β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus. https://www.mdpi.com/1422-0067/24/17/13593 #Morpholino
Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos. https://www.sciencedirect.com/science/article/abs/pii/S0892036223001411 #Morpholino
Alternative splicing of its 5' UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. https://ashpublications.org/blood/article/doi/10.1182/blood.2023020400/497824/Alternative-splicing-of-its-5-UTR-limits-CD20-mRNA #Morpholino
An ancient pan-cnidarian microRNA regulates stinging capsule biogenesis in Nematostella vectensis. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01083-5 #Morpholino
Actomyosin remodeling regulates biomineral formation, growth and morphology during eukaryote skeletogenesis. https://elifesciences.org/reviewed-preprints/89080 #Morpholino
Inhibition of the serine protease HtrA1 by SerpinE2 suggests a role for an extracellular proteolytic pathway in the control of neural crest migration. https://www.biorxiv.org/content/10.1101/2023.09.05.556243v1 #Morpholino
Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus. https://www.cell.com/developmental-cell/pdf/S1534-5807(23)00411-2.pdf #Morpholino
(student presentation): Exploring How Splice Site Silencing Impacts Gene Transcription (second abstract, Simrah Bawa) https://www.bu.edu/lernet/grow/participants/abstracts2023.html (video) https://youtu.be/irJxcOJMHLg #Morpholino
Live imaging studies reveal how microclots and the associated inflammatory response enhance cancer cell extravasation. https://journals.biologists.com/jcs/article/doi/10.1242/jcs.261225/327618/Live-imaging-studies-reveal-how-microclots-and-the #Morpholino
Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. https://www.preprints.org/manuscript/202309.0215/v1 #Morpholino
The gastropod Lottia peitaihoensis as a model to study the body patterning of trochophore larvae. https://onlinelibrary.wiley.com/doi/10.1111/ede.12456 #Morpholino
Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish. https://www.nature.com/articles/s41467-023-41114-y #Morpholino
Characterization of Msantd4 Gene in the Development of Xenopus Laevis. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4559111 #Morpholino
Endosomal Escape Vehicle–Oligonucleotide Conjugates for the Targeted Upregulation and
Downregulation of Gene Expression. https://entradatx.com/documents/presentations/entrada_streeter_eev-pmo-to-up-&-downregulate-gene-expression_aps-2023.pdf #Morpholino
Disruption of fos causes craniofacial anomalies in developing zebrafish. https://www.frontiersin.org/articles/10.3389/fcell.2023.1141893/full #Morpholino
DMD antisense oligonucleotide mediated exon skipping efficiency correlates with flanking intron retention time and target position within the exon. https://www.tandfonline.com/doi/full/10.1080/15476286.2023.2254041 #Morpholino
Apical size and deltaA expression predict adult neural stem cell decisions along lineage progression. https://www.science.org/doi/10.1126/sciadv.adg7519 #Morpholino
Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development. https://www.mdpi.com/1422-0067/24/17/13578 #Morpholino
YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwad227/7252931 #Morpholino
Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain. https://journals.biologists.com/dev/article/doi/10.1242/dev.201319/326583/Zbtb16-mediates-a-switch-between-Fgf-signalling #Morpholino
It's been all Morpholinos all the time for about 23 years. I'm a scientist with Gene Tools LLC.