Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Thiago Carvalho
boosted
April 4, 2021, microbiologist Thomas Brock died #OTD at the age of 94. His discovery of thermophile bacteria at #Yellowstone in 1966 revolutionized biology & eventually allowed the development of tests for DNA & #COVID-19 🌋🦠
"Whether perturbations of any of these endosome-related processes can give rise to TLR7 gain-of-function and facilitate self-reactivity has not been investigated. Here, we show that a dysregulated endosomal compartment leads to unrestricted TLR7 signaling and human lupus."
#Preprint #Immunology #InnateImmunity #Lupus #TollLikeReceptor
"Understanding the mechanisms that maintain the endothelial barrier in the context of pathological stressors is the first step toward the development of new therapeutic approaches for retinopathies."
Thiago Carvalho
boosted
RT @ElizSMcKenna
In the April issue of @CD_AACR - a new review by @hamieh @JorgeMansilla_S Isabelle Rivière & @Michel_Sadelain @MSKCancerCenter: Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating https://aacrjournals.org/cancerdiscovery/article/13/4/829/724992/Programming-CAR-T-Cell-Tumor-Recognition-Tuned #immunotherapy
Opportunity for pathogen genomics folks from Africa (African Union Member States):
"The program is open to National public health institutes (NPHIs) and National Reference Laboratories (NRLs) personnel who wish to gain experience in NGS sequencing or analyzing pathogen genomic sequence data. Applicants should have a minimum of BSc degree and be a citizen of the African Union Member States."
Thiago Carvalho
boosted
'Fungal epidemics in humans are infrequent, in part because human-to-human transmission of fungi is rare, and I am not aware of any involving zombielike creatures. It’s far more likely that the next pandemic will come from a virus. But the idea that climate change is making the emergence of new health threats more likely is solid. Could it cause a fungus ubiquitous in the environment to morph into a lethal pathogen in humans? It’s possible.'
https://www.nytimes.com/2023/04/02/opinion/the-last-of-us-fungus-climate-change.html
Thiago Carvalho
boosted
Thiago Carvalho
boosted
'Ben Barres Early Career Acceleration Awards. This is an investigator award for early career academic investigators, especially those who are new to the field of neurodegeneration. Awards are $1.2M in total costs over 4 years. Early career investigators will benefit from mentored support and resources of the CZI Neurodegeneration Challenge Network.'
https://chanzuckerberg.com/rfa/ben-barres-early-career-acceleration-awards/
Thiago Carvalho
boosted
RT @BrimacombeChris
Use caution when reusing ecological networks! Our new paper at @PLOSBiology shows that open species interaction networks are very structurally heterogenous, with those coming from different publications exhibiting the greatest heterogeneity. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002068
'In 2025 we will be continuing our efforts to diversify our Workshop programme so that we are able to support a wider selection of research communities around the world.
We will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.'
https://www.biologists.com/workshops/propose-new-workshop/#global_south
Thiago Carvalho
boosted
Career option reading. @preLights interviewed me about my career in sci comm.
Worth taking a look if you are a PhD or post-doc seeking to do something else or a PI interested in career choices your trainees can make.
https://prelights.biologists.com/news/prelights-talks-to-richard-sever/
There's also this piece we wrote a while ago on career options in general
https://cshperspectives.cshlp.org/content/9/9/a032755.full
which appeared in this book/collection
https://cshperspectives.cshlp.org/site/misc/career_options_for_biomedical_scientists.xhtml
Thiago Carvalho
boosted
@preLights We also discuss the development of biorxiv a bit.
Folks interested in learning more about the history of biorxiv should check out this video with @PracheeAC and Leonid Kruglyak
https://youtu.be/7YyBnaXpy08
'UK curator, gallerist and video essayist James Payne details how a combination of geopolitical and personal struggles led Goya to the bleak outlook that birthed these intense and often disturbing images, as well as the indelible influence they’ve had on art in the centuries since his death.'
https://aeon.co/videos/tracing-goyas-dark-journey-from-spanish-court-painter-to-macabre-visionary
Thiago Carvalho
boosted
The most promising drug against Alzheimer's shrinks the brains of patients
https://elpais-com.translate.goog/ciencia/2023-04-04/el-farmaco-mas-prometedor-contra-el-alzheimer-encoge-el-cerebro-de-los-pacientes.html?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp
T2 Phage by Madalena Parreira, a drawing for a piece I did on the Hershey-Chase experiments when I was at J Exp Med (for the short-lived JEM blog).
Thiago Carvalho
boosted
#Stemcell islets for the study and treatment of #diabetes: Join the upcoming lecture by our scientific director Maike Sander (@msanderlab)!
📆 April 6, 3 p.m.
💻 online event @ChariteBerlin
Register 👉 https://www.mdc-berlin.de/news/events/maike-sander-stem-cell-islets-study-and-treatment-diabetes
Thiago Carvalho
boosted
RT @ThiruKanneganti
We had the opportunity to write this piece on how our understanding of innate #immune sensing and cell death has grown and will continue to expand to improve therapeutic targeting. Thank you for covering this important topic @PLOSBiology! @StJudeResearch https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002022
'Tessa wants to share her research to inspire other scientists whose burning scientific questions in new model organisms also require technological developments to answer them. To that end, she created Cuttlebase, a website that chronicles the scientific tools her team has developed, including a 3D brain atlas and a staging series of dwarf cuttlefish embryonic development.'
https://thenode.biologists.com/if-you-give-a-scientist-a-cuttlefish/research/
STING maintains cells with metastatic potential in a dormant state in a mouse LUAD model.
#Immunology #TumorImmunology #CancerImmunity
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
