Thiago Carvalho @cyrilpedia@social.cleverlibre.org

A walking germinal center:

"A hyper-immune human subject was identified with a documented 18-year history of 756 immunizations to venoms spanning 2001 to 2018."
(ht @victoralab)

https://www.biorxiv.org/content/10.1101/2022.09.26.507364v2

My latest Clinical Pipeline column for #NatureMedicine, on fitusiran, a small interfering RNA for the treatment of hemophilia A or B. It may be particularly useful for patients with inhibitors (antibodies against clotting factors).

#drugdevelopment #drugdiscovery #SciComm #sciencecommunication #pharma #hemophilia 👇

https://www.nature.com/articles/d41591-023-00037-3

Very good news.

"The EU is planning a compulsory licensing system to allow it to take control of the manufacture of drugs and vaccines during a public health emergency, despite calls from pharmaceutical groups to protect patents"

https://www.ft.com/content/b777f019-ff02-41c3-8645-3d06e865f7fd

'Under pressure from their government, Chinese scientists have withheld data, withdrawn genetic sequences from public databases and altered crucial details in journal submissions. Western journal editors enabled those efforts by agreeing to those edits or withdrawing papers for murky reasons, a review by The Times of over a dozen retracted papers found.'

https://www.nytimes.com/2023/04/23/world/europe/chinese-censorship-covid.html

'Cancers that pass from one host to another are rare in nature, but can have devastating effects, says study co-author Rodrigo Hamede, a disease ecologist at the University of Tasmania in Hobart. “In a matter of 10 years, we lost between 60–70% of the overall [devil] population,” he says.'

https://www.nature.com/articles/d41586-023-01349-7

"Yet officials with the National Academies have kept quiet about one thing: their decision to accept roughly $19 million in donations from members of the Sackler family, the owners of Purdue Pharma, the maker of the drug OxyContin that is notorious for fueling the opioid epidemic."
cc @mucida

https://www.nytimes.com/2023/04/23/health/sacklers-opioids-national-academies-science.html

@lzvolk "A solid lid isn’t a perfect deterrent. I’ve been using one for years, and still the fruit flies hover, as if waiting for me to lapse. So I recently added one final hack, per experts’ advice, and diluted the produce in my bin with some used paper towels and shredded news clips."

@lzvolk Here are most of them, if that helps with the identification. They stopped laying eggs during the winter, but when spring came, it was a bonanza.

@lzvolk I wish I knew! We just got them at the local farmer's fair (also there are three ducks in the mix, so that amps up the diversity - and the eggs are delicious, with giant yolks).

'Não repara quem está distraído: a extrema-direita em barda recorre aos tribunais para processar ativistas, políticos e quem se destaca no espaço público em defesa do antirracismo, da igualdade, do combate à desigualdade e do progressismo.'

https://www.publico.pt/2023/04/24/opiniao/opiniao/obrigada-francisca-van-dunem-2047212

Frogs, glazed #stoneware by @hunchbacksociety

#ceramics #ceramicart #handmade #artgallery #artmastodon

https://madalenaparreira.com/Hunchbacksociety

"Transplantation of hNSCs has been shown to increase the number of CD4+CD25+Foxp3+ T regulatory cells (Tregs) in the spinal cords of murine models of MS, which is correlated with a strong localized remyelination response. However, the mechanisms by which hNSC transplantation leads to an increase in Tregs in the CNS remains unclear."

#immunology #Neuroimmunology

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200798/263631/Presentation-of-Human-Neural-Stem-Cell-Antigens?redirectedFrom=fulltext

'To appreciate this catastrophe, we’ve got to move the focus off humans, at least for a bit. H5N1 is devastating the world’s birds. Eagles are dropping dead, as are great horned owls and peregrine falcons and pelicans. Twenty California condors recently died of what’s suspected to be avian flu — 10 are confirmed so far. It’s the worst thing that has happened to wild birds since the pesticide DDT.'

https://www.nytimes.com/2023/04/23/opinion/bird-flu.html

From LinkedIn:

Are you ready for the opportunity to join one of EMBL's research groups across our six sites in Europe? 🧐 Then you're in luck, because the EMBL Sabbatical Visitor Fellowships are offering up to 15,000 Euros for external scientists to come join EMBL for three to six months 🥳

This fellowship is open to all PIs, independent scientists, research team leaders, and technical experts no matter the country of origin 👩🏽‍🔬 🌍

➡️ Want to find out more on how to receive the fellowship? Take a look here:

https://lnkd.in/eXpaUe5x