jonmoulton @jonmoulton@social.cleverlibre.org

Nerve-independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3. https://www.science.org/doi/10.1126/sciadv.adg0183 #Morpholino

Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism. https://pubs.acs.org/doi/10.1021/acschembio.3c00027 #Morpholino

Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200863/265709/Sfxn5-Regulation-of-Actin-Polymerization-for #Morpholino

Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs).
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad415/7177882
#Morpholino antibody conjugates

The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. https://www.sciencedirect.com/science/article/pii/S0753332223007424 #Morpholino

Plexina4 and cell survival in the developing zebrafish hindbrain. https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.633 #Morpholino

Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl. https://www.sciencedirect.com/science/article/abs/pii/S0012160623000945 #Morpholino

Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. https://www.frontiersin.org/articles/10.3389/fgene.2023.1186882/full #Morpholino

Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo. https://www.frontiersin.org/articles/10.3389/fnsyn.2023.1176864/full #Morpholino

The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs. https://www.jbc.org/article/S0021-9258(23)01882-3/fulltext #Morpholino

Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway. https://www.frontiersin.org/articles/10.3389/fcell.2023.1123299/full #Morpholino

Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in Duchenne muscular dystrophy. https://www.biorxiv.org/content/10.1101/2023.05.09.540042v1 #Morpholino

A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. https://humgenomics.biomedcentral.com/articles/10.1186/s40246-023-00491-7 #Morpholino

Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction. https://www.mdpi.com/2073-4409/12/9/1327 #Morpholino

The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish. https://www.sciencedirect.com/science/article/abs/pii/S0091679X22002072 #Morpholino

Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish Thrombopoiesis. https://www.researchsquare.com/article/rs-2807790/v1 #Morpholino

Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor. https://elifesciences.org/articles/84036 #Morpholino

Efficacy and Safety of Viltolarsen in Boys With Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study. https://content.iospress.com/articles/journal-of-neuromuscular-diseases/jnd221656
#Morpholino

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. https://www.biorxiv.org/content/10.1101/2023.05.04.539492v1
#Morpholino

The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation. https://www.nature.com/articles/s41422-023-00811-5 #Morpholino