Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
RT @RealTimeCOVID19
NIH study: a history of MIS-C is NOT associated with increased risk of serious adverse reactions following COVID-19 vaccination #pediatrics #vaccinesafety https://twitter.com/nih_nhlbi/status/1610328538569129985
Thiago Carvalho
boosted
New article! Read Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants https://www.nature.com/articles/s41541-022-00586-7?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines
"The results demonstrate that the hamster model reliably phenocopies indicators of a dysregulated alveolar regeneration of COVID-19 patients. The study provides a suitable translational model for future research on the pathomechanims of PASC and testing of prophylactic and therapeutical approaches."
"Our results suggest that, in a cellular context, Fab glycans inhibit IgG–hFcRn interaction and thus negatively affect the transplacental transfer of IgG. As Fab-glycosylated Abs are frequently associated with autoimmune and malignant disorders and may be potentially harmful, this might encompass a regulatory mechanism, limiting the half-life and transport of such Abs."
Thiago Carvalho
boosted
We've had some great long-form #interviews with active research scientists on topics like #preprint distribution, #openscience and science #publishing on The Commons - the Review Commons #blog - including:
Mark Hanson https://www.reviewcommons.org/blog/models-oddballs-and-preprints-a-conversation-with-mark-hanson/
Caren Norden https://www.reviewcommons.org/blog/i-believe-in-the-peer-review-process-a-conversation-with-caren-norden/
Marco Trizzino https://www.reviewcommons.org/blog/i-think-review-commons-is-the-future-an-interview-with-review-commons-author-marco-trizzino/
@MA_macedo Isto e' resposta a algum comentário em Portugal sobre o Lula? Poderia me dizer de quem (com link se tiver), por favor?
Thiago Carvalho
boosted
Nice summary by Ken Zaret of our (@joadelas@twitter.com) recent work investigating the genomic mechanisms interpreting SHH morphogen signaling in the neural tube
Two ways to skin a new cell fate https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00846-2#.Y716CdxYzO8.twitter
Thiago Carvalho
boosted
Meet the first Black American to earn an evolutionary biology Ph.D.
https://sciencenews.org/article/first-black-american-evolutionary-biology-phd
Joseph L. Graves Jr. offers a memoir and more in ‘A Voice in the Wilderness’
'As E. B. White wrote in a collection of his own correspondence (edited by Dotty, who was his goddaughter), “A man who publishes his letters becomes a nudist—nothing shields him from the world’s gaze except his bare skin,” and if we know anything about Salinger it’s that he would not have liked that.'
https://www.newyorker.com/culture/comma-queen/the-editor-who-edited-salinger
"On 6 January 2021, Bolsonaro – now known as ‘Captain Fugitive’ by his disappointed supporters – tweeted that the invasion of the US Congress was small potatoes compared to what he would have in store for Brazil should he lose the elections in 2022. For once, he appears to have been telling the truth, since the mob in the Praça dos Três Poderes was much larger than the one in DC, and wreaked greater destruction on the physical infrastructure of the federal government."
https://www.lrb.co.uk/blog/2023/january/chronicle-of-a-coup-foretold
Thiago Carvalho
boosted
Yes, the explosive period of the #mpox outbreak has been quelled. But the global footprint of the virus is now bigger than it was before. And as attention on mpox wanes, cases could go undetected & unreported. https://www.statnews.com/2023/01/10/health-officials-fear-mpox-infections-will-go-undetected-unreported/
Thiago Carvalho
boosted
@cyrilpedia I love this section: "How did ‘endemic’ — the term used in infectious disease to describe our relentless struggle in the relationship with our greatest scourges of HIV, tuberculosis and malaria — come to be re-appropriated to mean some form of victory over COVID-19? If we now meet the COVID challenge poorly and throw in the towel, historians may puzzle over our ineptitude for centuries to come."
Thiago Carvalho
boosted
"...we now again face segregation into rival tribes: the short attention spans, COVID-19 revisionism and ‘move along, there’s nothing to see here’ attitude of our global leaders threatens the laser focus that the scientists will need if we are to avoid endemic bedding-in of massively elevated mortality along with a lasting worldwide burden of disability imposed by more than 150 million cases of long COVID. "
Brilliant stuff from Daniel Altmann. #COVID H/T @cyrilpedia
"All mammals have platelets, which are necessary for survival because they arrest bleeding (haemostasis). No other order has platelets, even though the problem of bleeding exists. A solution to the enigma of why only mammals have platelets was recently proposed, linking the origin of the platelet in an egg-laying animal, which initially did not have platelets, to the evolution of the eutherian (haemochorial) placenta found in all mammals apart from monotremes and marsupials"
"The SARS-CoV-2 immunology dataset rapidly overtook our knowledge of most other human pathogens that had been studied for decades. Yet, lest we sink into self-congratulatory immunological hubris, there are huge and self-evident caveats to our pride in these achievements."
'Between 1995 and 2016, the number of independent bookshop members in the BA dropped from 1,894 to 867 as the industry faced stiff competition from Amazon and financial pressures from business rate hikes. However, with the ongoing resurgence that figure reached 1,072 in 2022, a net increase of 45 on the tally of 1,027 for 2021.'
"To extend the current knowledge on maternal microchimerism functions to their postnatal immune roles, we implemented an approach to deplete maternal cells in the neonates by diphtheria toxin (DT) injection and compared the spleens’ immune profiles of the 2-week-old pups with intact and depleted maternal cells by mass cytometry immunophenotyping."
Thiago Carvalho
boosted
It's great to see the Cdc42 biosensor that we optimized has been used to detect active Cdc42 near invadopodia. Find all of the details in the publication coordinated by Rafael Garcia-Mata : https://rupress.org/jcb/article/22
"he mutational signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers. However, data linking individual APOBEC3 proteins to cancer mutagenesis in vivo are limited. Here, we showed that transgenic expression of human APOBEC3G promotes mutagenesis, genomic instability, and kataegis, leading to shorter survival in a murine bladder cancer model."
'Gene duplication and diversification allow hosts to mutate otherwise essential genes, whereas changes in transcriptional regulation can selectively activate genes should their constitutive expression be detrimental. To counter mutational tolerance, it has been suggested that viruses target essential genes as host cofactors, because the genes are less prone to variability'
#Virology #HostPathogen #RNASplicing
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001934
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
