jonmoulton @jonmoulton@social.cleverlibre.org

R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient. https://www.nature.com/articles/s41467-024-44951-7 #Morpholino

Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis. https://www.frontiersin.org/articles/10.3389/fcell.2024.1316048/abstract #Morpholino

Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino. https://www.sciencedirect.com/science/article/abs/pii/S0091679X22001455 Vivo-#Morpholino

Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina. https://journals.biologists.com/dev/article-abstract/151/2/dev201463/342422/Awakening-adult-neural-stem-cells-NOX-signalling #Morpholino

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. https://ehoonline.biomedcentral.com/articles/10.1186/s40164-023-00468-1
#Morpholino

Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development. https://www.biorxiv.org/content/10.1101/2024.01.26.577434v1 #Morpholino

Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease. https://preprints.org/manuscript/202401.1959/v1 #Morpholino

Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing. https://www.nature.com/articles/s41598-024-52530-5 #Morpholino

A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish. https://www.sciencedirect.com/science/article/abs/pii/S0006291X2400086X #Morpholino

Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. https://doi.org/10.1101/2024.01.25.576046 #Morpholino

Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice. https://www.biorxiv.org/content/10.1101/2024.01.24.577012v1 #Morpholino

Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae. https://www.sciencedirect.com/science/article/pii/S0012160624000010 #Morpholino

An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo. https://journals.physiology.org/doi/abs/10.1152/ajpheart.00745.2023 Vivo-#Morpholino

Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. https://www.mdpi.com/2073-4409/13/3/214 #Morpholino

TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish. https://www.frontiersin.org/articles/10.3389/fncel.2024.1340240/abstract #Morpholino

Deficiency of copper responsive gene stmn4 induces retinal developmental defects. https://link.springer.com/article/10.1007/s10565-024-09847-8 #Morpholino

The Effect of Morpholino Oligonucleotides to Gene Anxa2a on the Embryonic Development of Danio rerio. https://link.springer.com/article/10.3103/S0891416823030059 #Morpholino

When I tweet #Morpholino citations, they are also going into our searchable online database. You can access citations & abstracts of over 12,000 papers at pubs.gene-tools.com

Epileptic phenotypes in slc13a5 loss-of-function zebrafish are rescued by blocking NMDA receptor signaling. https://www.biorxiv.org/content/10.1101/2024.01.15.575806v1 #Morpholino

Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. https://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2023.032 #Morpholino