #Morpholino

Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01599-x #Morpholino

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS. https://elifesciences.org/articles/85902 #Morpholino

The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. https://onlinelibrary.wiley.com/doi/10.1002/advs.202205345 #Morpholino

Upcoming Gene Tools exhibits:

Association for Research in Vision and Ophthalmology (ARVO), 23Apr-27Apr, New Orleans LA
Jon will be at ARVO in NOLA.

AAPS National Biotechnology Conference, 23Apr-26Apr, Philadelphia PA
It's Brandy's turn for Philadelphia.

#Morpholino

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation. https://www.nature.com/articles/s41467-023-37928-5 #Morpholino

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation. https://www.biorxiv.org/content/10.1101/2023.04.15.537039v1
#Morpholino