"We report the genome assembly of a female Late Pleistocene woolly mammoth (Mammuthus primigenius) with twenty-eight chromosome-length scaffolds, generated using mammoth skin preserved in permafrost for roughly 52,000 years."
@terriblemaps It's lovely out on Daydream Beach
Cell surface glycoproteomics: deciphering glycoproteins through a unique analytical capture approach | https://pubs.rsc.org/en/content/articlelanding/2023/AY/D3AY00982C #proteomics
"In a controversial move, Australia will become the world’s first country to allow the drugs psilocybin and MDMA to be prescribed by doctors to treat psychiatric conditions including depression and post-traumatic stress disorder. But many scientists are concerned that research has not yet conclusively shown that these drugs are safe or effective. And some clinicians fear that the regulation that will govern access to the drugs is insufficient."
If you're looking for a weekend podcast, here's a very interesting episode of Knowable on the placebo effect.
#SciComm #PlaceboEffect #drugdevelopment
"The study of Popova et al. highlights the importance of using human cell-based models to better understand the pathophysiological mechanisms of congenital rubella syndrome. It remains to be seen why and how the rubella virus specifically attacks microglia, and what its molecular targets are. Identifying the molecular cues released by other brain cells, which potentially increase infection, will be necessary to eventually develop therapies against congenital rubella syndrome."
#Immunology #Virology
For Throwback Thursday, an episode of the @EMBO Podcast on the clinical use of #phage to treat antibiotic resistant bacterial infection - with a brief stop at the Siege of Leningrad.
Featuring pediatric infectious disease physician Ameneh Khatami, historian Dmitriy Myelnikov, and Jessica Sacher of Phage Directory.
#EMBOPodcast #SciComm #PhageTherapy #Phage #antibioticresistance #sciencepodcast
Kurt M. Fraser Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala
https://www.biorxiv.org/content/10.1101/2023.06.28.546936v1.full.pdf
At last! New data show that SARS-CoV-2 (Omicron in particular) preferentially infects blood group A cells. Receptor binding domain (RBD) of SARS-CoV-2 shows similarity to several galectins and binds better to ACE2 with A blood group antigen. https://tinyurl.com/47w7rumu
Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria | https://www.nature.com/articles/s41467-023-39485-3 #proteomics
Postdoctoral Associate
UCLA
See the full job description on jobRxiv: https://jobrxiv.org/job/ucla-27778-postdoctoral-associate/?feed_id=48845
#ScienceJobs #hiring #research
Los Angeles #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/ucla-27778-postdoctoral-associate/?feed_id=48845
Very interesting piece by Vassilis Galanos on the use of #ai in higher #education #teaching
I recently heard Vassilis talking about this, and it gave me a lot to think about!
🤖 🤖 🤖 🤖 🤖
Why do these male leaf-cutter bees tuck their forelimbs under the thorax when resting? There were several other males, all kicking each other out of the flower patch.
Megachile sp. http://www.inaturalist.org/observations/170168032
#Pembroke1347 #iNaturalist #entomology #Hymenoptera #nativebees #insects
"The study of Popova et al. highlights the importance of using human cell-based models to better understand the pathophysiological mechanisms of congenital rubella syndrome. It remains to be seen why and how the rubella virus specifically attacks microglia, and what its molecular targets are. Identifying the molecular cues released by other brain cells, which potentially increase infection, will be necessary to eventually develop therapies against congenital rubella syndrome."
#Immunology #Virology
Meanwhile, at the Bad Place
'The former NBCUniversal advertising head, who started as chief executive on June 5, is seeking to launch full-screen, sound-on video ads that would be shown to users scrolling through Twitter’s new short-video feed, according to three people familiar with the situation.'
https://www.ft.com/content/5a792427-5ca0-48f8-a459-c704036d1d35
Foundational and I'd say still unsurpassed as a history of the birth of molecular biology.
'Around that time, the late 1970s and very early 1980s, I became much more interested in nonfiction, especially nonfiction about science, and found myself reviewing such books for The Christian Science Monitor: the letters of Robert Oppenheimer, for instance, and a book of memoirs by Carl Friedrich von Weizsäcker, and a magnificent book (more magnificent than I was capable of appreciating then) on the foundational history of molecular biology, The Eighth Day of Creation, by Horace Freeland Judson.'
https://www.nybooks.com/online/2023/06/24/who-swims-with-the-scientist-david-quammen/
'La inmensa mayoría de los físicos e ingenieros que participaron en el proyecto Manhattan eran pacifistas, progresistas y ninguno creía que la bomba se fuera a lanzar contra la población civil. Algunos de ellos, cuando entrevieron las intenciones de los militares y el presidente Truman, pagaron su oposición con algo más que represalias.'
https://elpais.com/ciencia/2023-06-29/lo-que-se-debe-o-no-descubrir.html
@TIR_scienceblog +1. Academia is underpinned by unpaid labour. Of course it is the way in other occupations too. But the overwork won't go away while we comply! For example, professional services (i.e. admin) staff at Unis will say “No. We do not have headcount to do this extra thing” (and rightly so), then a new person is hired to cope with the increased workload. Academics on the hand just suck it up and do the extra thing at the weekend or whatever. So the academic overwork continues.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com