mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide–PMO Conjugates. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.3c00408 #Morpholino
Induction of Reproductive Sterility in Coho Salmon (Oncorhynchus kisutch) by an Immersion-Based Gene Silencing Technology. https://www.mdpi.com/2077-1312/11/12/2208 Vivo-#Morpholino
UGT1A1 morpholino antisense oligonucleotides produce mild unconjugated hyperbilirubinemia in cyclosprin A-induced cardiovascular disorders in BLC57 mice. https://www.sciencedirect.com/science/article/abs/pii/S1382668923002636 #Morpholino
Embryo-scale reverse genetics at single-cell resolution. https://www.nature.com/articles/s41586-023-06720-2 #Morpholino
asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. https://www.mdpi.com/1422-0067/24/22/16364 #Morpholino
Combined RhoA Morpholino and ChABC Treatment Protects Identified Lamprey Neurons from Retrograde Apoptosis after Spinal Cord Injury. https://www.frontiersin.org/articles/10.3389/fncel.2023.1292012/abstract #Morpholino
Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. https://link.springer.com/article/10.1007/s13346-023-01469-7 #Morpholino
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice. https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-023-00331-1
#Morpholino
Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects. https://www.biorxiv.org/content/10.1101/2023.11.09.566412v1 #Morpholino
Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation. https://www.biorxiv.org/content/10.1101/2023.11.07.566007v1 #Morpholino
IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01349-0 #Morpholino
The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation. https://www.biorxiv.org/content/10.1101/2023.11.08.566201v1 #Morpholino
Optimization and Safety Results of E1v1.11: a #Morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy
https://www.mdaconference.org/abstract-library/optimization-and-safety-results-of-e1v1-11-a-morpholino-antisense-oligonucleotide-therapeutic-for-spinal-muscular-atrophy/
Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration. https://www.nature.com/articles/s41467-023-42929-5 #Morpholino
Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve Circulation. https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.14239 #Morpholino
Kif21a deficiency leads to impaired glomerular filtration barrier function. https://www.nature.com/articles/s41598-023-46270-1 #Morpholino
Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011010 #Morpholino
The zebrafish paralog six2b is required for early proximal pronephros morphogenesis. https://www.nature.com/articles/s41598-023-47046-3 #Morpholino
Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling. https://www.biorxiv.org/content/10.1101/2023.10.30.563773v1 #Morpholino
Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. https://www.science.org/doi/10.1126/sciadv.adi4777 #Morpholino
It's been all Morpholinos all the time for about 23 years. I'm a scientist with Gene Tools LLC.