jonmoulton @jonmoulton@social.cleverlibre.org

Purine Biosynthesis Pathways Are Required for Myogenesis in Xenopus laevis. https://www.mdpi.com/2073-4409/12/19/2379 #Morpholino

A digital twin reproducing gene regulatory network dynamics of early Ciona embryos indicates robust buffers in the network. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010953 #Morpholino

Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension. https://elifesciences.org/reviewed-preprints/91199v1 #Morpholino

A bioelectrical phase transition patterns the first vertebrate heartbeats. https://www.nature.com/articles/s41586-023-06561-z #Morpholino

Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression. https://www.mdpi.com/2073-4409/12/18/2309 #Morpholino

Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes. https://www.mdpi.com/1422-0067/24/18/14324 #Morpholino

Hand2 represses non-cardiac cell fates through chromatin remodeling at cis-regulatory elements. https://www.biorxiv.org/content/10.1101/2023.09.23.559156v1 #Morpholino

Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01288-w #Morpholino

Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis. https://www.nature.com/articles/s41598-023-42868-7 #Morpholino

Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential. https://www.nature.com/articles/s41467-023-41384-6 #Morpholino

Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00252-4 #Morpholino

Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit. https://elifesciences.org/reviewed-preprints/91258 #Morpholino

Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00237-8 #Morpholino

SASH1 contributes to glial cell migration in the early development of the central nervous system. https://www.sciencedirect.com/science/article/abs/pii/S0012160623001604 #Morpholino

No more #Morpholino tweets for the rest of this week. I am headed for the NIH Research Festival in Bethesda.

Myosin1G promotes Nodal signaling to control Zebrafish Left-Right asymmetry. https://www.biorxiv.org/content/10.1101/2023.09.15.557992v1 #Morpholino

Transposable elements drive the evolution of metazoan zinc finger genes. https://genome.cshlp.org/content/early/2023/09/15/gr.277966.123 #Morpholino

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation. https://www.mdpi.com/2073-4409/12/18/2285 #Morpholino

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain. https://www.nature.com/articles/s41598-023-41240-z #Morpholino

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. https://elifesciences.org/articles/58300 #Morpholino