jonmoulton @jonmoulton@social.cleverlibre.org

Two novel CHN1 variants identified in Duane retraction syndrome pedigrees disrupt development of ocular motor nerves in zebrafish. https://www.nature.com/articles/s10038-023-01201-w #Morpholino

Ciliary localization of a light-activated neuronal GPCR shapes behavior. https://www.pnas.org/doi/10.1073/pnas.2311131120 #Morpholino

A novel role for the chloride intracellular channel protein Clic5 in ciliary function. https://www.nature.com/articles/s41598-023-44235-y #Morpholino

Chemist 1 position. https://www.indeed.com/viewjob?jk=e1b978a0f97b5cf0 #Morpholino

Xbra modulates the activity of linker region phosporlated Smad1 during Xenopus somitogenesis. https://www.biorxiv.org/content/10.1101/2023.10.11.561863v1 #Morpholino

Rtf1-dependent transcriptional pausing regulates cardiogenesis. https://www.biorxiv.org/content/10.1101/2023.10.13.562296v1 #Morpholino

(Dissertation): Developing technologies to produce reproductively sterile finfish and oysters, and characterizing changes of gene expression in the pituitary of sterile fish by single-cell RNA sequencing. https://mdsoar.org/handle/11603/27320 #Morpholino

Synthesis and Biophysical Studies of High-Affinity #Morpholino Oligomers Containing G-Clamp Analogs. https://pubs.acs.org/doi/10.1021/acs.joc.3c01658

P45 A phase 1/2 study of DYNE-251 in males with DMD mutations amenable to exon 51 skipping: DELIVER study design. https://www.nmd-journal.com/article/S0960-8966(23)00206-7/pdf #Morpholino

Crb3 is required to organize the apical domain of multiciliated cells. https://journals.biologists.com/jcs/article-abstract/doi/10.1242/jcs.261046/333513/Crb3-is-required-to-organize-the-apical-domain-of #Morpholino

Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors. https://onlinelibrary.wiley.com/doi/10.1002/mabi.202300375 #Morpholino

Chaperone-mediated autophagy protects against hyperglycemic stress. https://www.tandfonline.com/doi/figure/10.1080/15548627.2023.2267415 #Morpholino

Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification. https://link.springer.com/article/10.1007/s00018-023-04933-2 #Morpholino

An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. https://www.biorxiv.org/content/10.1101/2023.10.05.561099v2 #Morpholino

P29 DMD transcript imbalance and nuclear trafficking evaluation in muscle biopsies from baseline and golodirsen treated 4053-101 clinical trial patients. https://www.nmd-journal.com/article/S0960-8966(23)00336-X/pdf #Morpholino

P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model. https://www.nmd-journal.com/article/S0960-8966(23)00330-9/pdf #Morpholino

SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells. https://academic.oup.com/jes/article/7/Supplement_1/bvad114.933/7290239 #Morpholino

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. https://www.nature.com/articles/s41467-023-41836-z #Morpholino

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation. https://www.nature.com/articles/s41598-023-43662-1 #Morpholino

(Video): New Exon Skipping Drug in Clinical Development for Duchenne Muscular Dystrophy: Steve Hughes, MD, chief medical officer at AvidityBiosciences https://www.youtube.com/watch?v=XV56y_bwBZM PMO are #Morpholino