jonmoulton @jonmoulton@social.cleverlibre.org

Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010873 #Morpholino

#Morpholino blog from Biobide
https://blog.biobide.com/morpholino-and-zebrafish-benefits-and-applications

[Prickle planar cell polarity protein 1 involved in the pathogenesis of skeletal class Ⅲ malocclusion]. https://rs.yiigle.com/cmaid/1468270 #Morpholino

Deletion of miR-146a enhances therapeutic protein restoration in model of dystrophin exon skipping. https://www.biorxiv.org/content/10.1101/2023.05.09.540042v2 #Morpholino

Neuronal migration prevents spatial competition in retinal morphogenesis. https://www.nature.com/articles/s41586-023-06392-y #Morpholino

Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos. https://www.nature.com/articles/s41467-023-40496-3 #Morpholino

An integeative GWAS followed by functional investigation reveals possible involvement of CNTNAP5 in glaucomatous neurodegeneration. https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.15896 #Morpholino

Ribo-On and Ribo-Off tools using a self-cleaving ribozyme allow manipulation of endogenous gene expression in C. elegans. https://www.nature.com/articles/s42003-023-05184-4 Vivo-#Morpholino

The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00172-5 #Morpholino

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach. https://www.nature.com/articles/s41598-023-38698-2 #Morpholino

Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans. https://www.science.org/doi/10.1126/scitranslmed.adf2059 Vivo-#Morpholino

Aicardi Syndrome Is a Genetically Heterogeneous Disorder. https://www.mdpi.com/2073-4425/14/8/1565 #Morpholino

Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development. https://www.frontiersin.org/articles/10.3389/fcell.2023.1168643/full #Morpholino

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth. https://www.nature.com/articles/s41388-023-02793-5 #Morpholino

mRNA location and translation rate determine protein targeting to dual destinations. https://www.sciencedirect.com/science/article/pii/S1097276523005142 #Morpholino

Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping. https://www.mdpi.com/1999-4923/15/7/1808 #Morpholino

HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. https://www.pnas.org/doi/10.1073/pnas.2221522120 #Morpholino

Non-canonical function of folate/folate receptor 1 during neural tube formation. https://www.biorxiv.org/content/10.1101/2023.07.19.549718v1 #Morpholino and Vivo-#Morpholino

Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1. https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(23)00307-6 #Morpholino

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium. https://www.nature.com/articles/s41556-023-01187-9 #Morpholino